Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA

Gold nanorods are one of the most widely explored inorganic materials in nanomedicine for diagnostics, therapeutics and sensing 1 . It has been shown that gold nanorods are not cytotoxic and localize within cytoplasmic vesicles following endocytosis, with no nuclear localization 2 , 3 , but other st...

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Veröffentlicht in:	Nature nanotechnology 2018-12, Vol.13 (12), p.1148-1153
Hauptverfasser:	Ho, Diwei, Kretzmann, Jessica A., Norret, Marck, Toshniwal, Priyanka, Veder, Jean-Pierre, Jiang, Haibo, Guagliardo, Paul, Munshi, Alaa M., Chawla, Reena, Evans, Cameron W., Clemons, Tristan D., Nguyen, Michelle, Kretzmann, Amy L., Blythe, Amanda J., Saunders, Martin, Archer, Michael, Fitzgerald, Melinda, Keelan, Jeffrey A., Bond, Charles S., Kilburn, Matt R., Hurley, Laurence H., Smith, Nicole M., Iyer, K. Swaminathan
Format:	Artikel
Sprache:	eng
Schlagworte:	140/146 639/925/350 639/925/352 639/925/928 Chemical speciation Chemistry and Materials Science Conjugation Cytotoxicity Deoxyribonucleic acid DNA Endocytosis Gene expression Gene mapping Gold Inorganic materials Intracellular Letter Localization Mapping Materials Science Nanorods Nanotechnology Nanotechnology and Microengineering Nuclei (cytology) Organic chemistry Speciation
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