Toward the potential cure of leukemias in the next decade
Historically, progress in leukemia research has been slow, but it has accelerated recently as a result of understanding the pathophysiology of leukemias and implementing more effective and targeted therapies. This review summarizes the progress across leukemia subsets and projects the potential cure...
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| Veröffentlicht in: | Cancer 2018-11, Vol.124 (22), p.4301-4313 |
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| container_issue | 22 |
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| container_title | Cancer |
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| creator | Kantarjian, Hagop M. Keating, Michael J. Freireich, Emil J |
| description | Historically, progress in leukemia research has been slow, but it has accelerated recently as a result of understanding the pathophysiology of leukemias and implementing more effective and targeted therapies. This review summarizes the progress across leukemia subsets and projects the potential cure of most leukemias in the next decade.
This review summarizes the major progress toward the curing all leukemias in the foreseeable future. The therapeutic tools necessary to cure most, if not all, leukemias within the next decade already may be available, and these need to be investigated in combination with both established treatments and other investigational agents in well designed regimens to define new standard‐of‐care curative regimens across all leukemias. |
| doi_str_mv | 10.1002/cncr.31669 |
| format | Article |
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This review summarizes the major progress toward the curing all leukemias in the foreseeable future. The therapeutic tools necessary to cure most, if not all, leukemias within the next decade already may be available, and these need to be investigated in combination with both established treatments and other investigational agents in well designed regimens to define new standard‐of‐care curative regimens across all leukemias.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.31669</identifier><identifier>PMID: 30291792</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>cure ; Historical account ; Leukemia ; leukemias ; Oncology ; targeted ; therapy ; treatments</subject><ispartof>Cancer, 2018-11, Vol.124 (22), p.4301-4313</ispartof><rights>2018 American Cancer Society</rights><rights>2018 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3939-6d4e212e0ca06441f707c4ee4488b33d0a28ba892d37aed911da14b644750cb83</citedby><cites>FETCH-LOGICAL-c3939-6d4e212e0ca06441f707c4ee4488b33d0a28ba892d37aed911da14b644750cb83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.31669$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.31669$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30291792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kantarjian, Hagop M.</creatorcontrib><creatorcontrib>Keating, Michael J.</creatorcontrib><creatorcontrib>Freireich, Emil J</creatorcontrib><title>Toward the potential cure of leukemias in the next decade</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Historically, progress in leukemia research has been slow, but it has accelerated recently as a result of understanding the pathophysiology of leukemias and implementing more effective and targeted therapies. This review summarizes the progress across leukemia subsets and projects the potential cure of most leukemias in the next decade.
This review summarizes the major progress toward the curing all leukemias in the foreseeable future. The therapeutic tools necessary to cure most, if not all, leukemias within the next decade already may be available, and these need to be investigated in combination with both established treatments and other investigational agents in well designed regimens to define new standard‐of‐care curative regimens across all leukemias.</description><subject>cure</subject><subject>Historical account</subject><subject>Leukemia</subject><subject>leukemias</subject><subject>Oncology</subject><subject>targeted</subject><subject>therapy</subject><subject>treatments</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp90M1LwzAYx_EgipvTi3-AFLyIUM1b2-QoxTcYCjLBW0iTp9jZtTNpmfvvzdbpwYOnEPjw5eGH0CnBVwRjem0a464YSVO5h8YEyyzGhNN9NMYYizjh7G2Ejryfh29GE3aIRgxTSTJJx0jO2pV2NureIVq2HTRdpevI9A6itoxq6D9gUWkfVc2WNPDVRRaMtnCMDkpdezjZvRP0enc7yx_i6fP9Y34zjQ2TTMap5UAJBWw0TjknZYYzwwE4F6JgzGJNRaGFpJZlGqwkxGrCi0CzBJtCsAm6GLpL13724Du1qLyButYNtL1XlJBUcCYEDfT8D523vWvCdUExmUiGExLU5aCMa713UKqlqxbarRXBajOo2gyqtoMGfLZL9sUC7C_9WTAAMoBVVcP6n5TKn_KXIfoNLUZ99w</recordid><startdate>20181115</startdate><enddate>20181115</enddate><creator>Kantarjian, Hagop M.</creator><creator>Keating, Michael J.</creator><creator>Freireich, Emil J</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20181115</creationdate><title>Toward the potential cure of leukemias in the next decade</title><author>Kantarjian, Hagop M. ; Keating, Michael J. ; Freireich, Emil J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3939-6d4e212e0ca06441f707c4ee4488b33d0a28ba892d37aed911da14b644750cb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>cure</topic><topic>Historical account</topic><topic>Leukemia</topic><topic>leukemias</topic><topic>Oncology</topic><topic>targeted</topic><topic>therapy</topic><topic>treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kantarjian, Hagop M.</creatorcontrib><creatorcontrib>Keating, Michael J.</creatorcontrib><creatorcontrib>Freireich, Emil J</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kantarjian, Hagop M.</au><au>Keating, Michael J.</au><au>Freireich, Emil J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toward the potential cure of leukemias in the next decade</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2018-11-15</date><risdate>2018</risdate><volume>124</volume><issue>22</issue><spage>4301</spage><epage>4313</epage><pages>4301-4313</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Historically, progress in leukemia research has been slow, but it has accelerated recently as a result of understanding the pathophysiology of leukemias and implementing more effective and targeted therapies. This review summarizes the progress across leukemia subsets and projects the potential cure of most leukemias in the next decade.
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| ispartof | Cancer, 2018-11, Vol.124 (22), p.4301-4313 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2116843882 |
| source | Wiley-Blackwell Journals; Wiley Free Archive; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | cure Historical account Leukemia leukemias Oncology targeted therapy treatments |
| title | Toward the potential cure of leukemias in the next decade |
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