Ranking in Vitro Dissolution of Inhaled Micronized Drug Powders including a Candidate Drug with Two Different Particle Sizes

Pulmonary dissolution of poorly soluble drug substances (DSs) may limit the drug absorption rate and consequently influence clinical performance. Dissolution rate is thus an important quality attribute, and its influence on in vivo drug release must be characterized, understood, and controlled early...

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Veröffentlicht in:	Molecular pharmaceutics 2018-11, Vol.15 (11), p.5319-5326
Hauptverfasser:	Franek, Frans, Fransson, Rebecca, Thörn, Helena, Bäckman, Per, Andersson, Patrik U, Tehler, Ulrika
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Chemistry, Pharmaceutical - instrumentation Chemistry, Pharmaceutical - methods Drug Compounding - methods Drug Compounding - standards Drug Liberation Particle Size Pharmaceutical Preparations - chemistry Powders Solubility
Online-Zugang:	Volltext
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