Overexpression of cysteine‐glutamate transporter and CD44 for prediction of recurrence and survival in patients with oral cavity squamous cell carcinoma
Background This study analyzed the expression of CD44 and cystine‐glutamate transporter SLC7A11 (xCT) in primary oral cavity squamous cell carcinoma (SCC) and the relationships of expression to tumor recurrence and patient survival. Methods Associations between CD44 and xCT expression and clinicopat...
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| Veröffentlicht in: | Head & neck 2018-11, Vol.40 (11), p.2340-2346 |
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| creator | Lee, Jae Ryung Roh, Jong‐Lyel Lee, Sun Mi Park, Yangsoon Cho, Kyung‐Ja Choi, Seung‐Ho Nam, Soon Yuhl Kim, Sang Yoon |
| description | Background
This study analyzed the expression of CD44 and cystine‐glutamate transporter SLC7A11 (xCT) in primary oral cavity squamous cell carcinoma (SCC) and the relationships of expression to tumor recurrence and patient survival.
Methods
Associations between CD44 and xCT expression and clinicopathologic results were analyzed in 231 patients with oral cavity SCC. Cox proportional hazard analyses were used to identify factors associated with recurrence‐free survival (RFS), disease‐specific survival (DSS), and overall survival (OS).
Results
Overexpression of CD44 and/or xCT was associated with advanced T classification, perineural invasion, and lymphovascular invasion (P < .05 each). High expression of xCT was also associated with nodal metastasis and depth of invasion (P < .01 each). Multivariate analysis indicated that high expression of xCT and both xCT and CD44 were independent predictors of poor RFS, DSS, and OS (P < .05 each).
Conclusion
Overexpression of xCT or xCT plus CD44 may predict posttreatment recurrence and survival in patients with oral cavity SCC. |
| doi_str_mv | 10.1002/hed.25331 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2117820674</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2159983389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3531-182875d43eb8ecf416564ae27fced0803a586165c76cd07de96b1b21ff95450b3</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi1ERUvhwAsgS1zgkNaO7Tg5om2hSJV6ac-R40yoq8ROx862e-MROPN4PAne7vaCVM1hRr---fVLPyEfODvhjJWnt9CflEoI_ooccdboggmpX29vKQrBtDwkb2O8Y4yJSpZvyKFgeVTDjsifqzUgPM4IMbrgaRio3cQEzsPfX79_jksyk0lAExof54AJkBrf09WZlHQISPNn72za_yLYBRG8hScqLrh2azNS5-lskgOfIn1w6ZYGzKo1a5c2NN4vZgpLpBbGrYjW-TCZd-RgMGOE9_t9TG6-nV-vLorLq-8_Vl8vCyuU4AWvy1qrXgroarCD5JWqpIFSDxZ6VjNhVF1l0erK9kz30FQd70o-DI2SinXimHze-c4Y7heIqZ1c3EYxHnKqtuRc1yWrtMzop__Qu7Cgz-kypZqmFqJuMvVlR1kMMSIM7YxuMrhpOWu3hbW5sPapsMx-3Dsu3ZTVZ_K5oQyc7oAHN8LmZaf24vxsZ_kPU0OinQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2159983389</pqid></control><display><type>article</type><title>Overexpression of cysteine‐glutamate transporter and CD44 for prediction of recurrence and survival in patients with oral cavity squamous cell carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lee, Jae Ryung ; Roh, Jong‐Lyel ; Lee, Sun Mi ; Park, Yangsoon ; Cho, Kyung‐Ja ; Choi, Seung‐Ho ; Nam, Soon Yuhl ; Kim, Sang Yoon</creator><creatorcontrib>Lee, Jae Ryung ; Roh, Jong‐Lyel ; Lee, Sun Mi ; Park, Yangsoon ; Cho, Kyung‐Ja ; Choi, Seung‐Ho ; Nam, Soon Yuhl ; Kim, Sang Yoon</creatorcontrib><description>Background
This study analyzed the expression of CD44 and cystine‐glutamate transporter SLC7A11 (xCT) in primary oral cavity squamous cell carcinoma (SCC) and the relationships of expression to tumor recurrence and patient survival.
Methods
Associations between CD44 and xCT expression and clinicopathologic results were analyzed in 231 patients with oral cavity SCC. Cox proportional hazard analyses were used to identify factors associated with recurrence‐free survival (RFS), disease‐specific survival (DSS), and overall survival (OS).
Results
Overexpression of CD44 and/or xCT was associated with advanced T classification, perineural invasion, and lymphovascular invasion (P < .05 each). High expression of xCT was also associated with nodal metastasis and depth of invasion (P < .01 each). Multivariate analysis indicated that high expression of xCT and both xCT and CD44 were independent predictors of poor RFS, DSS, and OS (P < .05 each).
Conclusion
Overexpression of xCT or xCT plus CD44 may predict posttreatment recurrence and survival in patients with oral cavity SCC.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.25331</identifier><identifier>PMID: 30303590</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Amino Acid Transport System X-AG - genetics ; biomarker ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; CD44 ; CD44 antigen ; Cohort Studies ; cystine‐glutamate transporter (xCT) ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Glutamic acid transporter ; Head and neck ; Humans ; Hyaluronan Receptors - genetics ; Kaplan-Meier Estimate ; Male ; Metastases ; Middle Aged ; Mouth - pathology ; Mouth - surgery ; Mouth Neoplasms - genetics ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; Multivariate Analysis ; Neoplasm Invasiveness - pathology ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Oral cancer ; Oral cavity ; oral squamous cell carcinoma ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Risk Assessment ; Sex Factors ; Squamous cell carcinoma ; survival ; Survival Analysis</subject><ispartof>Head & neck, 2018-11, Vol.40 (11), p.2340-2346</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-182875d43eb8ecf416564ae27fced0803a586165c76cd07de96b1b21ff95450b3</citedby><cites>FETCH-LOGICAL-c3531-182875d43eb8ecf416564ae27fced0803a586165c76cd07de96b1b21ff95450b3</cites><orcidid>0000-0003-3636-954X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.25331$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.25331$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30303590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jae Ryung</creatorcontrib><creatorcontrib>Roh, Jong‐Lyel</creatorcontrib><creatorcontrib>Lee, Sun Mi</creatorcontrib><creatorcontrib>Park, Yangsoon</creatorcontrib><creatorcontrib>Cho, Kyung‐Ja</creatorcontrib><creatorcontrib>Choi, Seung‐Ho</creatorcontrib><creatorcontrib>Nam, Soon Yuhl</creatorcontrib><creatorcontrib>Kim, Sang Yoon</creatorcontrib><title>Overexpression of cysteine‐glutamate transporter and CD44 for prediction of recurrence and survival in patients with oral cavity squamous cell carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
This study analyzed the expression of CD44 and cystine‐glutamate transporter SLC7A11 (xCT) in primary oral cavity squamous cell carcinoma (SCC) and the relationships of expression to tumor recurrence and patient survival.
Methods
Associations between CD44 and xCT expression and clinicopathologic results were analyzed in 231 patients with oral cavity SCC. Cox proportional hazard analyses were used to identify factors associated with recurrence‐free survival (RFS), disease‐specific survival (DSS), and overall survival (OS).
Results
Overexpression of CD44 and/or xCT was associated with advanced T classification, perineural invasion, and lymphovascular invasion (P < .05 each). High expression of xCT was also associated with nodal metastasis and depth of invasion (P < .01 each). Multivariate analysis indicated that high expression of xCT and both xCT and CD44 were independent predictors of poor RFS, DSS, and OS (P < .05 each).
Conclusion
Overexpression of xCT or xCT plus CD44 may predict posttreatment recurrence and survival in patients with oral cavity SCC.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino Acid Transport System X-AG - genetics</subject><subject>biomarker</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>CD44</subject><subject>CD44 antigen</subject><subject>Cohort Studies</subject><subject>cystine‐glutamate transporter (xCT)</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Glutamic acid transporter</subject><subject>Head and neck</subject><subject>Humans</subject><subject>Hyaluronan Receptors - genetics</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Mouth - pathology</subject><subject>Mouth - surgery</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Oral cancer</subject><subject>Oral cavity</subject><subject>oral squamous cell carcinoma</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Sex Factors</subject><subject>Squamous cell carcinoma</subject><subject>survival</subject><subject>Survival Analysis</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi1ERUvhwAsgS1zgkNaO7Tg5om2hSJV6ac-R40yoq8ROx862e-MROPN4PAne7vaCVM1hRr---fVLPyEfODvhjJWnt9CflEoI_ooccdboggmpX29vKQrBtDwkb2O8Y4yJSpZvyKFgeVTDjsifqzUgPM4IMbrgaRio3cQEzsPfX79_jksyk0lAExof54AJkBrf09WZlHQISPNn72za_yLYBRG8hScqLrh2azNS5-lskgOfIn1w6ZYGzKo1a5c2NN4vZgpLpBbGrYjW-TCZd-RgMGOE9_t9TG6-nV-vLorLq-8_Vl8vCyuU4AWvy1qrXgroarCD5JWqpIFSDxZ6VjNhVF1l0erK9kz30FQd70o-DI2SinXimHze-c4Y7heIqZ1c3EYxHnKqtuRc1yWrtMzop__Qu7Cgz-kypZqmFqJuMvVlR1kMMSIM7YxuMrhpOWu3hbW5sPapsMx-3Dsu3ZTVZ_K5oQyc7oAHN8LmZaf24vxsZ_kPU0OinQ</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Lee, Jae Ryung</creator><creator>Roh, Jong‐Lyel</creator><creator>Lee, Sun Mi</creator><creator>Park, Yangsoon</creator><creator>Cho, Kyung‐Ja</creator><creator>Choi, Seung‐Ho</creator><creator>Nam, Soon Yuhl</creator><creator>Kim, Sang Yoon</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3636-954X</orcidid></search><sort><creationdate>201811</creationdate><title>Overexpression of cysteine‐glutamate transporter and CD44 for prediction of recurrence and survival in patients with oral cavity squamous cell carcinoma</title><author>Lee, Jae Ryung ; Roh, Jong‐Lyel ; Lee, Sun Mi ; Park, Yangsoon ; Cho, Kyung‐Ja ; Choi, Seung‐Ho ; Nam, Soon Yuhl ; Kim, Sang Yoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-182875d43eb8ecf416564ae27fced0803a586165c76cd07de96b1b21ff95450b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amino Acid Transport System X-AG - genetics</topic><topic>biomarker</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>CD44</topic><topic>CD44 antigen</topic><topic>Cohort Studies</topic><topic>cystine‐glutamate transporter (xCT)</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Glutamic acid transporter</topic><topic>Head and neck</topic><topic>Humans</topic><topic>Hyaluronan Receptors - genetics</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Mouth - pathology</topic><topic>Mouth - surgery</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - surgery</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Oral cancer</topic><topic>Oral cavity</topic><topic>oral squamous cell carcinoma</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Sex Factors</topic><topic>Squamous cell carcinoma</topic><topic>survival</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jae Ryung</creatorcontrib><creatorcontrib>Roh, Jong‐Lyel</creatorcontrib><creatorcontrib>Lee, Sun Mi</creatorcontrib><creatorcontrib>Park, Yangsoon</creatorcontrib><creatorcontrib>Cho, Kyung‐Ja</creatorcontrib><creatorcontrib>Choi, Seung‐Ho</creatorcontrib><creatorcontrib>Nam, Soon Yuhl</creatorcontrib><creatorcontrib>Kim, Sang Yoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jae Ryung</au><au>Roh, Jong‐Lyel</au><au>Lee, Sun Mi</au><au>Park, Yangsoon</au><au>Cho, Kyung‐Ja</au><au>Choi, Seung‐Ho</au><au>Nam, Soon Yuhl</au><au>Kim, Sang Yoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of cysteine‐glutamate transporter and CD44 for prediction of recurrence and survival in patients with oral cavity squamous cell carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2018-11</date><risdate>2018</risdate><volume>40</volume><issue>11</issue><spage>2340</spage><epage>2346</epage><pages>2340-2346</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
This study analyzed the expression of CD44 and cystine‐glutamate transporter SLC7A11 (xCT) in primary oral cavity squamous cell carcinoma (SCC) and the relationships of expression to tumor recurrence and patient survival.
Methods
Associations between CD44 and xCT expression and clinicopathologic results were analyzed in 231 patients with oral cavity SCC. Cox proportional hazard analyses were used to identify factors associated with recurrence‐free survival (RFS), disease‐specific survival (DSS), and overall survival (OS).
Results
Overexpression of CD44 and/or xCT was associated with advanced T classification, perineural invasion, and lymphovascular invasion (P < .05 each). High expression of xCT was also associated with nodal metastasis and depth of invasion (P < .01 each). Multivariate analysis indicated that high expression of xCT and both xCT and CD44 were independent predictors of poor RFS, DSS, and OS (P < .05 each).
Conclusion
Overexpression of xCT or xCT plus CD44 may predict posttreatment recurrence and survival in patients with oral cavity SCC.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30303590</pmid><doi>10.1002/hed.25331</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3636-954X</orcidid></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Amino Acid Transport System X-AG - genetics biomarker Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery CD44 CD44 antigen Cohort Studies cystine‐glutamate transporter (xCT) Disease-Free Survival Female Gene Expression Regulation, Neoplastic Glutamic acid transporter Head and neck Humans Hyaluronan Receptors - genetics Kaplan-Meier Estimate Male Metastases Middle Aged Mouth - pathology Mouth - surgery Mouth Neoplasms - genetics Mouth Neoplasms - mortality Mouth Neoplasms - pathology Mouth Neoplasms - surgery Multivariate Analysis Neoplasm Invasiveness - pathology Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Staging Oral cancer Oral cavity oral squamous cell carcinoma Predictive Value of Tests Prognosis Proportional Hazards Models Retrospective Studies Risk Assessment Sex Factors Squamous cell carcinoma survival Survival Analysis |
| title | Overexpression of cysteine‐glutamate transporter and CD44 for prediction of recurrence and survival in patients with oral cavity squamous cell carcinoma |
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