Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus
This study was carried out to evaluate the potential antibacterial and immunomodulatory effects of the dietary acidifier propionic acid (PA) when given alone or in combination with oxytetracycline (OTC) on Nile tilapia ( Oreochromis niloticus ). Apparently healthy O. niloticus ( n = 240; 52 ± 3.75 ...
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| Veröffentlicht in: | Environmental science and pollution research international 2018-12, Vol.25 (34), p.34200-34211 |
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| creator | El-Adawy, Mohammed El-Aziz, Magdy Abd El-Shazly, Kamal Ali, Nadia G. El-Magd, Mohammed Abu |
| description | This study was carried out to evaluate the potential antibacterial and immunomodulatory effects of the dietary acidifier propionic acid (PA) when given alone or in combination with oxytetracycline (OTC) on Nile tilapia (
Oreochromis niloticus
). Apparently healthy
O. niloticus
(
n =
240; 52 ± 3.75 g) were randomly allocated into four equal groups (
n =
60/group): control group fed a basal diet alone and the other three groups fed basal diets supplemented with either PA (200 mg /kg of diet, PA group) or OTC (500 mg/kg of diet, OTC group) alone or in combination (PA + OTC group). Each group was subdivided into two subgroups (
n =
30/subgroup, each subgroup had triplicate of 10 fish); subgroup (A) was used to evaluate the antibacterial effects with the aforementioned 2 weeks feeding regime, and subgroup (B) was used to evaluate the immunomodulatory effects against
Aeromonas hydrophila
infection with similar 2 weeks feeding regime. Among the four groups, PA + OTC group showed the highest significant (
p
|
| doi_str_mv | 10.1007/s11356-018-3206-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2116845611</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2133745399</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-3f70a3d1b50e1aceceead0ce214573d387c5cef083318ca8a1211317bfb339f03</originalsourceid><addsrcrecordid>eNp1kU9rFTEUxYMo9vXpB3AjATcuOppMMpOZZam2FYrd6Dpk7ty0KZnkmWTAt_eDm_JaCwVX4ZLfOffPIeQdZ584Y-pz5lx0fcP40IiW9U33gmx4z2Wj5Di-JBs2StlwIeUROc75jrGWja16TY4Ea4ehV3JD_nxxWEza012KOxeDA2rAzRTDrQmAmZpQ3GSgYHLG12qmblnWEJc4r96UWKVoLULJNFoaf-8LlmRgD94FpDHQ784jLc6bnTMn9DphhNsUF5dpcD4WB2t-Q15Z4zO-fXi35Of51x9nl83V9cW3s9OrBqRSpRFWMSNmPnUMuQEERDMzwJbLTolZDAo6QMsGIfgAZjC8rQfiarKTEKNlYks-Hnzrsr9WzEXXMQC9NwHjmnXF-0F2fVVtyYdn6F1cU6jTVUoIJTsxjpXiBwpSzDmh1bvklnpOzZm-j0gfItI1In0fke6q5v2D8zotOP9TPGZSgfYA5PoVbjA9tf6_61-1Tp7b</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2133745399</pqid></control><display><type>article</type><title>Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>El-Adawy, Mohammed ; El-Aziz, Magdy Abd ; El-Shazly, Kamal ; Ali, Nadia G. ; El-Magd, Mohammed Abu</creator><creatorcontrib>El-Adawy, Mohammed ; El-Aziz, Magdy Abd ; El-Shazly, Kamal ; Ali, Nadia G. ; El-Magd, Mohammed Abu</creatorcontrib><description>This study was carried out to evaluate the potential antibacterial and immunomodulatory effects of the dietary acidifier propionic acid (PA) when given alone or in combination with oxytetracycline (OTC) on Nile tilapia (
Oreochromis niloticus
). Apparently healthy
O. niloticus
(
n =
240; 52 ± 3.75 g) were randomly allocated into four equal groups (
n =
60/group): control group fed a basal diet alone and the other three groups fed basal diets supplemented with either PA (200 mg /kg of diet, PA group) or OTC (500 mg/kg of diet, OTC group) alone or in combination (PA + OTC group). Each group was subdivided into two subgroups (
n =
30/subgroup, each subgroup had triplicate of 10 fish); subgroup (A) was used to evaluate the antibacterial effects with the aforementioned 2 weeks feeding regime, and subgroup (B) was used to evaluate the immunomodulatory effects against
Aeromonas hydrophila
infection with similar 2 weeks feeding regime. Among the four groups, PA + OTC group showed the highest significant (
p
< 0.0001) antibacterial activity as indicated by widest inhibition zones against
A. hydrophila
and lowest total gastrointestinal bacterial counts. Additionally, this group had the best immunomodulatory effect as noticed by a significant (
p
< 0.05) increase in total serum protein, globulin, IgM, phagocytic activity and index, lysosome activity, and significant (
p
< 0.05) upregulation in the expression levels of immunity-related genes (
MHC I, MHC IIA, MHC IIB, Tlr7, IgM heavy chain
,
TNFα
, and
IL1β
) in head-kidney. Notably, the combined dietary PA and OTC improved the hematological parameters and reduced the oxidative damage of hepatopancreas and head-kidney induced by OTC. This data suggests dietary PA as potential adjuvant to OTC in
O. niloticus
diets to get maximal antibacterial and immunomodulatory effects.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-018-3206-5</identifier><identifier>PMID: 30288674</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acidification ; Aeromonas hydrophila - pathogenicity ; Animal Feed - analysis ; Animals ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Cichlids - immunology ; Cichlids - microbiology ; Diet ; Dietary Supplements - analysis ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Feeding ; Fish ; Fish Diseases - microbiology ; Fish Diseases - prevention & control ; Gene expression ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - immunology ; Globulins ; Gram-Negative Bacterial Infections - prevention & control ; Gram-Negative Bacterial Infections - veterinary ; Hepatopancreas ; Immunity ; Immunoglobulin M ; Immunologic Factors - pharmacology ; Immunomodulation ; Interleukin 1 ; Kidney - drug effects ; Kidney - physiology ; Kidneys ; Liver - drug effects ; Major histocompatibility complex ; Oreochromis niloticus ; Oxytetracycline ; Oxytetracycline - immunology ; Oxytetracycline - pharmacology ; Phagocytes ; Phagocytosis - drug effects ; Ponds ; Propionates - pharmacology ; Propionic acid ; Proteins ; Research Article ; Subgroups ; Tilapia ; TLR7 protein ; Toll-like receptors ; Tumor necrosis factor-α ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2018-12, Vol.25 (34), p.34200-34211</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-3f70a3d1b50e1aceceead0ce214573d387c5cef083318ca8a1211317bfb339f03</citedby><cites>FETCH-LOGICAL-c477t-3f70a3d1b50e1aceceead0ce214573d387c5cef083318ca8a1211317bfb339f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-018-3206-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-018-3206-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30288674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Adawy, Mohammed</creatorcontrib><creatorcontrib>El-Aziz, Magdy Abd</creatorcontrib><creatorcontrib>El-Shazly, Kamal</creatorcontrib><creatorcontrib>Ali, Nadia G.</creatorcontrib><creatorcontrib>El-Magd, Mohammed Abu</creatorcontrib><title>Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>This study was carried out to evaluate the potential antibacterial and immunomodulatory effects of the dietary acidifier propionic acid (PA) when given alone or in combination with oxytetracycline (OTC) on Nile tilapia (
Oreochromis niloticus
). Apparently healthy
O. niloticus
(
n =
240; 52 ± 3.75 g) were randomly allocated into four equal groups (
n =
60/group): control group fed a basal diet alone and the other three groups fed basal diets supplemented with either PA (200 mg /kg of diet, PA group) or OTC (500 mg/kg of diet, OTC group) alone or in combination (PA + OTC group). Each group was subdivided into two subgroups (
n =
30/subgroup, each subgroup had triplicate of 10 fish); subgroup (A) was used to evaluate the antibacterial effects with the aforementioned 2 weeks feeding regime, and subgroup (B) was used to evaluate the immunomodulatory effects against
Aeromonas hydrophila
infection with similar 2 weeks feeding regime. Among the four groups, PA + OTC group showed the highest significant (
p
< 0.0001) antibacterial activity as indicated by widest inhibition zones against
A. hydrophila
and lowest total gastrointestinal bacterial counts. Additionally, this group had the best immunomodulatory effect as noticed by a significant (
p
< 0.05) increase in total serum protein, globulin, IgM, phagocytic activity and index, lysosome activity, and significant (
p
< 0.05) upregulation in the expression levels of immunity-related genes (
MHC I, MHC IIA, MHC IIB, Tlr7, IgM heavy chain
,
TNFα
, and
IL1β
) in head-kidney. Notably, the combined dietary PA and OTC improved the hematological parameters and reduced the oxidative damage of hepatopancreas and head-kidney induced by OTC. This data suggests dietary PA as potential adjuvant to OTC in
O. niloticus
diets to get maximal antibacterial and immunomodulatory effects.</description><subject>Acidification</subject><subject>Aeromonas hydrophila - pathogenicity</subject><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Cichlids - immunology</subject><subject>Cichlids - microbiology</subject><subject>Diet</subject><subject>Dietary Supplements - analysis</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Feeding</subject><subject>Fish</subject><subject>Fish Diseases - microbiology</subject><subject>Fish Diseases - prevention & control</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - immunology</subject><subject>Globulins</subject><subject>Gram-Negative Bacterial Infections - prevention & control</subject><subject>Gram-Negative Bacterial Infections - veterinary</subject><subject>Hepatopancreas</subject><subject>Immunity</subject><subject>Immunoglobulin M</subject><subject>Immunologic Factors - pharmacology</subject><subject>Immunomodulation</subject><subject>Interleukin 1</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiology</subject><subject>Kidneys</subject><subject>Liver - drug effects</subject><subject>Major histocompatibility complex</subject><subject>Oreochromis niloticus</subject><subject>Oxytetracycline</subject><subject>Oxytetracycline - immunology</subject><subject>Oxytetracycline - pharmacology</subject><subject>Phagocytes</subject><subject>Phagocytosis - drug effects</subject><subject>Ponds</subject><subject>Propionates - pharmacology</subject><subject>Propionic acid</subject><subject>Proteins</subject><subject>Research Article</subject><subject>Subgroups</subject><subject>Tilapia</subject><subject>TLR7 protein</subject><subject>Toll-like receptors</subject><subject>Tumor necrosis factor-α</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU9rFTEUxYMo9vXpB3AjATcuOppMMpOZZam2FYrd6Dpk7ty0KZnkmWTAt_eDm_JaCwVX4ZLfOffPIeQdZ584Y-pz5lx0fcP40IiW9U33gmx4z2Wj5Di-JBs2StlwIeUROc75jrGWja16TY4Ea4ehV3JD_nxxWEza012KOxeDA2rAzRTDrQmAmZpQ3GSgYHLG12qmblnWEJc4r96UWKVoLULJNFoaf-8LlmRgD94FpDHQ784jLc6bnTMn9DphhNsUF5dpcD4WB2t-Q15Z4zO-fXi35Of51x9nl83V9cW3s9OrBqRSpRFWMSNmPnUMuQEERDMzwJbLTolZDAo6QMsGIfgAZjC8rQfiarKTEKNlYks-Hnzrsr9WzEXXMQC9NwHjmnXF-0F2fVVtyYdn6F1cU6jTVUoIJTsxjpXiBwpSzDmh1bvklnpOzZm-j0gfItI1In0fke6q5v2D8zotOP9TPGZSgfYA5PoVbjA9tf6_61-1Tp7b</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>El-Adawy, Mohammed</creator><creator>El-Aziz, Magdy Abd</creator><creator>El-Shazly, Kamal</creator><creator>Ali, Nadia G.</creator><creator>El-Magd, Mohammed Abu</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20181201</creationdate><title>Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus</title><author>El-Adawy, Mohammed ; El-Aziz, Magdy Abd ; El-Shazly, Kamal ; Ali, Nadia G. ; El-Magd, Mohammed Abu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-3f70a3d1b50e1aceceead0ce214573d387c5cef083318ca8a1211317bfb339f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acidification</topic><topic>Aeromonas hydrophila - pathogenicity</topic><topic>Animal Feed - analysis</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Cichlids - immunology</topic><topic>Cichlids - microbiology</topic><topic>Diet</topic><topic>Dietary Supplements - analysis</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Feeding</topic><topic>Fish</topic><topic>Fish Diseases - microbiology</topic><topic>Fish Diseases - prevention & control</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - immunology</topic><topic>Globulins</topic><topic>Gram-Negative Bacterial Infections - prevention & control</topic><topic>Gram-Negative Bacterial Infections - veterinary</topic><topic>Hepatopancreas</topic><topic>Immunity</topic><topic>Immunoglobulin M</topic><topic>Immunologic Factors - pharmacology</topic><topic>Immunomodulation</topic><topic>Interleukin 1</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiology</topic><topic>Kidneys</topic><topic>Liver - drug effects</topic><topic>Major histocompatibility complex</topic><topic>Oreochromis niloticus</topic><topic>Oxytetracycline</topic><topic>Oxytetracycline - immunology</topic><topic>Oxytetracycline - pharmacology</topic><topic>Phagocytes</topic><topic>Phagocytosis - drug effects</topic><topic>Ponds</topic><topic>Propionates - pharmacology</topic><topic>Propionic acid</topic><topic>Proteins</topic><topic>Research Article</topic><topic>Subgroups</topic><topic>Tilapia</topic><topic>TLR7 protein</topic><topic>Toll-like receptors</topic><topic>Tumor necrosis factor-α</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Adawy, Mohammed</creatorcontrib><creatorcontrib>El-Aziz, Magdy Abd</creatorcontrib><creatorcontrib>El-Shazly, Kamal</creatorcontrib><creatorcontrib>Ali, Nadia G.</creatorcontrib><creatorcontrib>El-Magd, Mohammed Abu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Adawy, Mohammed</au><au>El-Aziz, Magdy Abd</au><au>El-Shazly, Kamal</au><au>Ali, Nadia G.</au><au>El-Magd, Mohammed Abu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>25</volume><issue>34</issue><spage>34200</spage><epage>34211</epage><pages>34200-34211</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>This study was carried out to evaluate the potential antibacterial and immunomodulatory effects of the dietary acidifier propionic acid (PA) when given alone or in combination with oxytetracycline (OTC) on Nile tilapia (
Oreochromis niloticus
). Apparently healthy
O. niloticus
(
n =
240; 52 ± 3.75 g) were randomly allocated into four equal groups (
n =
60/group): control group fed a basal diet alone and the other three groups fed basal diets supplemented with either PA (200 mg /kg of diet, PA group) or OTC (500 mg/kg of diet, OTC group) alone or in combination (PA + OTC group). Each group was subdivided into two subgroups (
n =
30/subgroup, each subgroup had triplicate of 10 fish); subgroup (A) was used to evaluate the antibacterial effects with the aforementioned 2 weeks feeding regime, and subgroup (B) was used to evaluate the immunomodulatory effects against
Aeromonas hydrophila
infection with similar 2 weeks feeding regime. Among the four groups, PA + OTC group showed the highest significant (
p
< 0.0001) antibacterial activity as indicated by widest inhibition zones against
A. hydrophila
and lowest total gastrointestinal bacterial counts. Additionally, this group had the best immunomodulatory effect as noticed by a significant (
p
< 0.05) increase in total serum protein, globulin, IgM, phagocytic activity and index, lysosome activity, and significant (
p
< 0.05) upregulation in the expression levels of immunity-related genes (
MHC I, MHC IIA, MHC IIB, Tlr7, IgM heavy chain
,
TNFα
, and
IL1β
) in head-kidney. Notably, the combined dietary PA and OTC improved the hematological parameters and reduced the oxidative damage of hepatopancreas and head-kidney induced by OTC. This data suggests dietary PA as potential adjuvant to OTC in
O. niloticus
diets to get maximal antibacterial and immunomodulatory effects.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30288674</pmid><doi>10.1007/s11356-018-3206-5</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2018-12, Vol.25 (34), p.34200-34211 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2116845611 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Acidification Aeromonas hydrophila - pathogenicity Animal Feed - analysis Animals Anti-Bacterial Agents - pharmacology Antibacterial activity Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Cichlids - immunology Cichlids - microbiology Diet Dietary Supplements - analysis Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Feeding Fish Fish Diseases - microbiology Fish Diseases - prevention & control Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Globulins Gram-Negative Bacterial Infections - prevention & control Gram-Negative Bacterial Infections - veterinary Hepatopancreas Immunity Immunoglobulin M Immunologic Factors - pharmacology Immunomodulation Interleukin 1 Kidney - drug effects Kidney - physiology Kidneys Liver - drug effects Major histocompatibility complex Oreochromis niloticus Oxytetracycline Oxytetracycline - immunology Oxytetracycline - pharmacology Phagocytes Phagocytosis - drug effects Ponds Propionates - pharmacology Propionic acid Proteins Research Article Subgroups Tilapia TLR7 protein Toll-like receptors Tumor necrosis factor-α Waste Water Technology Water Management Water Pollution Control |
| title | Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T12%3A01%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20propionic%20acid%20enhances%20antibacterial%20and%20immunomodulatory%20effects%20of%20oxytetracycline%20on%20Nile%20tilapia,%20Oreochromis%20niloticus&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=El-Adawy,%20Mohammed&rft.date=2018-12-01&rft.volume=25&rft.issue=34&rft.spage=34200&rft.epage=34211&rft.pages=34200-34211&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-018-3206-5&rft_dat=%3Cproquest_cross%3E2133745399%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2133745399&rft_id=info:pmid/30288674&rfr_iscdi=true |