Prognostic Value of super(18)F-FDG PET/CT in Patients with Malignant Pleural Mesothelioma

Prognostic Value of super(18)F-FDG PET/CT in Patients with Malignant Pleural Mesothelioma

Purpose: To evaluate prognostic value of integrated 2-deoxy-2-[F-18]fluoro-d-glucose-positron emission tomography/computed tomography (FDG-PET/CT) and correlate histopathological subtype with maximum standardized uptake value (SUV sub(max)) and survival in patients with malignant mesothelioma (MM)....

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Veröffentlicht in:Molecular imaging and biology 2009-11, Vol.11 (6), p.473-479
Hauptverfasser: Lee, ST, Ghanem, M, Herbertson, R A, Berlangieri, SU, Byrne, A J, Tabone, K, Mitchell, P, Knight, SR, Feigen, M, Scott, A M
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container_end_page 479
container_issue 6
container_start_page 473
container_title Molecular imaging and biology
container_volume 11
creator Lee, ST
Ghanem, M
Herbertson, R A
Berlangieri, SU
Byrne, A J
Tabone, K
Mitchell, P
Knight, SR
Feigen, M
Scott, A M
description Purpose: To evaluate prognostic value of integrated 2-deoxy-2-[F-18]fluoro-d-glucose-positron emission tomography/computed tomography (FDG-PET/CT) and correlate histopathological subtype with maximum standardized uptake value (SUV sub(max)) and survival in patients with malignant mesothelioma (MM). Procedures: Retrospective review of FDG-PET/CT scans, with derivation of SUV sub(max) of FDG-avid lesions, was performed in patients with biopsy-proven MM. Clinical follow-up and Kaplan-Meier survival analysis was performed. Results: Forty-six patients (37 M:9 F; mean age 61years) with MM had a FDG-PET/CT scan in a 30-month period. Follow-up was available on 44/46 (96%) patients. Metastatic disease was detected in 9/46 (20%) patients on FDG-PET/CT, where 8/9 were previously undetected. Better survival was found in patients without metastases (p value
doi_str_mv 10.1007/s11307-009-0203-6
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Procedures: Retrospective review of FDG-PET/CT scans, with derivation of SUV sub(max) of FDG-avid lesions, was performed in patients with biopsy-proven MM. Clinical follow-up and Kaplan-Meier survival analysis was performed. Results: Forty-six patients (37 M:9 F; mean age 61years) with MM had a FDG-PET/CT scan in a 30-month period. Follow-up was available on 44/46 (96%) patients. Metastatic disease was detected in 9/46 (20%) patients on FDG-PET/CT, where 8/9 were previously undetected. Better survival was found in patients without metastases (p value&lt;0.05). Mean SUV sub(max) of primary pleural lesions in patients with metastatic disease was significantly higher than in patients without metastatic disease (p value&lt;0.05). Progression-free survival was significantly better in the epithelioid histology group compared to the biphasic group (p value 0.015). Conclusions: Detection of extrathoracic metastases on FDG-PET/CT and nonepithelioid histopathology are poor prognostic indicators in patients with MM.</description><identifier>ISSN: 1536-1632</identifier><identifier>EISSN: 1860-2002</identifier><identifier>DOI: 10.1007/s11307-009-0203-6</identifier><language>eng</language><ispartof>Molecular imaging and biology, 2009-11, Vol.11 (6), p.473-479</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Lee, ST</creatorcontrib><creatorcontrib>Ghanem, M</creatorcontrib><creatorcontrib>Herbertson, R A</creatorcontrib><creatorcontrib>Berlangieri, SU</creatorcontrib><creatorcontrib>Byrne, A J</creatorcontrib><creatorcontrib>Tabone, K</creatorcontrib><creatorcontrib>Mitchell, P</creatorcontrib><creatorcontrib>Knight, SR</creatorcontrib><creatorcontrib>Feigen, M</creatorcontrib><creatorcontrib>Scott, A M</creatorcontrib><title>Prognostic Value of super(18)F-FDG PET/CT in Patients with Malignant Pleural Mesothelioma</title><title>Molecular imaging and biology</title><description>Purpose: To evaluate prognostic value of integrated 2-deoxy-2-[F-18]fluoro-d-glucose-positron emission tomography/computed tomography (FDG-PET/CT) and correlate histopathological subtype with maximum standardized uptake value (SUV sub(max)) and survival in patients with malignant mesothelioma (MM). Procedures: Retrospective review of FDG-PET/CT scans, with derivation of SUV sub(max) of FDG-avid lesions, was performed in patients with biopsy-proven MM. Clinical follow-up and Kaplan-Meier survival analysis was performed. Results: Forty-six patients (37 M:9 F; mean age 61years) with MM had a FDG-PET/CT scan in a 30-month period. Follow-up was available on 44/46 (96%) patients. Metastatic disease was detected in 9/46 (20%) patients on FDG-PET/CT, where 8/9 were previously undetected. Better survival was found in patients without metastases (p value&lt;0.05). Mean SUV sub(max) of primary pleural lesions in patients with metastatic disease was significantly higher than in patients without metastatic disease (p value&lt;0.05). Progression-free survival was significantly better in the epithelioid histology group compared to the biphasic group (p value 0.015). 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Procedures: Retrospective review of FDG-PET/CT scans, with derivation of SUV sub(max) of FDG-avid lesions, was performed in patients with biopsy-proven MM. Clinical follow-up and Kaplan-Meier survival analysis was performed. Results: Forty-six patients (37 M:9 F; mean age 61years) with MM had a FDG-PET/CT scan in a 30-month period. Follow-up was available on 44/46 (96%) patients. Metastatic disease was detected in 9/46 (20%) patients on FDG-PET/CT, where 8/9 were previously undetected. Better survival was found in patients without metastases (p value&lt;0.05). Mean SUV sub(max) of primary pleural lesions in patients with metastatic disease was significantly higher than in patients without metastatic disease (p value&lt;0.05). Progression-free survival was significantly better in the epithelioid histology group compared to the biphasic group (p value 0.015). Conclusions: Detection of extrathoracic metastases on FDG-PET/CT and nonepithelioid histopathology are poor prognostic indicators in patients with MM.</abstract><doi>10.1007/s11307-009-0203-6</doi></addata></record>
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title Prognostic Value of super(18)F-FDG PET/CT in Patients with Malignant Pleural Mesothelioma
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