The efficacy of nasal airway stent (Nastent) on obstructive sleep apnoea and prediction of treatment outcomes
Summary Background Obstructive sleep apnoea (OSA) is characterised by recurrent episodes of partial or complete upper airway collapse during sleep and is highly prevalent in the general population. The nasopharyngeal airway stent (Nastent) is a specifically designed, preformed silicone tube that int...
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| Veröffentlicht in: | Journal of oral rehabilitation 2019-01, Vol.46 (1), p.51-57 |
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| container_title | Journal of oral rehabilitation |
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| creator | Okuno, Kentaro Ono Minagi, Hitomi Ikai, Kazuki Matsumura Ai, Erika Takai, Etsuko Fukatsu, Hikari Uchida, Yurika Sakai, Takayoshi |
| description | Summary
Background
Obstructive sleep apnoea (OSA) is characterised by recurrent episodes of partial or complete upper airway collapse during sleep and is highly prevalent in the general population. The nasopharyngeal airway stent (Nastent) is a specifically designed, preformed silicone tube that intends to maintain the upper airway patency during sleep and reduce snoring and sleep apnoea.
Objective(s)
The purpose of this study was to determine the efficacy of Nastent treatment and examine predictors for Nastent treatment outcomes in patients with OSA.
Methods
Consecutive thirty patients were enrolled in this study. Cephalometric radiographs were obtained to analyse the pharyngeal and craniofacial morphology. Before and after Nastent treatment, we evaluated OSA using a portable sleep study.
Results
Twenty‐nine subjects completed this study. There were significant decreases in the respiratory event index (REI) (22.4 ± 14.1 to 15.7 ± 10.4, P |
| doi_str_mv | 10.1111/joor.12725 |
| format | Article |
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Background
Obstructive sleep apnoea (OSA) is characterised by recurrent episodes of partial or complete upper airway collapse during sleep and is highly prevalent in the general population. The nasopharyngeal airway stent (Nastent) is a specifically designed, preformed silicone tube that intends to maintain the upper airway patency during sleep and reduce snoring and sleep apnoea.
Objective(s)
The purpose of this study was to determine the efficacy of Nastent treatment and examine predictors for Nastent treatment outcomes in patients with OSA.
Methods
Consecutive thirty patients were enrolled in this study. Cephalometric radiographs were obtained to analyse the pharyngeal and craniofacial morphology. Before and after Nastent treatment, we evaluated OSA using a portable sleep study.
Results
Twenty‐nine subjects completed this study. There were significant decreases in the respiratory event index (REI) (22.4 ± 14.1 to 15.7 ± 10.4, P < 0.01) and a significant increase in the lowest SpO2 (81.9 ± 7.5 to 86.6 ± 4.8, P < 0.01) by Nastent treatment. Subjects were divided into responders and non‐responders based on reduction in REI of >50% compared with baseline REI. We evaluated the ratio of inferior airway width and middle airway width (IAW/MAW) on cephalograms as the index of the narrowest airway site. The IAW/MAW was significantly higher in responders than in non‐responders (1.4 ± 0.9 vs 0.9 ± 0.4, P < 0.01) and predicted treatment responders with high accuracy (sensitivity: 90.9%, specificity: 88.9%, when IAW/MAW was set at 1.10).
Conclusions
The Nastent device improved OSA, and a narrower velopharynx than hypopharynx predicted treatment response with a good sensitivity and specificity.</description><identifier>ISSN: 0305-182X</identifier><identifier>EISSN: 1365-2842</identifier><identifier>DOI: 10.1111/joor.12725</identifier><identifier>PMID: 30281824</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Apnea ; Cephalometry ; Clinical outcomes ; Craniofacial Abnormalities - diagnostic imaging ; Craniofacial Abnormalities - physiopathology ; Dentistry ; Facial Bones - diagnostic imaging ; Female ; Humans ; Hypopharynx ; Implants ; Male ; Middle Aged ; nasal airway stent ; obstructive sleep apnoea ; Patients ; Pharynx ; Pharynx - diagnostic imaging ; Pharynx - physiopathology ; prediction ; Radiography ; Respiratory tract ; Silicones ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - diagnostic imaging ; Sleep Apnea, Obstructive - etiology ; Sleep deprivation ; Sleep disorders ; Snoring ; Stents ; Treatment Outcome</subject><ispartof>Journal of oral rehabilitation, 2019-01, Vol.46 (1), p.51-57</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4595-4ff01f3d6f4a1d283a7d1b3d57086d210e8138829c35a5d30819d203dca268ee3</citedby><cites>FETCH-LOGICAL-c4595-4ff01f3d6f4a1d283a7d1b3d57086d210e8138829c35a5d30819d203dca268ee3</cites><orcidid>0000-0003-1737-7958</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjoor.12725$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjoor.12725$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30281824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okuno, Kentaro</creatorcontrib><creatorcontrib>Ono Minagi, Hitomi</creatorcontrib><creatorcontrib>Ikai, Kazuki</creatorcontrib><creatorcontrib>Matsumura Ai, Erika</creatorcontrib><creatorcontrib>Takai, Etsuko</creatorcontrib><creatorcontrib>Fukatsu, Hikari</creatorcontrib><creatorcontrib>Uchida, Yurika</creatorcontrib><creatorcontrib>Sakai, Takayoshi</creatorcontrib><title>The efficacy of nasal airway stent (Nastent) on obstructive sleep apnoea and prediction of treatment outcomes</title><title>Journal of oral rehabilitation</title><addtitle>J Oral Rehabil</addtitle><description>Summary
Background
Obstructive sleep apnoea (OSA) is characterised by recurrent episodes of partial or complete upper airway collapse during sleep and is highly prevalent in the general population. The nasopharyngeal airway stent (Nastent) is a specifically designed, preformed silicone tube that intends to maintain the upper airway patency during sleep and reduce snoring and sleep apnoea.
Objective(s)
The purpose of this study was to determine the efficacy of Nastent treatment and examine predictors for Nastent treatment outcomes in patients with OSA.
Methods
Consecutive thirty patients were enrolled in this study. Cephalometric radiographs were obtained to analyse the pharyngeal and craniofacial morphology. Before and after Nastent treatment, we evaluated OSA using a portable sleep study.
Results
Twenty‐nine subjects completed this study. There were significant decreases in the respiratory event index (REI) (22.4 ± 14.1 to 15.7 ± 10.4, P < 0.01) and a significant increase in the lowest SpO2 (81.9 ± 7.5 to 86.6 ± 4.8, P < 0.01) by Nastent treatment. Subjects were divided into responders and non‐responders based on reduction in REI of >50% compared with baseline REI. We evaluated the ratio of inferior airway width and middle airway width (IAW/MAW) on cephalograms as the index of the narrowest airway site. The IAW/MAW was significantly higher in responders than in non‐responders (1.4 ± 0.9 vs 0.9 ± 0.4, P < 0.01) and predicted treatment responders with high accuracy (sensitivity: 90.9%, specificity: 88.9%, when IAW/MAW was set at 1.10).
Conclusions
The Nastent device improved OSA, and a narrower velopharynx than hypopharynx predicted treatment response with a good sensitivity and specificity.</description><subject>Apnea</subject><subject>Cephalometry</subject><subject>Clinical outcomes</subject><subject>Craniofacial Abnormalities - diagnostic imaging</subject><subject>Craniofacial Abnormalities - physiopathology</subject><subject>Dentistry</subject><subject>Facial Bones - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Hypopharynx</subject><subject>Implants</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nasal airway stent</subject><subject>obstructive sleep apnoea</subject><subject>Patients</subject><subject>Pharynx</subject><subject>Pharynx - diagnostic imaging</subject><subject>Pharynx - physiopathology</subject><subject>prediction</subject><subject>Radiography</subject><subject>Respiratory tract</subject><subject>Silicones</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - diagnostic imaging</subject><subject>Sleep Apnea, Obstructive - etiology</subject><subject>Sleep deprivation</subject><subject>Sleep disorders</subject><subject>Snoring</subject><subject>Stents</subject><subject>Treatment Outcome</subject><issn>0305-182X</issn><issn>1365-2842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c1q3DAUBWBRWprJz6YPEATdJAUnupLlkZchtElL6EBIIDtzR7qiHmzLkeyEefvambSLLKKNhPRxuOgw9gXEGUzrfBNCPAO5lPoDW4AqdCZNLj-yhVBCZ2Dkwx7bT2kjhDBKLz-zPSWkme7zBWvv_hAn72uLdsuD5x0mbDjW8Rm3PA3UDfzkN74cTnnoeFinIY52qJ-Ip4ao59h3gZBj53gfydXT2-w8HyLh0M4JYRxsaCkdsk8em0RHr_sBu__x_e7yOrtZXf28vLjJbK5LneXeC_DKFT5HcNIoXDpYK6eXwhROgiADyhhZWqVROyUMlE4K5SzKwhCpA3ayy-1jeBwpDVVbJ0tNgx2FMVUSoACpSyMn-vUN3YQxdtN0k9KFLFUOs_q2UzaGlCL5qo91i3FbgajmEqq5hOqlhAkfv0aO65bcf_rv1ycAO_BcN7R9J6r6tVrd7kL_Am00kcQ</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Okuno, Kentaro</creator><creator>Ono Minagi, Hitomi</creator><creator>Ikai, Kazuki</creator><creator>Matsumura Ai, Erika</creator><creator>Takai, Etsuko</creator><creator>Fukatsu, Hikari</creator><creator>Uchida, Yurika</creator><creator>Sakai, Takayoshi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1737-7958</orcidid></search><sort><creationdate>201901</creationdate><title>The efficacy of nasal airway stent (Nastent) on obstructive sleep apnoea and prediction of treatment outcomes</title><author>Okuno, Kentaro ; Ono Minagi, Hitomi ; Ikai, Kazuki ; Matsumura Ai, Erika ; Takai, Etsuko ; Fukatsu, Hikari ; Uchida, Yurika ; Sakai, Takayoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4595-4ff01f3d6f4a1d283a7d1b3d57086d210e8138829c35a5d30819d203dca268ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Apnea</topic><topic>Cephalometry</topic><topic>Clinical outcomes</topic><topic>Craniofacial Abnormalities - diagnostic imaging</topic><topic>Craniofacial Abnormalities - physiopathology</topic><topic>Dentistry</topic><topic>Facial Bones - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Hypopharynx</topic><topic>Implants</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nasal airway stent</topic><topic>obstructive sleep apnoea</topic><topic>Patients</topic><topic>Pharynx</topic><topic>Pharynx - diagnostic imaging</topic><topic>Pharynx - physiopathology</topic><topic>prediction</topic><topic>Radiography</topic><topic>Respiratory tract</topic><topic>Silicones</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - diagnostic imaging</topic><topic>Sleep Apnea, Obstructive - etiology</topic><topic>Sleep deprivation</topic><topic>Sleep disorders</topic><topic>Snoring</topic><topic>Stents</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okuno, Kentaro</creatorcontrib><creatorcontrib>Ono Minagi, Hitomi</creatorcontrib><creatorcontrib>Ikai, Kazuki</creatorcontrib><creatorcontrib>Matsumura Ai, Erika</creatorcontrib><creatorcontrib>Takai, Etsuko</creatorcontrib><creatorcontrib>Fukatsu, Hikari</creatorcontrib><creatorcontrib>Uchida, Yurika</creatorcontrib><creatorcontrib>Sakai, Takayoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okuno, Kentaro</au><au>Ono Minagi, Hitomi</au><au>Ikai, Kazuki</au><au>Matsumura Ai, Erika</au><au>Takai, Etsuko</au><au>Fukatsu, Hikari</au><au>Uchida, Yurika</au><au>Sakai, Takayoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficacy of nasal airway stent (Nastent) on obstructive sleep apnoea and prediction of treatment outcomes</atitle><jtitle>Journal of oral rehabilitation</jtitle><addtitle>J Oral Rehabil</addtitle><date>2019-01</date><risdate>2019</risdate><volume>46</volume><issue>1</issue><spage>51</spage><epage>57</epage><pages>51-57</pages><issn>0305-182X</issn><eissn>1365-2842</eissn><abstract>Summary
Background
Obstructive sleep apnoea (OSA) is characterised by recurrent episodes of partial or complete upper airway collapse during sleep and is highly prevalent in the general population. The nasopharyngeal airway stent (Nastent) is a specifically designed, preformed silicone tube that intends to maintain the upper airway patency during sleep and reduce snoring and sleep apnoea.
Objective(s)
The purpose of this study was to determine the efficacy of Nastent treatment and examine predictors for Nastent treatment outcomes in patients with OSA.
Methods
Consecutive thirty patients were enrolled in this study. Cephalometric radiographs were obtained to analyse the pharyngeal and craniofacial morphology. Before and after Nastent treatment, we evaluated OSA using a portable sleep study.
Results
Twenty‐nine subjects completed this study. There were significant decreases in the respiratory event index (REI) (22.4 ± 14.1 to 15.7 ± 10.4, P < 0.01) and a significant increase in the lowest SpO2 (81.9 ± 7.5 to 86.6 ± 4.8, P < 0.01) by Nastent treatment. Subjects were divided into responders and non‐responders based on reduction in REI of >50% compared with baseline REI. We evaluated the ratio of inferior airway width and middle airway width (IAW/MAW) on cephalograms as the index of the narrowest airway site. The IAW/MAW was significantly higher in responders than in non‐responders (1.4 ± 0.9 vs 0.9 ± 0.4, P < 0.01) and predicted treatment responders with high accuracy (sensitivity: 90.9%, specificity: 88.9%, when IAW/MAW was set at 1.10).
Conclusions
The Nastent device improved OSA, and a narrower velopharynx than hypopharynx predicted treatment response with a good sensitivity and specificity.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30281824</pmid><doi>10.1111/joor.12725</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1737-7958</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of oral rehabilitation, 2019-01, Vol.46 (1), p.51-57 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Apnea Cephalometry Clinical outcomes Craniofacial Abnormalities - diagnostic imaging Craniofacial Abnormalities - physiopathology Dentistry Facial Bones - diagnostic imaging Female Humans Hypopharynx Implants Male Middle Aged nasal airway stent obstructive sleep apnoea Patients Pharynx Pharynx - diagnostic imaging Pharynx - physiopathology prediction Radiography Respiratory tract Silicones Sleep Sleep apnea Sleep Apnea, Obstructive - diagnostic imaging Sleep Apnea, Obstructive - etiology Sleep deprivation Sleep disorders Snoring Stents Treatment Outcome |
| title | The efficacy of nasal airway stent (Nastent) on obstructive sleep apnoea and prediction of treatment outcomes |
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