Kisspeptin in the early post–partum of the dairy cow
Contents Recently, a new molecule, kisspeptin (Kp), and in particular Kisspeptin 10 (Kp10), was implicated in stimulating the hypothalamic–pituitary–gonadal axis. The aim of this study was to evaluate circulating Kp10 levels in the early post–partum period of the dairy cow. Blood samples were collec...
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| Veröffentlicht in: | Reproduction in domestic animals 2019-02, Vol.54 (2), p.195-198 |
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| container_title | Reproduction in domestic animals |
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| creator | Rizzo, Annalisa Ceci, Edmondo Guaricci, Antonio Ciro Sciorsci, Raffaele Luigi |
| description | Contents
Recently, a new molecule, kisspeptin (Kp), and in particular Kisspeptin 10 (Kp10), was implicated in stimulating the hypothalamic–pituitary–gonadal axis. The aim of this study was to evaluate circulating Kp10 levels in the early post–partum period of the dairy cow. Blood samples were collected from 40 dairy cows, at 10 (T10), 12 (T12), 14 (T14) and 16 (T16) days after calving. Progesterone (P4) levels were evaluated using ELISA, and levels of oestrogens (E2) and Kp were evaluated using a radio‐immunologic method. After an initial plateau, Kp10 significantly increased at T14 and decreased at T16. The P4 and E2 mean serum values remained in the physiological range. It is likely that Kp10 enhanced hypothalamic GnRH release as well as pituitary gonadotropin secretion, thus promoting follicular growth and the increase in E2 levels, which might have further enhanced Kp10 release through a positive feedback loop. To our best knowledge, this is the first report on the range of Kp10 blood concentration during the early post–partum period in the dairy cow. The results of our study will increase our current understanding of the complex neuro‐endocrine crosstalk underlying the resumption of ovarian cyclicity in the dairy cow. |
| doi_str_mv | 10.1111/rda.13325 |
| format | Article |
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Recently, a new molecule, kisspeptin (Kp), and in particular Kisspeptin 10 (Kp10), was implicated in stimulating the hypothalamic–pituitary–gonadal axis. The aim of this study was to evaluate circulating Kp10 levels in the early post–partum period of the dairy cow. Blood samples were collected from 40 dairy cows, at 10 (T10), 12 (T12), 14 (T14) and 16 (T16) days after calving. Progesterone (P4) levels were evaluated using ELISA, and levels of oestrogens (E2) and Kp were evaluated using a radio‐immunologic method. After an initial plateau, Kp10 significantly increased at T14 and decreased at T16. The P4 and E2 mean serum values remained in the physiological range. It is likely that Kp10 enhanced hypothalamic GnRH release as well as pituitary gonadotropin secretion, thus promoting follicular growth and the increase in E2 levels, which might have further enhanced Kp10 release through a positive feedback loop. To our best knowledge, this is the first report on the range of Kp10 blood concentration during the early post–partum period in the dairy cow. The results of our study will increase our current understanding of the complex neuro‐endocrine crosstalk underlying the resumption of ovarian cyclicity in the dairy cow.</description><identifier>ISSN: 0936-6768</identifier><identifier>EISSN: 1439-0531</identifier><identifier>DOI: 10.1111/rda.13325</identifier><identifier>PMID: 30168873</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animals ; Blood ; Blood levels ; Bovine spongiform encephalopathy ; Cattle ; Cattle - physiology ; Crosstalk ; dairy cow ; Enzyme-linked immunosorbent assay ; Estrogens ; Estrogens - blood ; Estrogens - physiology ; Feedback loops ; Female ; Follicle Stimulating Hormone - blood ; Gonadotropin-releasing hormone ; Gonadotropin-Releasing Hormone - metabolism ; Gonadotropins ; Hypothalamus ; Kiss1 protein ; kisspeptin 10 ; Kisspeptins - blood ; Kisspeptins - physiology ; Luteinizing Hormone - blood ; oestrogen ; Ovulation - physiology ; Pituitary ; Pituitary (anterior) ; Pituitary Gland - metabolism ; Positive feedback ; Postpartum Period - physiology ; post–partum ; Progesterone ; Progesterone - blood ; Progesterone - physiology</subject><ispartof>Reproduction in domestic animals, 2019-02, Vol.54 (2), p.195-198</ispartof><rights>2018 Blackwell Verlag GmbH</rights><rights>2018 Blackwell Verlag GmbH.</rights><rights>Copyright © 2019 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-e1ff7f73daf0c21e705b5021ae0ebb24f49231c5326822df1b07d1e89b4be603</citedby><cites>FETCH-LOGICAL-c3535-e1ff7f73daf0c21e705b5021ae0ebb24f49231c5326822df1b07d1e89b4be603</cites><orcidid>0000-0002-1141-3084</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Frda.13325$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Frda.13325$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30168873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rizzo, Annalisa</creatorcontrib><creatorcontrib>Ceci, Edmondo</creatorcontrib><creatorcontrib>Guaricci, Antonio Ciro</creatorcontrib><creatorcontrib>Sciorsci, Raffaele Luigi</creatorcontrib><title>Kisspeptin in the early post–partum of the dairy cow</title><title>Reproduction in domestic animals</title><addtitle>Reprod Domest Anim</addtitle><description>Contents
Recently, a new molecule, kisspeptin (Kp), and in particular Kisspeptin 10 (Kp10), was implicated in stimulating the hypothalamic–pituitary–gonadal axis. The aim of this study was to evaluate circulating Kp10 levels in the early post–partum period of the dairy cow. Blood samples were collected from 40 dairy cows, at 10 (T10), 12 (T12), 14 (T14) and 16 (T16) days after calving. Progesterone (P4) levels were evaluated using ELISA, and levels of oestrogens (E2) and Kp were evaluated using a radio‐immunologic method. After an initial plateau, Kp10 significantly increased at T14 and decreased at T16. The P4 and E2 mean serum values remained in the physiological range. It is likely that Kp10 enhanced hypothalamic GnRH release as well as pituitary gonadotropin secretion, thus promoting follicular growth and the increase in E2 levels, which might have further enhanced Kp10 release through a positive feedback loop. To our best knowledge, this is the first report on the range of Kp10 blood concentration during the early post–partum period in the dairy cow. The results of our study will increase our current understanding of the complex neuro‐endocrine crosstalk underlying the resumption of ovarian cyclicity in the dairy cow.</description><subject>Animals</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Bovine spongiform encephalopathy</subject><subject>Cattle</subject><subject>Cattle - physiology</subject><subject>Crosstalk</subject><subject>dairy cow</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Estrogens</subject><subject>Estrogens - blood</subject><subject>Estrogens - physiology</subject><subject>Feedback loops</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropin-releasing hormone</subject><subject>Gonadotropin-Releasing Hormone - metabolism</subject><subject>Gonadotropins</subject><subject>Hypothalamus</subject><subject>Kiss1 protein</subject><subject>kisspeptin 10</subject><subject>Kisspeptins - blood</subject><subject>Kisspeptins - physiology</subject><subject>Luteinizing Hormone - blood</subject><subject>oestrogen</subject><subject>Ovulation - physiology</subject><subject>Pituitary</subject><subject>Pituitary (anterior)</subject><subject>Pituitary Gland - metabolism</subject><subject>Positive feedback</subject><subject>Postpartum Period - physiology</subject><subject>post–partum</subject><subject>Progesterone</subject><subject>Progesterone - blood</subject><subject>Progesterone - physiology</subject><issn>0936-6768</issn><issn>1439-0531</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1Kw0AQgBdRbK0efAEJeNFD2p2dbDY5lvqLBUF6D5tkF1OSJu4mlNx8B9_QJ3FtqgfBZWAP8_ExfIScA52CezOTyykgMn5AxhBg7FOOcEjGNMbQD0UYjciJtWtKgUdCHJMRUgijSOCYhE-FtY1q2mLjuWlflaekKXuvqW37-f7RSNN2lVfr3SqXhem9rN6ekiMtS6vO9v-ErO5uV4sHf_l8_7iYL_0MOXJfgdZCC8ylphkDJShPOWUgFVVpygIdxAwh48jCiLFcQ0pFDiqK0yBVIcUJuRq0janfOmXbpCpspspSblTd2YQBCOAYcHTo5R90XXdm445zlIhcJnRVJuR6oDJTW2uUThpTVNL0CdDku2XiWia7lo692Bu7tFL5L_kTzwGzAdgWper_NyUvN_NB-QWMdXxO</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Rizzo, Annalisa</creator><creator>Ceci, Edmondo</creator><creator>Guaricci, Antonio Ciro</creator><creator>Sciorsci, Raffaele Luigi</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1141-3084</orcidid></search><sort><creationdate>201902</creationdate><title>Kisspeptin in the early post–partum of the dairy cow</title><author>Rizzo, Annalisa ; Ceci, Edmondo ; Guaricci, Antonio Ciro ; Sciorsci, Raffaele Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-e1ff7f73daf0c21e705b5021ae0ebb24f49231c5326822df1b07d1e89b4be603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Bovine spongiform encephalopathy</topic><topic>Cattle</topic><topic>Cattle - physiology</topic><topic>Crosstalk</topic><topic>dairy cow</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Estrogens</topic><topic>Estrogens - blood</topic><topic>Estrogens - physiology</topic><topic>Feedback loops</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropin-releasing hormone</topic><topic>Gonadotropin-Releasing Hormone - metabolism</topic><topic>Gonadotropins</topic><topic>Hypothalamus</topic><topic>Kiss1 protein</topic><topic>kisspeptin 10</topic><topic>Kisspeptins - blood</topic><topic>Kisspeptins - physiology</topic><topic>Luteinizing Hormone - blood</topic><topic>oestrogen</topic><topic>Ovulation - physiology</topic><topic>Pituitary</topic><topic>Pituitary (anterior)</topic><topic>Pituitary Gland - metabolism</topic><topic>Positive feedback</topic><topic>Postpartum Period - physiology</topic><topic>post–partum</topic><topic>Progesterone</topic><topic>Progesterone - blood</topic><topic>Progesterone - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rizzo, Annalisa</creatorcontrib><creatorcontrib>Ceci, Edmondo</creatorcontrib><creatorcontrib>Guaricci, Antonio Ciro</creatorcontrib><creatorcontrib>Sciorsci, Raffaele Luigi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction in domestic animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizzo, Annalisa</au><au>Ceci, Edmondo</au><au>Guaricci, Antonio Ciro</au><au>Sciorsci, Raffaele Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kisspeptin in the early post–partum of the dairy cow</atitle><jtitle>Reproduction in domestic animals</jtitle><addtitle>Reprod Domest Anim</addtitle><date>2019-02</date><risdate>2019</risdate><volume>54</volume><issue>2</issue><spage>195</spage><epage>198</epage><pages>195-198</pages><issn>0936-6768</issn><eissn>1439-0531</eissn><abstract>Contents
Recently, a new molecule, kisspeptin (Kp), and in particular Kisspeptin 10 (Kp10), was implicated in stimulating the hypothalamic–pituitary–gonadal axis. The aim of this study was to evaluate circulating Kp10 levels in the early post–partum period of the dairy cow. Blood samples were collected from 40 dairy cows, at 10 (T10), 12 (T12), 14 (T14) and 16 (T16) days after calving. Progesterone (P4) levels were evaluated using ELISA, and levels of oestrogens (E2) and Kp were evaluated using a radio‐immunologic method. After an initial plateau, Kp10 significantly increased at T14 and decreased at T16. The P4 and E2 mean serum values remained in the physiological range. It is likely that Kp10 enhanced hypothalamic GnRH release as well as pituitary gonadotropin secretion, thus promoting follicular growth and the increase in E2 levels, which might have further enhanced Kp10 release through a positive feedback loop. To our best knowledge, this is the first report on the range of Kp10 blood concentration during the early post–partum period in the dairy cow. The results of our study will increase our current understanding of the complex neuro‐endocrine crosstalk underlying the resumption of ovarian cyclicity in the dairy cow.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>30168873</pmid><doi>10.1111/rda.13325</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-1141-3084</orcidid></addata></record> |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Animals Blood Blood levels Bovine spongiform encephalopathy Cattle Cattle - physiology Crosstalk dairy cow Enzyme-linked immunosorbent assay Estrogens Estrogens - blood Estrogens - physiology Feedback loops Female Follicle Stimulating Hormone - blood Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - metabolism Gonadotropins Hypothalamus Kiss1 protein kisspeptin 10 Kisspeptins - blood Kisspeptins - physiology Luteinizing Hormone - blood oestrogen Ovulation - physiology Pituitary Pituitary (anterior) Pituitary Gland - metabolism Positive feedback Postpartum Period - physiology post–partum Progesterone Progesterone - blood Progesterone - physiology |
| title | Kisspeptin in the early post–partum of the dairy cow |
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