Real-Time US-18FDG-PET/CT Image Fusion for Guidance of Thermal Ablation of 18FDG-PET-Positive Liver Metastases: The Added Value of Contrast Enhancement
Purpose To assess the feasibility of US- 18 FDG-PET/CT fusion-guided microwave ablation of liver metastases either poorly visible or totally undetectable with US, CEUS and CT, but visualized by PET imaging. Materials and Methods Twenty-three patients with 58 liver metastases underwent microwave abla...
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2019, Vol.42 (1), p.60-68 |
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| creator | Mauri, Giovanni Gennaro, Nicolò De Beni, Stefano Ierace, Tiziana Goldberg, S. Nahum Rodari, Marcello Solbiati, Luigi Alessandro |
| description | Purpose
To assess the feasibility of US-
18
FDG-PET/CT fusion-guided microwave ablation of liver metastases either poorly visible or totally undetectable with US, CEUS and CT, but visualized by PET imaging.
Materials and Methods
Twenty-three patients with 58 liver metastases underwent microwave ablation guided by image fusion system that combines US with
18
FDG-PET/CT images. In 28/58 tumors,
18
FDG-PET/CT with contrast medium (PET/CECT) was used. The registration technical feasibility, registration time, rates of correct targeting, technical success at 24 h, final result at 1 year and complications were analyzed and compared between the PET/CT and PET/CECT groups.
Results
Registration was successfully performed in all cases with a mean time of 7.8 + 1.7 min (mean + standard deviation), (4.6 + 1.5 min for PET/CECT group versus 10.9 + 1.8 min for PET/CT group,
P
|
| doi_str_mv | 10.1007/s00270-018-2082-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2116846404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2116259966</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1941-ee147ed3fd2e5b0e3a760aea959976558fa92447cb4cdb5e9798d854eedc40583</originalsourceid><addsrcrecordid>eNp1kdFKHDEUhkOx0FX7AL0L9KY30ZxsMpPxbll3V2FFacfSu5CdnNGRmYkmM0KfpK9rxi0WhEI4gcP3_Qn8hHwBfgKc56eRc5FzxkEzwbVg8IHMQM4F4zr7dUBmHHLJQCn4RA5jfOAclBZqRv58R9uysumQ3v5goNfnG3azKk-XJb3s7B3S9Rgb39PaB7oZG2f7CqmvaXmPobMtXexaO0xA2r3Z7MbHZmiekW7TCPQKBxvTwXg2iXThHDr607bja9bS90NIAF3191N-h_1wTD7Wto34-e99RG7Xq3J5wbbXm8vlYssqKCQwRJA5unntBKodx7nNM27RFqoo8kwpXdtCSJlXO1m5ncIiL7TTSiK6SnKl50fk2z73MfinEeNguiZW2La2Rz9GIwAyLTPJZUK_vkMf_Bj69LtXSqQnsyxRsKeq4GMMWJvH0HQ2_DbAzVSV2VdlUlVmqspAcsTeiYnt7zD8S_6_9ALjW5P8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2116259966</pqid></control><display><type>article</type><title>Real-Time US-18FDG-PET/CT Image Fusion for Guidance of Thermal Ablation of 18FDG-PET-Positive Liver Metastases: The Added Value of Contrast Enhancement</title><source>Springer Nature - Complete Springer Journals</source><creator>Mauri, Giovanni ; Gennaro, Nicolò ; De Beni, Stefano ; Ierace, Tiziana ; Goldberg, S. Nahum ; Rodari, Marcello ; Solbiati, Luigi Alessandro</creator><creatorcontrib>Mauri, Giovanni ; Gennaro, Nicolò ; De Beni, Stefano ; Ierace, Tiziana ; Goldberg, S. Nahum ; Rodari, Marcello ; Solbiati, Luigi Alessandro</creatorcontrib><description>Purpose
To assess the feasibility of US-
18
FDG-PET/CT fusion-guided microwave ablation of liver metastases either poorly visible or totally undetectable with US, CEUS and CT, but visualized by PET imaging.
Materials and Methods
Twenty-three patients with 58 liver metastases underwent microwave ablation guided by image fusion system that combines US with
18
FDG-PET/CT images. In 28/58 tumors,
18
FDG-PET/CT with contrast medium (PET/CECT) was used. The registration technical feasibility, registration time, rates of correct targeting, technical success at 24 h, final result at 1 year and complications were analyzed and compared between the PET/CT and PET/CECT groups.
Results
Registration was successfully performed in all cases with a mean time of 7.8 + 1.7 min (mean + standard deviation), (4.6 + 1.5 min for PET/CECT group versus 10.9 + 1.8 min for PET/CT group,
P
< 0.01). In total, 46/58 (79.3%) tumors were correctly targeted, while 3/28 (10.7%) and 9/30 (30%) were incorrectly targeted in PET/CT and PET/CECT group, respectively (
P
< 0.05). Complete ablation was obtained at 24 h in 70.0% of cases (
n
= 40 tumors), 23/28 (82.1%) in the PET/CECT group and 17/30 (56.7%) in the PET/CT group (
P
< 0.037). Fourteen tumors underwent local retreatment (11 ablations, 2 with resection and 1 with stereotactic body radiation therapy), while 4 tumors could not be retreated because of distant disease progression and underwent systemic therapy. Finally, 54/58 (93.1%) tumors were completely treated at 1 year. One major complication occurred, a gastrointestinal hemorrhage which required surgical repair.
Conclusions
Percutaneous ablation of
18
FDG-PET-positive liver metastases using fusion imaging of real-time US and pre-acquired
18
FDG-PET/CT images is feasible, safe and effective. Contrast-enhanced PET/CT improves overall ablation accuracy and shortens procedural duration time.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-018-2082-1</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Ablation ; Amputation ; Cardiology ; Clinical Investigation ; Complications ; Computed tomography ; Computer vision ; Feasibility studies ; Hemorrhage ; Image acquisition ; Image contrast ; Image enhancement ; Image processing ; Imaging ; Interventional Oncology ; Liver ; Medical imaging ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Nuclear Medicine ; Positron emission ; Radiation ; Radiation therapy ; Radiology ; Real time ; Registration ; Surgery ; Tomography ; Tumors ; Ultrasound</subject><ispartof>Cardiovascular and interventional radiology, 2019, Vol.42 (1), p.60-68</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018</rights><rights>CardioVascular and Interventional Radiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1941-ee147ed3fd2e5b0e3a760aea959976558fa92447cb4cdb5e9798d854eedc40583</citedby><cites>FETCH-LOGICAL-c1941-ee147ed3fd2e5b0e3a760aea959976558fa92447cb4cdb5e9798d854eedc40583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-018-2082-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-018-2082-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids></links><search><creatorcontrib>Mauri, Giovanni</creatorcontrib><creatorcontrib>Gennaro, Nicolò</creatorcontrib><creatorcontrib>De Beni, Stefano</creatorcontrib><creatorcontrib>Ierace, Tiziana</creatorcontrib><creatorcontrib>Goldberg, S. Nahum</creatorcontrib><creatorcontrib>Rodari, Marcello</creatorcontrib><creatorcontrib>Solbiati, Luigi Alessandro</creatorcontrib><title>Real-Time US-18FDG-PET/CT Image Fusion for Guidance of Thermal Ablation of 18FDG-PET-Positive Liver Metastases: The Added Value of Contrast Enhancement</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
To assess the feasibility of US-
18
FDG-PET/CT fusion-guided microwave ablation of liver metastases either poorly visible or totally undetectable with US, CEUS and CT, but visualized by PET imaging.
Materials and Methods
Twenty-three patients with 58 liver metastases underwent microwave ablation guided by image fusion system that combines US with
18
FDG-PET/CT images. In 28/58 tumors,
18
FDG-PET/CT with contrast medium (PET/CECT) was used. The registration technical feasibility, registration time, rates of correct targeting, technical success at 24 h, final result at 1 year and complications were analyzed and compared between the PET/CT and PET/CECT groups.
Results
Registration was successfully performed in all cases with a mean time of 7.8 + 1.7 min (mean + standard deviation), (4.6 + 1.5 min for PET/CECT group versus 10.9 + 1.8 min for PET/CT group,
P
< 0.01). In total, 46/58 (79.3%) tumors were correctly targeted, while 3/28 (10.7%) and 9/30 (30%) were incorrectly targeted in PET/CT and PET/CECT group, respectively (
P
< 0.05). Complete ablation was obtained at 24 h in 70.0% of cases (
n
= 40 tumors), 23/28 (82.1%) in the PET/CECT group and 17/30 (56.7%) in the PET/CT group (
P
< 0.037). Fourteen tumors underwent local retreatment (11 ablations, 2 with resection and 1 with stereotactic body radiation therapy), while 4 tumors could not be retreated because of distant disease progression and underwent systemic therapy. Finally, 54/58 (93.1%) tumors were completely treated at 1 year. One major complication occurred, a gastrointestinal hemorrhage which required surgical repair.
Conclusions
Percutaneous ablation of
18
FDG-PET-positive liver metastases using fusion imaging of real-time US and pre-acquired
18
FDG-PET/CT images is feasible, safe and effective. Contrast-enhanced PET/CT improves overall ablation accuracy and shortens procedural duration time.</description><subject>Ablation</subject><subject>Amputation</subject><subject>Cardiology</subject><subject>Clinical Investigation</subject><subject>Complications</subject><subject>Computed tomography</subject><subject>Computer vision</subject><subject>Feasibility studies</subject><subject>Hemorrhage</subject><subject>Image acquisition</subject><subject>Image contrast</subject><subject>Image enhancement</subject><subject>Image processing</subject><subject>Imaging</subject><subject>Interventional Oncology</subject><subject>Liver</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Nuclear Medicine</subject><subject>Positron emission</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Radiology</subject><subject>Real time</subject><subject>Registration</subject><subject>Surgery</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Ultrasound</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kdFKHDEUhkOx0FX7AL0L9KY30ZxsMpPxbll3V2FFacfSu5CdnNGRmYkmM0KfpK9rxi0WhEI4gcP3_Qn8hHwBfgKc56eRc5FzxkEzwbVg8IHMQM4F4zr7dUBmHHLJQCn4RA5jfOAclBZqRv58R9uysumQ3v5goNfnG3azKk-XJb3s7B3S9Rgb39PaB7oZG2f7CqmvaXmPobMtXexaO0xA2r3Z7MbHZmiekW7TCPQKBxvTwXg2iXThHDr607bja9bS90NIAF3191N-h_1wTD7Wto34-e99RG7Xq3J5wbbXm8vlYssqKCQwRJA5unntBKodx7nNM27RFqoo8kwpXdtCSJlXO1m5ncIiL7TTSiK6SnKl50fk2z73MfinEeNguiZW2La2Rz9GIwAyLTPJZUK_vkMf_Bj69LtXSqQnsyxRsKeq4GMMWJvH0HQ2_DbAzVSV2VdlUlVmqspAcsTeiYnt7zD8S_6_9ALjW5P8</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Mauri, Giovanni</creator><creator>Gennaro, Nicolò</creator><creator>De Beni, Stefano</creator><creator>Ierace, Tiziana</creator><creator>Goldberg, S. Nahum</creator><creator>Rodari, Marcello</creator><creator>Solbiati, Luigi Alessandro</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2019</creationdate><title>Real-Time US-18FDG-PET/CT Image Fusion for Guidance of Thermal Ablation of 18FDG-PET-Positive Liver Metastases: The Added Value of Contrast Enhancement</title><author>Mauri, Giovanni ; Gennaro, Nicolò ; De Beni, Stefano ; Ierace, Tiziana ; Goldberg, S. Nahum ; Rodari, Marcello ; Solbiati, Luigi Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1941-ee147ed3fd2e5b0e3a760aea959976558fa92447cb4cdb5e9798d854eedc40583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ablation</topic><topic>Amputation</topic><topic>Cardiology</topic><topic>Clinical Investigation</topic><topic>Complications</topic><topic>Computed tomography</topic><topic>Computer vision</topic><topic>Feasibility studies</topic><topic>Hemorrhage</topic><topic>Image acquisition</topic><topic>Image contrast</topic><topic>Image enhancement</topic><topic>Image processing</topic><topic>Imaging</topic><topic>Interventional Oncology</topic><topic>Liver</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Nuclear Medicine</topic><topic>Positron emission</topic><topic>Radiation</topic><topic>Radiation therapy</topic><topic>Radiology</topic><topic>Real time</topic><topic>Registration</topic><topic>Surgery</topic><topic>Tomography</topic><topic>Tumors</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mauri, Giovanni</creatorcontrib><creatorcontrib>Gennaro, Nicolò</creatorcontrib><creatorcontrib>De Beni, Stefano</creatorcontrib><creatorcontrib>Ierace, Tiziana</creatorcontrib><creatorcontrib>Goldberg, S. Nahum</creatorcontrib><creatorcontrib>Rodari, Marcello</creatorcontrib><creatorcontrib>Solbiati, Luigi Alessandro</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mauri, Giovanni</au><au>Gennaro, Nicolò</au><au>De Beni, Stefano</au><au>Ierace, Tiziana</au><au>Goldberg, S. Nahum</au><au>Rodari, Marcello</au><au>Solbiati, Luigi Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real-Time US-18FDG-PET/CT Image Fusion for Guidance of Thermal Ablation of 18FDG-PET-Positive Liver Metastases: The Added Value of Contrast Enhancement</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><date>2019</date><risdate>2019</risdate><volume>42</volume><issue>1</issue><spage>60</spage><epage>68</epage><pages>60-68</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
To assess the feasibility of US-
18
FDG-PET/CT fusion-guided microwave ablation of liver metastases either poorly visible or totally undetectable with US, CEUS and CT, but visualized by PET imaging.
Materials and Methods
Twenty-three patients with 58 liver metastases underwent microwave ablation guided by image fusion system that combines US with
18
FDG-PET/CT images. In 28/58 tumors,
18
FDG-PET/CT with contrast medium (PET/CECT) was used. The registration technical feasibility, registration time, rates of correct targeting, technical success at 24 h, final result at 1 year and complications were analyzed and compared between the PET/CT and PET/CECT groups.
Results
Registration was successfully performed in all cases with a mean time of 7.8 + 1.7 min (mean + standard deviation), (4.6 + 1.5 min for PET/CECT group versus 10.9 + 1.8 min for PET/CT group,
P
< 0.01). In total, 46/58 (79.3%) tumors were correctly targeted, while 3/28 (10.7%) and 9/30 (30%) were incorrectly targeted in PET/CT and PET/CECT group, respectively (
P
< 0.05). Complete ablation was obtained at 24 h in 70.0% of cases (
n
= 40 tumors), 23/28 (82.1%) in the PET/CECT group and 17/30 (56.7%) in the PET/CT group (
P
< 0.037). Fourteen tumors underwent local retreatment (11 ablations, 2 with resection and 1 with stereotactic body radiation therapy), while 4 tumors could not be retreated because of distant disease progression and underwent systemic therapy. Finally, 54/58 (93.1%) tumors were completely treated at 1 year. One major complication occurred, a gastrointestinal hemorrhage which required surgical repair.
Conclusions
Percutaneous ablation of
18
FDG-PET-positive liver metastases using fusion imaging of real-time US and pre-acquired
18
FDG-PET/CT images is feasible, safe and effective. Contrast-enhanced PET/CT improves overall ablation accuracy and shortens procedural duration time.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00270-018-2082-1</doi><tpages>9</tpages></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Ablation Amputation Cardiology Clinical Investigation Complications Computed tomography Computer vision Feasibility studies Hemorrhage Image acquisition Image contrast Image enhancement Image processing Imaging Interventional Oncology Liver Medical imaging Medicine Medicine & Public Health Metastases Metastasis Nuclear Medicine Positron emission Radiation Radiation therapy Radiology Real time Registration Surgery Tomography Tumors Ultrasound |
| title | Real-Time US-18FDG-PET/CT Image Fusion for Guidance of Thermal Ablation of 18FDG-PET-Positive Liver Metastases: The Added Value of Contrast Enhancement |
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