Elevated levels of interleukin‐33 are associated with allergic and eosinophilic asthma
IL‐33 is a recently discovered cytokine which plays an important role in asthma pathogenesis. Aim To evaluate serum IL‐33 in patients with asthma and healthy controls, and to evaluate the association of IL‐33 with different asthma phenotypes. Methods Patients with asthma (n = 115) and healthy subjec...
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| Veröffentlicht in: | Scandinavian journal of immunology 2019-05, Vol.89 (5), p.e12724-n/a |
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| container_title | Scandinavian journal of immunology |
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| creator | Gasiuniene, Edita Janulaityte, Ieva Zemeckiene, Zivile Barkauskiene, Diana Sitkauskiene, Brigita |
| description | IL‐33 is a recently discovered cytokine which plays an important role in asthma pathogenesis.
Aim
To evaluate serum IL‐33 in patients with asthma and healthy controls, and to evaluate the association of IL‐33 with different asthma phenotypes.
Methods
Patients with asthma (n = 115) and healthy subjects (n = 85) were included in the study. Subjects with asthma were divided into groups according to their phenotype: allergic/non‐allergic, eosinophilic/non‐eosinophilic, obese/non‐obese and severity according to GINA (mild, moderate and severe). The concentration of IL‐33 in serum was measured by standardized enzyme‐linked immunosorbent assay.
Results
The level of IL‐33 was significantly higher in patients with asthma when compared to healthy subjects (672.73 ± 104.47 pg/mL vs 268.52 ± 27.56 pg/mL, P |
| doi_str_mv | 10.1111/sji.12724 |
| format | Article |
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Aim
To evaluate serum IL‐33 in patients with asthma and healthy controls, and to evaluate the association of IL‐33 with different asthma phenotypes.
Methods
Patients with asthma (n = 115) and healthy subjects (n = 85) were included in the study. Subjects with asthma were divided into groups according to their phenotype: allergic/non‐allergic, eosinophilic/non‐eosinophilic, obese/non‐obese and severity according to GINA (mild, moderate and severe). The concentration of IL‐33 in serum was measured by standardized enzyme‐linked immunosorbent assay.
Results
The level of IL‐33 was significantly higher in patients with asthma when compared to healthy subjects (672.73 ± 104.47 pg/mL vs 268.52 ± 27.56 pg/mL, P < 0.05). IL‐33 was also higher in the allergic asthma group patients when compared to non‐allergic asthmatics (844.61 ± 152.08 pg/mL vs 369.56 ± 77.94 pg/mL, P < 0.05). There was a significantly higher serum IL‐33 level in the eosinophilic asthma group when compared to the group of non‐eosinophilic asthma patients (1001.10 ± 199.11 pg/mL vs 337.49 ± 72.68 pg/mL, P < 0.01). We did not find a significant difference in serum IL‐33 level between different asthma severity groups, obese and non‐obese asthmatics.
Conclusion
IL‐33 is increased in asthma patients, particularly in some phenotypes: allergic asthma and eosinophilic asthma.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/sji.12724</identifier><identifier>PMID: 30303258</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Asthma ; IL‐33 ; inflammation ; Leukocytes (eosinophilic) ; Phenotypes</subject><ispartof>Scandinavian journal of immunology, 2019-05, Vol.89 (5), p.e12724-n/a</ispartof><rights>2018 The Foundation for the Scandinavian Journal of Immunology</rights><rights>2018 The Foundation for the Scandinavian Journal of Immunology.</rights><rights>Copyright © 2019 The Foundation for the Scandinavian Journal of Immunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3884-e6c5947355c3c099b138f95130251f62e4a6d889d4e99de0b1fecaf4d1bdf9a03</citedby><cites>FETCH-LOGICAL-c3884-e6c5947355c3c099b138f95130251f62e4a6d889d4e99de0b1fecaf4d1bdf9a03</cites><orcidid>0000-0003-2295-2179</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsji.12724$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsji.12724$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30303258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gasiuniene, Edita</creatorcontrib><creatorcontrib>Janulaityte, Ieva</creatorcontrib><creatorcontrib>Zemeckiene, Zivile</creatorcontrib><creatorcontrib>Barkauskiene, Diana</creatorcontrib><creatorcontrib>Sitkauskiene, Brigita</creatorcontrib><title>Elevated levels of interleukin‐33 are associated with allergic and eosinophilic asthma</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>IL‐33 is a recently discovered cytokine which plays an important role in asthma pathogenesis.
Aim
To evaluate serum IL‐33 in patients with asthma and healthy controls, and to evaluate the association of IL‐33 with different asthma phenotypes.
Methods
Patients with asthma (n = 115) and healthy subjects (n = 85) were included in the study. Subjects with asthma were divided into groups according to their phenotype: allergic/non‐allergic, eosinophilic/non‐eosinophilic, obese/non‐obese and severity according to GINA (mild, moderate and severe). The concentration of IL‐33 in serum was measured by standardized enzyme‐linked immunosorbent assay.
Results
The level of IL‐33 was significantly higher in patients with asthma when compared to healthy subjects (672.73 ± 104.47 pg/mL vs 268.52 ± 27.56 pg/mL, P < 0.05). IL‐33 was also higher in the allergic asthma group patients when compared to non‐allergic asthmatics (844.61 ± 152.08 pg/mL vs 369.56 ± 77.94 pg/mL, P < 0.05). There was a significantly higher serum IL‐33 level in the eosinophilic asthma group when compared to the group of non‐eosinophilic asthma patients (1001.10 ± 199.11 pg/mL vs 337.49 ± 72.68 pg/mL, P < 0.01). We did not find a significant difference in serum IL‐33 level between different asthma severity groups, obese and non‐obese asthmatics.
Conclusion
IL‐33 is increased in asthma patients, particularly in some phenotypes: allergic asthma and eosinophilic asthma.</description><subject>Asthma</subject><subject>IL‐33</subject><subject>inflammation</subject><subject>Leukocytes (eosinophilic)</subject><subject>Phenotypes</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp10M9KxDAQBvAgiq6rB19ACl700DXJNG16lMW_CB5U8Bay6dTNmm3XpFW8-Qg-o09idNWDYC4DmR8fw0fIDqMjFt9hmNkR4wXPVsiAQS5SoBJWyYACpWmZFWKDbIYwo5QBL2CdbEDcABdyQO6OHT7pDqskTnQhaevENh16h_2Dbd5f3wAS7THRIbTGfsln200T7Rz6e2sS3VQJtsE27WJq3edH6KZzvUXWau0Cbn_PIbk9Ob4Zn6WXV6fn46PL1ICUWYq5EfFCEMKAoWU5YSDrUjCgXLA655jpvJKyrDIsywrphNVodJ1VbFLVpaYwJPvL3IVvH3sMnZrbYNA53WDbB8UZKySnRQ6R7v2hs7b3TbxOcc4oz0Qmi6gOlsr4NgSPtVp4O9f-RTGqPutWsW71VXe0u9-J_WSO1a_86TeCwyV4tg5f_k9S1xfny8gP08-Jpw</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Gasiuniene, Edita</creator><creator>Janulaityte, Ieva</creator><creator>Zemeckiene, Zivile</creator><creator>Barkauskiene, Diana</creator><creator>Sitkauskiene, Brigita</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2295-2179</orcidid></search><sort><creationdate>201905</creationdate><title>Elevated levels of interleukin‐33 are associated with allergic and eosinophilic asthma</title><author>Gasiuniene, Edita ; Janulaityte, Ieva ; Zemeckiene, Zivile ; Barkauskiene, Diana ; Sitkauskiene, Brigita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3884-e6c5947355c3c099b138f95130251f62e4a6d889d4e99de0b1fecaf4d1bdf9a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Asthma</topic><topic>IL‐33</topic><topic>inflammation</topic><topic>Leukocytes (eosinophilic)</topic><topic>Phenotypes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gasiuniene, Edita</creatorcontrib><creatorcontrib>Janulaityte, Ieva</creatorcontrib><creatorcontrib>Zemeckiene, Zivile</creatorcontrib><creatorcontrib>Barkauskiene, Diana</creatorcontrib><creatorcontrib>Sitkauskiene, Brigita</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gasiuniene, Edita</au><au>Janulaityte, Ieva</au><au>Zemeckiene, Zivile</au><au>Barkauskiene, Diana</au><au>Sitkauskiene, Brigita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated levels of interleukin‐33 are associated with allergic and eosinophilic asthma</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>2019-05</date><risdate>2019</risdate><volume>89</volume><issue>5</issue><spage>e12724</spage><epage>n/a</epage><pages>e12724-n/a</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>IL‐33 is a recently discovered cytokine which plays an important role in asthma pathogenesis.
Aim
To evaluate serum IL‐33 in patients with asthma and healthy controls, and to evaluate the association of IL‐33 with different asthma phenotypes.
Methods
Patients with asthma (n = 115) and healthy subjects (n = 85) were included in the study. Subjects with asthma were divided into groups according to their phenotype: allergic/non‐allergic, eosinophilic/non‐eosinophilic, obese/non‐obese and severity according to GINA (mild, moderate and severe). The concentration of IL‐33 in serum was measured by standardized enzyme‐linked immunosorbent assay.
Results
The level of IL‐33 was significantly higher in patients with asthma when compared to healthy subjects (672.73 ± 104.47 pg/mL vs 268.52 ± 27.56 pg/mL, P < 0.05). IL‐33 was also higher in the allergic asthma group patients when compared to non‐allergic asthmatics (844.61 ± 152.08 pg/mL vs 369.56 ± 77.94 pg/mL, P < 0.05). There was a significantly higher serum IL‐33 level in the eosinophilic asthma group when compared to the group of non‐eosinophilic asthma patients (1001.10 ± 199.11 pg/mL vs 337.49 ± 72.68 pg/mL, P < 0.01). We did not find a significant difference in serum IL‐33 level between different asthma severity groups, obese and non‐obese asthmatics.
Conclusion
IL‐33 is increased in asthma patients, particularly in some phenotypes: allergic asthma and eosinophilic asthma.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30303258</pmid><doi>10.1111/sji.12724</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2295-2179</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Asthma IL‐33 inflammation Leukocytes (eosinophilic) Phenotypes |
| title | Elevated levels of interleukin‐33 are associated with allergic and eosinophilic asthma |
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