Effects of exendin‐4 on colonic motility in rats and its underlying mechanism

Background Glucagon‐like peptide‐1 (GLP‐1) receptor (GLP‐1R) agonists modulate gastrointestinal motility; however, the effects of GLP‐1R agonists on colonic motility are still controversial, and the molecular mechanism is unclear. Exendin‐4 shares 53% homology with GLP‐1 and is a full agonist of GLP...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurogastroenterology and motility 2019-02, Vol.31 (2), p.e13482-n/a
Hauptverfasser:	Yan, Lin, Tang, Qincai, Quan, Xiaojing, Ren, Haixia, Chen, Wei, Xia, Hong, Luo, Hesheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine Calcium channels Calcium channels (voltage-gated) Calcium conductance Colon Colon - drug effects colonic motility Exenatide - pharmacology exendin‐4 Gastric motility Gastrointestinal Motility - drug effects Glucagon Homology Incretins - pharmacology Male Motility Muscle Contraction - drug effects Muscle, Smooth - drug effects Nitric oxide Nitric-oxide synthase Organ Culture Techniques Potassium Potassium channels (calcium-gated) Potassium conductance Rats Rats, Wistar Smooth muscle Sodium channels Sodium channels (voltage-gated) Tetrodotoxin whole‐cell patch‐clamp
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!