A Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b

Although conjugation with polyethylene glycol (PEGylation) improves the pharmacokinetics of therapeutic proteins, it drastically decreases their bioactivity. Site-specific PEGylation counters the reduction in bioactivity, but developing PEGylated proteins with equivalent bioactivity to that of their...

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Veröffentlicht in:	ACS synthetic biology 2018-11, Vol.7 (11), p.2537-2546
Hauptverfasser:	Imada, Takashi, Moriya, Koji, Uchiyama, Masahiko, Inukai, Naoto, Hitotsuyanagi, Mitsuhiro, Masuda, Akiko, Suzuki, Takehiro, Ayukawa, Shotaro, Tagawa, Yo-ichi, Dohmae, Naoshi, Kohara, Michinori, Yamamura, Masayuki, Kiga, Daisuke
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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