Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception

Generalised tonic-clonic seizures, generated by abnormal neuronal hyper-activity, cause a significant and long-lasting increase in the nociceptive threshold. The pedunculopontine tegmental nucleus (PPTN) plays a crucial role in the regulation of seizures as well as the modulation of pain, but its ro...

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Veröffentlicht in:	Physiology & behavior 2018-10, Vol.194, p.162-169
Hauptverfasser:	de Oliveira, Rithiele Cristina, de Oliveira, Ricardo, Falconi-Sobrinho, Luiz Luciano, Biagioni, Audrey Franceschi, Almada, Rafael Carvalho, dos Anjos-Garcia, Tayllon, Bazaglia-de-Sousa, Guilherme, Khan, Asmat Ullah, Coimbra, Norberto Cysne
Format:	Artikel
Sprache:	eng
Schlagworte:	Epilepsy Ibotenic acid laboratory animals neurons neurotoxicity Pain Pedunculopontine tegmental nucleus Pentylenetetrazole Postictal antinociception rats seizures Tonic-clonic seizures
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