Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPARγ and PPARδ

The free fatty acid receptor 1 (FFA1) and peroxisome proliferator-activated receptors (PPARs) have attracted interest as potent targets for the treatment of metabolic syndrome such as type 2 diabetes. Based on the hypothesis that the dual agonists of PPARs and FFA1 would act as insulin sensitizers a...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-11, Vol.159, p.267-276
Hauptverfasser:	Li, Zheng, Zhou, Zongtao, Deng, Fengjian, Li, Yuyi, Zhang, Danjun, Zhang, Luyong
Format:	Artikel
Sprache:	eng
Schlagworte:	FFA1 Hybrid Pan agonist PPAR Type 2 diabetes
Online-Zugang:	Volltext
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