REVIEW: Exploring type I angiotensin (AT sub(1) ) receptor functions through gene targeting

REVIEW: Exploring type I angiotensin (AT sub(1) ) receptor functions through gene targeting

The renin-angiotensin system (RAS) modulates a diverse set of physiological processes including development, blood pressure, renal function and inflammation. The principal effector molecule of this system, angiotensin II, mediates most of these actions. The classically recognized functions of the RA...

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Veröffentlicht in:Acta physiologica Scandinavica 2004-08, Vol.181 (4), p.561-570
Hauptverfasser: Crowley, S D, Tharaux, P, Audoly, L P, Coffman, T M
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Tharaux, P
Audoly, L P
Coffman, T M
description The renin-angiotensin system (RAS) modulates a diverse set of physiological processes including development, blood pressure, renal function and inflammation. The principal effector molecule of this system, angiotensin II, mediates most of these actions. The classically recognized functions of the RAS are triggered via the type 1 (AT sub(1)) class of angiotensin receptors. Pharmacological blockade of the AT sub(1) receptor lowers blood pressure and slows the progression of cardiovascular and renal diseases. Gene-targeting technology provides an experimental approach for precisely dissecting the physiological functions of the RAS. Here, we review how gene-targeting experiments have elucidated AT sub(1) receptor functions.
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title REVIEW: Exploring type I angiotensin (AT sub(1) ) receptor functions through gene targeting
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