Endoplasmic Reticulum Stress-Induced NLRP1 Inflammasome Activation Contributes to Myocardial Ischemia/Reperfusion Injury

ABSTRACTStudies have shown that Nod-like receptor protein (NLRP) 3 inflammasome activation contributes to myocardial ischemia/reperfusion (I/R) injury. However, the role and mechanism of NLRP1 inflammasome in myocardial I/R injury remain unknown. Endoplasmic reticulum (ER) stress is involved in the...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2019-04, Vol.51 (4), p.511-518
Hauptverfasser:	Cao, Lei, Chen, Yuguo, Zhang, Zhe, Li, Yong, Zhao, Peiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis - physiology Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Blotting, Western Cells, Cultured Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - genetics Inflammasomes - drug effects Inflammasomes - immunology Inflammasomes - metabolism Male Mice Mice, Inbred C57BL Myocardial Reperfusion Injury - immunology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology NF-kappa B - metabolism Pyrrolidines - pharmacology Real-Time Polymerase Chain Reaction Signal Transduction - physiology Thiocarbamates - pharmacology
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