Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site

Antibiotic-resistant strains of Staphylococcus aureus pose a major threat to human health and there is an ongoing need for new antibiotics to treat resistant infections. In a high throughput screen (HTS) of 230 000 small molecules designed to identify bioactive wall teichoic acid (WTA) inhibitors, w...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-08, Vol.139 (31), p.10597-10600
Hauptverfasser:	Matano, Leigh M, Morris, Heidi G, Hesser, Anthony R, Martin, Sara E. S, Lee, Wonsik, Owens, Tristan W, Laney, Emaline, Nakaminami, Hidemasa, Hooper, David, Meredith, Timothy C, Walker, Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Adenosine Triphosphatases - antagonists & inhibitors adenosine triphosphate adenosinetriphosphatase antibiotic resistance antibiotics ATP-Binding Cassette Transporters - metabolism Binding Sites Cell Wall - chemistry Cell Wall - drug effects Cell Wall - metabolism Drug Delivery Systems Drug Evaluation, Preclinical Enzyme Activation - drug effects enzyme activity enzyme inhibition hydrolysis Methicillin-Resistant Staphylococcus aureus - drug effects Models, Biological Molecular Structure Peptidoglycan - chemistry Peptidoglycan - metabolism peptidoglycans Protein Binding - drug effects Staphylococcus aureus Staphylococcus aureus - drug effects synthesis teichoic acids Teichoic Acids - pharmacology therapeutics
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