Orally Absorbed Derivatives of the β‑Lactamase Inhibitor Avibactam. Design of Novel Prodrugs of Sulfate Containing Drugs

Only one FDA-approved β-lactamase inhibitor has ever been orally available: clavulanic acid, approved in 1984. Avibactam, approved by FDA in 2015, is the first of a new class of BLIs called diazabicyclooctanes, or “DBOs”. This class has much broader coverage than clavulanic acid but can only be admi...

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Veröffentlicht in:	Journal of medicinal chemistry 2018-11, Vol.61 (22), p.10340-10344
Hauptverfasser:	Gordon, Eric M, Duncton, Matthew A. J, Gallop, Mark A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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