Insertion sequences in the CRISPR-Cas system regulate horizontal antimicrobial resistance gene transfer in Shigella strains

•Insert sequence (IS) elements were identified in the CRISPR-Cas system in Shigella.•IS600 decreased expression of the cse2 gene.•Bacteria regulate CRISPR-Cas system activity by ISs to acquire beneficial genes through horizontal gene transfer (HGT).•Mechanism underlying CRISPR-Cas-mediated HGT of an...

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Veröffentlicht in:	International journal of antimicrobial agents 2019-02, Vol.53 (2), p.109-115
Hauptverfasser:	Chen, Shuaiyin, Liu, Huiying, Liang, Wenjuan, Hong, Lijuan, Zhang, Bing, Huang, Lu, Guo, Xiangjiao, Duan, Guangcai
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antimicrobial resistance Chloramphenicol - pharmacology Chloramphenicol Resistance - genetics CRISPR-Cas CRISPR-Cas Systems - genetics DNA Transposable Elements - genetics DNA, Intergenic - genetics Drug Resistance, Multiple, Bacterial - genetics Gene Transfer, Horizontal - genetics Horizontal gene transfer Humans Insertion sequence IS600 Microbial Sensitivity Tests Shigella Shigella - drug effects Shigella - genetics Shigella - isolation & purification
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