Influence of polyphenolic content on the in vitro allergenicity of old and new apple cultivars: A pilot study
•Significantly more polyphenols were found in old apple cultivars.•Significantly higher in vitro allergenicity was seen in new apple cultivars.•We demonstrated an inverse correlation of polyphenols with in vitro allergenicity.•There was a decrease of in vitro allergenicity as the degree of enzymatic...
Gespeichert in:
| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2019-02, Vol.58, p.30-35 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 35 |
|---|---|
| container_issue | |
| container_start_page | 30 |
| container_title | Nutrition (Burbank, Los Angeles County, Calif.) |
| container_volume | 58 |
| creator | Kschonsek, Josephine Wiegand, Cornelia Hipler, Uta-Christina Böhm, Volker |
| description | •Significantly more polyphenols were found in old apple cultivars.•Significantly higher in vitro allergenicity was seen in new apple cultivars.•We demonstrated an inverse correlation of polyphenols with in vitro allergenicity.•There was a decrease of in vitro allergenicity as the degree of enzymatic browning increased.
More than 70% of birch pollen–allergic individuals are affected by a cross-allergy from apples. The aim of this study was to determine if an increased polyphenolic content of apples is inversely related to clinical allergic reactions in sufferers.
The polyphenolic content of two old and two new apple cultivars was analyzed using high performance liquid chromatography. The in vitro concentration of sulfidoleukotrienes and the CD63 basophil activation of 27 birch pollen sufferers with cross-reactivity to apples were determined with cellular antigen stimulation and basophil activation tests after incubation with different apple cultivars.
The flesh of old cultivars was characterized by significantly higher total polyphenolic content (86.1 ± 5.5 µg/g) than that of new cultivars (24.7 ± 7.2 µg/g). The concentration of sulfidoleukotrienes and the CD63 basophil activation of old apple cultivars was up to 62% lower than new ones and decreased as the degree of enzymatic browning increased.
Old apples cultivars are better tolerated than new ones by birch pollen-allergic individuals. The in vitro allergenicity (activation of effector cells) of apples depends on the total polyphenolic content and the degree of enzymatic browning. |
| doi_str_mv | 10.1016/j.nut.2018.07.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2116121607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0899900718304507</els_id><sourcerecordid>2166058744</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-fc1d67ccea387cee81f94aaf1180e50f010762db223e530c01c803da23d703863</originalsourceid><addsrcrecordid>eNp9kT1vFDEURS0EIkvgB9AgSzQ0Mzzbs2MPVFHER6RINFBbjv2GeOW1B9uz0f57vNpAQUH1mnOvnu4h5DWDngEb3-_6uNaeA1M9yB6APSEbpqToGB-Gp2QDapq6CUBekBel7KAR0zg9JxcCuFQDlxuyv4lzWDFapGmmSwrH5R5jCt5Sm2LFWGmKtN4j9ZEefM2JmhAw_8Tora_HUyoFR010NOIDNcsSkNo1VH8wuXygV3TxIVVa6uqOL8mz2YSCrx7vJfnx-dP366_d7bcvN9dXt50VitVutsyN0lo0QkmLqNg8DcbMjCnALczAQI7c3XEucCvAArMKhDNcOAlCjeKSvDv3Ljn9WrFUvffFYggmYlqL5oyNjLMRZEPf_oPu0ppj-65R4whbJYehUexM2ZxKyTjrJfu9yUfNQJ9c6J1uLvTJhQap29It8-axeb3bo_ub-DN-Az6eAWxTHDxmXaw_qXA-o63aJf-f-t_kb5n0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2166058744</pqid></control><display><type>article</type><title>Influence of polyphenolic content on the in vitro allergenicity of old and new apple cultivars: A pilot study</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>ProQuest Central UK/Ireland</source><creator>Kschonsek, Josephine ; Wiegand, Cornelia ; Hipler, Uta-Christina ; Böhm, Volker</creator><creatorcontrib>Kschonsek, Josephine ; Wiegand, Cornelia ; Hipler, Uta-Christina ; Böhm, Volker</creatorcontrib><description>•Significantly more polyphenols were found in old apple cultivars.•Significantly higher in vitro allergenicity was seen in new apple cultivars.•We demonstrated an inverse correlation of polyphenols with in vitro allergenicity.•There was a decrease of in vitro allergenicity as the degree of enzymatic browning increased.
More than 70% of birch pollen–allergic individuals are affected by a cross-allergy from apples. The aim of this study was to determine if an increased polyphenolic content of apples is inversely related to clinical allergic reactions in sufferers.
The polyphenolic content of two old and two new apple cultivars was analyzed using high performance liquid chromatography. The in vitro concentration of sulfidoleukotrienes and the CD63 basophil activation of 27 birch pollen sufferers with cross-reactivity to apples were determined with cellular antigen stimulation and basophil activation tests after incubation with different apple cultivars.
The flesh of old cultivars was characterized by significantly higher total polyphenolic content (86.1 ± 5.5 µg/g) than that of new cultivars (24.7 ± 7.2 µg/g). The concentration of sulfidoleukotrienes and the CD63 basophil activation of old apple cultivars was up to 62% lower than new ones and decreased as the degree of enzymatic browning increased.
Old apples cultivars are better tolerated than new ones by birch pollen-allergic individuals. The in vitro allergenicity (activation of effector cells) of apples depends on the total polyphenolic content and the degree of enzymatic browning.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2018.07.001</identifier><identifier>PMID: 30278427</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acids ; Activation ; Adult ; Allergenicity ; Allergens - immunology ; Allergic reactions ; Allergies ; Apple polyphenols ; Apples ; BAT ; Birch pollen allergy ; CAST ; CD63 antigen ; Cross-reactivity ; Cultivars ; Dermatology ; Effector cells ; Enzymatic browning ; Enzymic browning ; Female ; Food Hypersensitivity - immunology ; Fruits ; High performance liquid chromatography ; HPLC ; Humans ; IgE ; In Vitro Techniques ; Liquid chromatography ; Mal d 1 ; Male ; Malus - immunology ; Middle Aged ; Pilot Projects ; Pollen ; Polyphenols ; Polyphenols - immunology ; Proteins ; Young Adult</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2019-02, Vol.58, p.30-35</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-fc1d67ccea387cee81f94aaf1180e50f010762db223e530c01c803da23d703863</citedby><cites>FETCH-LOGICAL-c381t-fc1d67ccea387cee81f94aaf1180e50f010762db223e530c01c803da23d703863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2166058744?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30278427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kschonsek, Josephine</creatorcontrib><creatorcontrib>Wiegand, Cornelia</creatorcontrib><creatorcontrib>Hipler, Uta-Christina</creatorcontrib><creatorcontrib>Böhm, Volker</creatorcontrib><title>Influence of polyphenolic content on the in vitro allergenicity of old and new apple cultivars: A pilot study</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>•Significantly more polyphenols were found in old apple cultivars.•Significantly higher in vitro allergenicity was seen in new apple cultivars.•We demonstrated an inverse correlation of polyphenols with in vitro allergenicity.•There was a decrease of in vitro allergenicity as the degree of enzymatic browning increased.
More than 70% of birch pollen–allergic individuals are affected by a cross-allergy from apples. The aim of this study was to determine if an increased polyphenolic content of apples is inversely related to clinical allergic reactions in sufferers.
The polyphenolic content of two old and two new apple cultivars was analyzed using high performance liquid chromatography. The in vitro concentration of sulfidoleukotrienes and the CD63 basophil activation of 27 birch pollen sufferers with cross-reactivity to apples were determined with cellular antigen stimulation and basophil activation tests after incubation with different apple cultivars.
The flesh of old cultivars was characterized by significantly higher total polyphenolic content (86.1 ± 5.5 µg/g) than that of new cultivars (24.7 ± 7.2 µg/g). The concentration of sulfidoleukotrienes and the CD63 basophil activation of old apple cultivars was up to 62% lower than new ones and decreased as the degree of enzymatic browning increased.
Old apples cultivars are better tolerated than new ones by birch pollen-allergic individuals. The in vitro allergenicity (activation of effector cells) of apples depends on the total polyphenolic content and the degree of enzymatic browning.</description><subject>Acids</subject><subject>Activation</subject><subject>Adult</subject><subject>Allergenicity</subject><subject>Allergens - immunology</subject><subject>Allergic reactions</subject><subject>Allergies</subject><subject>Apple polyphenols</subject><subject>Apples</subject><subject>BAT</subject><subject>Birch pollen allergy</subject><subject>CAST</subject><subject>CD63 antigen</subject><subject>Cross-reactivity</subject><subject>Cultivars</subject><subject>Dermatology</subject><subject>Effector cells</subject><subject>Enzymatic browning</subject><subject>Enzymic browning</subject><subject>Female</subject><subject>Food Hypersensitivity - immunology</subject><subject>Fruits</subject><subject>High performance liquid chromatography</subject><subject>HPLC</subject><subject>Humans</subject><subject>IgE</subject><subject>In Vitro Techniques</subject><subject>Liquid chromatography</subject><subject>Mal d 1</subject><subject>Male</subject><subject>Malus - immunology</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Pollen</subject><subject>Polyphenols</subject><subject>Polyphenols - immunology</subject><subject>Proteins</subject><subject>Young Adult</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kT1vFDEURS0EIkvgB9AgSzQ0Mzzbs2MPVFHER6RINFBbjv2GeOW1B9uz0f57vNpAQUH1mnOvnu4h5DWDngEb3-_6uNaeA1M9yB6APSEbpqToGB-Gp2QDapq6CUBekBel7KAR0zg9JxcCuFQDlxuyv4lzWDFapGmmSwrH5R5jCt5Sm2LFWGmKtN4j9ZEefM2JmhAw_8Tora_HUyoFR010NOIDNcsSkNo1VH8wuXygV3TxIVVa6uqOL8mz2YSCrx7vJfnx-dP366_d7bcvN9dXt50VitVutsyN0lo0QkmLqNg8DcbMjCnALczAQI7c3XEucCvAArMKhDNcOAlCjeKSvDv3Ljn9WrFUvffFYggmYlqL5oyNjLMRZEPf_oPu0ppj-65R4whbJYehUexM2ZxKyTjrJfu9yUfNQJ9c6J1uLvTJhQap29It8-axeb3bo_ub-DN-Az6eAWxTHDxmXaw_qXA-o63aJf-f-t_kb5n0</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Kschonsek, Josephine</creator><creator>Wiegand, Cornelia</creator><creator>Hipler, Uta-Christina</creator><creator>Böhm, Volker</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201902</creationdate><title>Influence of polyphenolic content on the in vitro allergenicity of old and new apple cultivars: A pilot study</title><author>Kschonsek, Josephine ; Wiegand, Cornelia ; Hipler, Uta-Christina ; Böhm, Volker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-fc1d67ccea387cee81f94aaf1180e50f010762db223e530c01c803da23d703863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acids</topic><topic>Activation</topic><topic>Adult</topic><topic>Allergenicity</topic><topic>Allergens - immunology</topic><topic>Allergic reactions</topic><topic>Allergies</topic><topic>Apple polyphenols</topic><topic>Apples</topic><topic>BAT</topic><topic>Birch pollen allergy</topic><topic>CAST</topic><topic>CD63 antigen</topic><topic>Cross-reactivity</topic><topic>Cultivars</topic><topic>Dermatology</topic><topic>Effector cells</topic><topic>Enzymatic browning</topic><topic>Enzymic browning</topic><topic>Female</topic><topic>Food Hypersensitivity - immunology</topic><topic>Fruits</topic><topic>High performance liquid chromatography</topic><topic>HPLC</topic><topic>Humans</topic><topic>IgE</topic><topic>In Vitro Techniques</topic><topic>Liquid chromatography</topic><topic>Mal d 1</topic><topic>Male</topic><topic>Malus - immunology</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Pollen</topic><topic>Polyphenols</topic><topic>Polyphenols - immunology</topic><topic>Proteins</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kschonsek, Josephine</creatorcontrib><creatorcontrib>Wiegand, Cornelia</creatorcontrib><creatorcontrib>Hipler, Uta-Christina</creatorcontrib><creatorcontrib>Böhm, Volker</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kschonsek, Josephine</au><au>Wiegand, Cornelia</au><au>Hipler, Uta-Christina</au><au>Böhm, Volker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of polyphenolic content on the in vitro allergenicity of old and new apple cultivars: A pilot study</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2019-02</date><risdate>2019</risdate><volume>58</volume><spage>30</spage><epage>35</epage><pages>30-35</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>•Significantly more polyphenols were found in old apple cultivars.•Significantly higher in vitro allergenicity was seen in new apple cultivars.•We demonstrated an inverse correlation of polyphenols with in vitro allergenicity.•There was a decrease of in vitro allergenicity as the degree of enzymatic browning increased.
More than 70% of birch pollen–allergic individuals are affected by a cross-allergy from apples. The aim of this study was to determine if an increased polyphenolic content of apples is inversely related to clinical allergic reactions in sufferers.
The polyphenolic content of two old and two new apple cultivars was analyzed using high performance liquid chromatography. The in vitro concentration of sulfidoleukotrienes and the CD63 basophil activation of 27 birch pollen sufferers with cross-reactivity to apples were determined with cellular antigen stimulation and basophil activation tests after incubation with different apple cultivars.
The flesh of old cultivars was characterized by significantly higher total polyphenolic content (86.1 ± 5.5 µg/g) than that of new cultivars (24.7 ± 7.2 µg/g). The concentration of sulfidoleukotrienes and the CD63 basophil activation of old apple cultivars was up to 62% lower than new ones and decreased as the degree of enzymatic browning increased.
Old apples cultivars are better tolerated than new ones by birch pollen-allergic individuals. The in vitro allergenicity (activation of effector cells) of apples depends on the total polyphenolic content and the degree of enzymatic browning.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30278427</pmid><doi>10.1016/j.nut.2018.07.001</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2019-02, Vol.58, p.30-35 |
| issn | 0899-9007 1873-1244 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2116121607 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Acids Activation Adult Allergenicity Allergens - immunology Allergic reactions Allergies Apple polyphenols Apples BAT Birch pollen allergy CAST CD63 antigen Cross-reactivity Cultivars Dermatology Effector cells Enzymatic browning Enzymic browning Female Food Hypersensitivity - immunology Fruits High performance liquid chromatography HPLC Humans IgE In Vitro Techniques Liquid chromatography Mal d 1 Male Malus - immunology Middle Aged Pilot Projects Pollen Polyphenols Polyphenols - immunology Proteins Young Adult |
| title | Influence of polyphenolic content on the in vitro allergenicity of old and new apple cultivars: A pilot study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T16%3A29%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20polyphenolic%20content%20on%20the%20in%20vitro%20allergenicity%20of%20old%20and%20new%20apple%20cultivars:%20A%20pilot%20study&rft.jtitle=Nutrition%20(Burbank,%20Los%20Angeles%20County,%20Calif.)&rft.au=Kschonsek,%20Josephine&rft.date=2019-02&rft.volume=58&rft.spage=30&rft.epage=35&rft.pages=30-35&rft.issn=0899-9007&rft.eissn=1873-1244&rft_id=info:doi/10.1016/j.nut.2018.07.001&rft_dat=%3Cproquest_cross%3E2166058744%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2166058744&rft_id=info:pmid/30278427&rft_els_id=S0899900718304507&rfr_iscdi=true |