Effect of poly (l-lactic acid) scaffolds seeded with aligned diaphragmatic myoblasts overexpressing connexin-43 on infarct size and ventricular function in sheep with acute coronary occlusion

Diaphragmatic myoblasts (DM) are stem cells of the diaphragm, a muscle displaying high resistance to stress and exhaustion. We hypothesized that DM modified to overexpress connexin-43 (cx43), seeded on aligned poly (l-lactic acid) (PLLA) sheets would decrease infarct size and improve ventricular fun...

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Veröffentlicht in:	Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2018-01, Vol.46 (S3), p.717-724
Hauptverfasser:	Giménez, Carlos Sebastián, Olea, Fernanda Daniela, Locatelli, Paola, Dewey, Ricardo A., Abraham, Gustavo Abel, Montini Ballarin, Florencia, Bauzá, Maria del Rosario, Hnatiuk, Anna, De Lorenzi, Andrea, Neira Sepúlveda, Ángela, Embon, Mario, Cuniberti, Luis, Crottogini, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myocardial infarction Animals Connexin 43 Connexin 43 - biosynthesis Coronary Occlusion - metabolism Coronary Occlusion - pathology Coronary Occlusion - physiopathology Coronary Occlusion - therapy Diaphragm Diaphragm - metabolism Diaphragm - pathology diaphragmatic myoblasts Echocardiography Electrocardiography Exhaustion High resistance Lactic acid Magnetic resonance Male Muscles Myoblasts Myoblasts - metabolism Myoblasts - pathology Myoblasts - transplantation Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - therapy Occlusion Ovis aries poly (l-lactic acid) Polyesters - chemistry Polylactic acid regenerative medicine scaffolds Sheep Sheets Stem cells Tissue Scaffolds - chemistry Ventricle Ventricular Function
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