Effect of pulsatile administration of levodopa on dyskinesia induction in drug-naïve MPTP-treated common marmosets: Effect of dose, frequency of administration, and brain exposure

Levodopa (L‐dopa) consistently primes basal ganglia for the appearance of dyskinesia in parkinsonian patients and 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine hydrochloride (MPTP) ‐treated primates. This finding may reflect its relatively short duration of effects resulting in pulsatile stimulation...

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Veröffentlicht in:	Movement disorders 2003-05, Vol.18 (5), p.487-495
Hauptverfasser:	Smith, Lance A., Jackson, Michael J., Hansard, Matthew J., Maratos, Eleni, Jenner, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Antiparkinson Agents - administration & dosage Antiparkinson Agents - metabolism Antiparkinson Agents - pharmacology Biological and medical sciences Callithrix Carbidopa - administration & dosage Carbidopa - metabolism Carbidopa - pharmacology Catechols - administration & dosage Catechols - pharmacology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship, Drug Drug Synergism Drug Therapy, Combination dyskinesia Dyskinesia, Drug-Induced - etiology Dyskinesia, Drug-Induced - prevention & control entacapone Female L-dopa Levodopa - administration & dosage Levodopa - metabolism Levodopa - pharmacology Locomotion - drug effects Male Medical sciences MPTP Neurology Neuropharmacology Nitriles Parkinsonian Disorders - prevention & control Pharmacology. Drug treatments Primates Pulse Therapy, Drug - methods Substantia Nigra - drug effects Time Factors
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