Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer

: PARP proteins represent a class of post-translational modification enzymes with diverse cellular functions. Targeting PARPs has proven to be efficacious clinically, but exploration of the therapeutic potential of PARP inhibition has been limited to targeting poly(ADP-ribose) generating PARP, inclu...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-12, Vol.78 (23), p.6691-6702
Hauptverfasser:	Wang, Zebin, Grosskurth, Shaun E, Cheung, Tony, Petteruti, Philip, Zhang, Jingwen, Wang, Xin, Wang, Wenxian, Gharahdaghi, Farzin, Wu, Jiaquan, Su, Nancy, Howard, Ryan T, Mayo, Michele, Widzowski, Dan, Scott, David A, Johannes, Jeffrey W, Lamb, Michelle L, Lawson, Deborah, Dry, Jonathan R, Lyne, Paul D, Tate, Edward W, Zinda, Michael, Mikule, Keith, Fawell, Stephen E, Reimer, Corinne, Chen, Huawei
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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