Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability-High Colorectal Cancers

Colorectal cancers with microsatellite instability-high (MSI-H) status, due to mismatch repair deficiency, are associated with poor patient outcomes after relapse. We aimed to identify novel therapeutic targets for them. We performed MSI analyses of over 2,800 surgically resected colorectal tumors o...

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Veröffentlicht in:	Clinical cancer research 2019-01, Vol.25 (1), p.378-389
Hauptverfasser:	Sato, Kazuhito, Kawazu, Masahito, Yamamoto, Yoko, Ueno, Toshihide, Kojima, Shinya, Nagae, Genta, Abe, Hiroyuki, Soda, Manabu, Oga, Takafumi, Kohsaka, Shinji, Sai, Eirin, Yamashita, Yoshihiro, Iinuma, Hisae, Fukayama, Masashi, Aburatani, Hiroyuki, Watanabe, Toshiaki, Mano, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers, Tumor Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Disease-Free Survival DNA Methylation - genetics DNA Mismatch Repair - genetics Female Genetic Markers Genomics Germ-Line Mutation - genetics Humans Japan - epidemiology Male Microsatellite Instability Microsatellite Repeats Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Promoter Regions, Genetic Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Ubiquitin-Protein Ligases - genetics
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