Biphasic-Scanning Ion Conductance Microscopy

A concentration gradient driven imaging mechanism is described for scanning ion conductance microscopy (SICM). Two different solution phases, one filling a double-barrel pipet and one in the bath, are used to afford probe control and imaging under nonstandard SICM conditions. Under these conditions,...

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Veröffentlicht in:Analytical chemistry (Washington) 2018-10, Vol.90 (20), p.11797-11801
Hauptverfasser: Choi, Myunghoon, Baker, Lane A
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description A concentration gradient driven imaging mechanism is described for scanning ion conductance microscopy (SICM). Two different solution phases, one filling a double-barrel pipet and one in the bath, are used to afford probe control and imaging under nonstandard SICM conditions. Under these conditions, solutions with no added electrolyte can be utilized as the bath solution. Further, both positive and negative feedback modes are exhibited as the probe approaches the surface. We term this method biphasic-SICM (BP-SICM). Technical details of implementing BP-SICM and operational principles are described herein.
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subjects Analytical chemistry
Chemistry
Concentration gradient
Conductance
Electrolytes
Microscopy
Negative feedback
Scanning
title Biphasic-Scanning Ion Conductance Microscopy
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