Molecular docking, and anti-biofilm activity of gold-complexed sulfonamides on Pseudomonas aeruginosa
The antibacterial activity of sulfadiazine Au-PPh3, sulfadiazine Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3, sulfamethoxazole Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3 were tested against Pseudomonas aeruginosa. The antibacterial activity of sulfonamide was tested against P. aeruginosa through the MI...
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| Veröffentlicht in: | Microbial pathogenesis 2018-12, Vol.125, p.393-400 |
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| creator | Mizdal, Caren Rigon Stefanello, Sílvio Terra Nogara, Pablo Andrei Antunes Soares, Félix Alexandre de Lourenço Marques, Lenice de Campos, Marli Matiko Anraku |
| description | The antibacterial activity of sulfadiazine Au-PPh3, sulfadiazine Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3, sulfamethoxazole Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3 were tested against Pseudomonas aeruginosa. The antibacterial activity of sulfonamide was tested against P. aeruginosa through the MIC assay, quantitative analysis of biofilm inhibition and observation of biofilm formation with fluorescence microscopy. Besides, the compounds presented remarkable inhibition of P. aeruginosa biofilm formation. Furthermore, molecular docking was performed to identify the key structural features of these compounds with the binding site of the LasR receptor.
•Gold-complexed sulfonamides have antibacterial activity against P. aeruginosa.•Gold-complexed sulfonamides have shown antibiofilm activity.•Sulfonamides reduce the bacteria virulence and spread.•Gold-complexed sulfonamides interacted with LasR active site. |
| doi_str_mv | 10.1016/j.micpath.2018.10.004 |
| format | Article |
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•Gold-complexed sulfonamides have antibacterial activity against P. aeruginosa.•Gold-complexed sulfonamides have shown antibiofilm activity.•Sulfonamides reduce the bacteria virulence and spread.•Gold-complexed sulfonamides interacted with LasR active site.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2018.10.004</identifier><identifier>PMID: 30290269</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Bacterial Proteins - chemistry ; Bacterial Proteins - metabolism ; Biofilm ; Biofilms - drug effects ; Gold - chemistry ; Gold - pharmacology ; Gold-complexed sulfonamides ; LasR ; Microbial Sensitivity Tests ; Microscopy, Fluorescence ; Molecular Docking Simulation ; PA01 ; Protein Binding ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - physiology ; Sulfonamides - chemistry ; Sulfonamides - pharmacology ; Trans-Activators - chemistry ; Trans-Activators - metabolism</subject><ispartof>Microbial pathogenesis, 2018-12, Vol.125, p.393-400</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-a0e42372fed4aa4c25e6f047dad01d1668978aa08948d3c88b35039301e92d013</citedby><cites>FETCH-LOGICAL-c365t-a0e42372fed4aa4c25e6f047dad01d1668978aa08948d3c88b35039301e92d013</cites><orcidid>0000-0002-6453-7902 ; 0000-0002-6673-6550 ; 0000-0002-9133-6102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micpath.2018.10.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30290269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizdal, Caren Rigon</creatorcontrib><creatorcontrib>Stefanello, Sílvio Terra</creatorcontrib><creatorcontrib>Nogara, Pablo Andrei</creatorcontrib><creatorcontrib>Antunes Soares, Félix Alexandre</creatorcontrib><creatorcontrib>de Lourenço Marques, Lenice</creatorcontrib><creatorcontrib>de Campos, Marli Matiko Anraku</creatorcontrib><title>Molecular docking, and anti-biofilm activity of gold-complexed sulfonamides on Pseudomonas aeruginosa</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>The antibacterial activity of sulfadiazine Au-PPh3, sulfadiazine Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3, sulfamethoxazole Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3 were tested against Pseudomonas aeruginosa. The antibacterial activity of sulfonamide was tested against P. aeruginosa through the MIC assay, quantitative analysis of biofilm inhibition and observation of biofilm formation with fluorescence microscopy. Besides, the compounds presented remarkable inhibition of P. aeruginosa biofilm formation. Furthermore, molecular docking was performed to identify the key structural features of these compounds with the binding site of the LasR receptor.
•Gold-complexed sulfonamides have antibacterial activity against P. aeruginosa.•Gold-complexed sulfonamides have shown antibiofilm activity.•Sulfonamides reduce the bacteria virulence and spread.•Gold-complexed sulfonamides interacted with LasR active site.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Proteins - chemistry</subject><subject>Bacterial Proteins - metabolism</subject><subject>Biofilm</subject><subject>Biofilms - drug effects</subject><subject>Gold - chemistry</subject><subject>Gold - pharmacology</subject><subject>Gold-complexed sulfonamides</subject><subject>LasR</subject><subject>Microbial Sensitivity Tests</subject><subject>Microscopy, Fluorescence</subject><subject>Molecular Docking Simulation</subject><subject>PA01</subject><subject>Protein Binding</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas aeruginosa - physiology</subject><subject>Sulfonamides - chemistry</subject><subject>Sulfonamides - pharmacology</subject><subject>Trans-Activators - chemistry</subject><subject>Trans-Activators - metabolism</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v2zAMhoViQ5Nl-wktdNxhzijJdqRTUQT7AjK0h_YsKBKdKpWtVLKD5t_XQdJddyAIvHhIgg8hVwzmDFj9fTtvvd2Z_mnOgckxmwOUF2TKQNUF4yA_kClIyYsSGEzIp5y3AKBKoS7JRABXwGs1Jfg3BrRDMIm6aJ99t_lGTefG6n2x9rHxoaXG9n7v-wONDd3E4Aob213AV3Q0D6GJnWm9w0xjR-8zDi62Y5SpwTRsfBez-Uw-NiZk_HLuM_L488fD8nexuvv1Z3m7Kqyoq74wgCUXC96gK40pLa-wbqBcOOOAOVbXUi2kMSBVKZ2wUq5FBUIJYKj4iIgZ-Xrau0vxZcDc69ZniyGYDuOQNWeslhVj8ohWJ9SmmHPCRu-Sb006aAb6aFhv9dmwPho-xqPhce76fGJYt-j-Tb0rHYGbE4Djo3uPSWfrsbPofELbaxf9f068AZONkCM</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Mizdal, Caren Rigon</creator><creator>Stefanello, Sílvio Terra</creator><creator>Nogara, Pablo Andrei</creator><creator>Antunes Soares, Félix Alexandre</creator><creator>de Lourenço Marques, Lenice</creator><creator>de Campos, Marli Matiko Anraku</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6453-7902</orcidid><orcidid>https://orcid.org/0000-0002-6673-6550</orcidid><orcidid>https://orcid.org/0000-0002-9133-6102</orcidid></search><sort><creationdate>201812</creationdate><title>Molecular docking, and anti-biofilm activity of gold-complexed sulfonamides on Pseudomonas aeruginosa</title><author>Mizdal, Caren Rigon ; 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The antibacterial activity of sulfonamide was tested against P. aeruginosa through the MIC assay, quantitative analysis of biofilm inhibition and observation of biofilm formation with fluorescence microscopy. Besides, the compounds presented remarkable inhibition of P. aeruginosa biofilm formation. Furthermore, molecular docking was performed to identify the key structural features of these compounds with the binding site of the LasR receptor.
•Gold-complexed sulfonamides have antibacterial activity against P. aeruginosa.•Gold-complexed sulfonamides have shown antibiofilm activity.•Sulfonamides reduce the bacteria virulence and spread.•Gold-complexed sulfonamides interacted with LasR active site.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30290269</pmid><doi>10.1016/j.micpath.2018.10.004</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6453-7902</orcidid><orcidid>https://orcid.org/0000-0002-6673-6550</orcidid><orcidid>https://orcid.org/0000-0002-9133-6102</orcidid></addata></record> |
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| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biofilm Biofilms - drug effects Gold - chemistry Gold - pharmacology Gold-complexed sulfonamides LasR Microbial Sensitivity Tests Microscopy, Fluorescence Molecular Docking Simulation PA01 Protein Binding Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - physiology Sulfonamides - chemistry Sulfonamides - pharmacology Trans-Activators - chemistry Trans-Activators - metabolism |
| title | Molecular docking, and anti-biofilm activity of gold-complexed sulfonamides on Pseudomonas aeruginosa |
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