Structural basis of the nucleosome transition during RNA polymerase II passage

Genomic DNA forms chromatin, in which the nucleosome is the repeating unit. The mechanism by which RNA polymerase II (RNAPII) transcribes the nucleosomal DNA remains unclear. Here we report the cryo-electron microscopy structures of RNAPII-nucleosome complexes in which RNAPII pauses at the superheli...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-11, Vol.362 (6414), p.595-598
Hauptverfasser:	Kujirai, Tomoya, Ehara, Haruhiko, Fujino, Yuka, Shirouzu, Mikako, Sekine, Shun-Ichi, Kurumizaka, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatin Chromatin - genetics Cryoelectron Microscopy Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA-directed RNA polymerase Electron microscopy Epigenesis, Genetic Eukaryotes Gene regulation Histones - chemistry Histones - metabolism Humans Microscopy Nucleosomes Nucleosomes - chemistry Nucleosomes - metabolism Nucleosomes - ultrastructure Ribonucleic acid RNA RNA polymerase RNA polymerase II RNA Polymerase II - chemistry RNA Polymerase II - metabolism RNA Polymerase II - ultrastructure Superhelical DNA Transcription Transcription, Genetic
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