Ascorbic acid inhibits visceral obesity and nonalcoholic fatty liver disease by activating peroxisome proliferator-activated receptor α in high-fat-diet-fed C57BL/6J mice

Background/objectives: Ascorbic acid is a known cofactor in the biosynthesis of carnitine, a molecule that has an obligatory role in fatty acid oxidation. Our previous studies have demonstrated that obesity is regulated effectively through peroxisome proliferator-activated receptor α (PPARα)-mediate...

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Veröffentlicht in:	International Journal of Obesity 2019-08, Vol.43 (8), p.1620-1630
Hauptverfasser:	Lee, Hyunghee, Ahn, Jiwon, Shin, Soon Shik, Yoon, Michung
Format:	Artikel
Sprache:	eng
Schlagworte:	14/63 38/39 38/77 631/443/319/1642/2037 631/443/319/1642/393 64/60 Adipose tissue Alanine Alanine transaminase Animals Apoptosis Ascorbic acid Ascorbic Acid - antagonists & inhibitors Ascorbic Acid - pharmacology Aspartate aminotransferase Biosynthesis Body weight Body weight gain Carnitine Cholesterol Diet Diet, Fat-Restricted Diet, High-Fat Dietary Supplements Epidemiology Fatty acids Fatty Acids - metabolism Fatty liver Fibrosis Food consumption Gene Expression Health Promotion and Disease Prevention High fat diet Histology Internal Medicine Intra-Abdominal Fat - drug effects Intra-Abdominal Fat - pathology Liver Liver - drug effects Liver - pathology Liver diseases Low density lipoprotein Low fat diet Male Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Mice, Obese Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Nutrient deficiency Obesity Obesity, Abdominal - genetics Obesity, Abdominal - metabolism Oxidation Oxidation-Reduction - drug effects PPAR alpha - genetics PPAR alpha - metabolism Public Health Serum levels Steatosis Vitamin C Weight Gain - drug effects Weight reduction
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