Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats
Painful peripheral neuropathy can be associated with nerve damage caused by diabetes mellitus. Although pregabalin is the first‐line therapy for peripheral neuropathy, it shows substantial discontinuation rates, mainly because of nervous system side effects as motor incoordination. Multimodal therap...
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| Veröffentlicht in: | Drug development research 2018-11, Vol.79 (7), p.362-369 |
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| creator | Cruz‐Álvarez, Lidia Elizabeth de la Zúñiga‐Romero, Ángel Huerta‐Cruz, Juan Carlos Flores‐Murrieta, Francisco Javier Reyes‐García, Juan Gerardo Araiza‐Saldaña, Claudia Ivonne Rocha‐González, Héctor Isaac |
| description | Painful peripheral neuropathy can be associated with nerve damage caused by diabetes mellitus. Although pregabalin is the first‐line therapy for peripheral neuropathy, it shows substantial discontinuation rates, mainly because of nervous system side effects as motor incoordination. Multimodal therapy may improve the motor side effect profile of pregabalin. The aim of this study was to evaluate the interaction of pregabalin + thioctic acid or pregabalin + α‐tocopherol on allodynia and motor performance in neonatal streptozotocin‐induced diabetic rats. Efficacy of drugs separately or in combination was tested by tactile allodynia using von Frey filaments. Isobolographic and interaction index analysis were used to determine the antiallodynic interaction between pregabalin and either thioctic acid or α‐tocopherol. Motor performance was measured using a rotarod test. Pregabalin, thioctic acid, and α‐tocopherol reduced, in a dose‐dependent fashion, tactile allodynia. Pregabalin + thioctic acid and pregabalin + α‐tocopherol combinations also dose‐dependently reduced allodynic behavior in diabetic rats. Isobolographic analysis revealed an additive interaction for both combinations. Consistently, the interaction indices confirmed the additive effect between pregabalin + thioctic acid and pregabalin + α‐tocopherol. In addition, the administration of either combination improved motor incoordination induced by pregabalin. Data suggests that thioctic acid or α‐tocopherol could positively impact the therapeutic profile of pregabalin, because they might be useful for reducing motor incoordination associated to pregabalin in patients with peripheral neuropathy. |
| doi_str_mv | 10.1002/ddr.21473 |
| format | Article |
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Although pregabalin is the first‐line therapy for peripheral neuropathy, it shows substantial discontinuation rates, mainly because of nervous system side effects as motor incoordination. Multimodal therapy may improve the motor side effect profile of pregabalin. The aim of this study was to evaluate the interaction of pregabalin + thioctic acid or pregabalin + α‐tocopherol on allodynia and motor performance in neonatal streptozotocin‐induced diabetic rats. Efficacy of drugs separately or in combination was tested by tactile allodynia using von Frey filaments. Isobolographic and interaction index analysis were used to determine the antiallodynic interaction between pregabalin and either thioctic acid or α‐tocopherol. Motor performance was measured using a rotarod test. Pregabalin, thioctic acid, and α‐tocopherol reduced, in a dose‐dependent fashion, tactile allodynia. Pregabalin + thioctic acid and pregabalin + α‐tocopherol combinations also dose‐dependently reduced allodynic behavior in diabetic rats. Isobolographic analysis revealed an additive interaction for both combinations. Consistently, the interaction indices confirmed the additive effect between pregabalin + thioctic acid and pregabalin + α‐tocopherol. In addition, the administration of either combination improved motor incoordination induced by pregabalin. Data suggests that thioctic acid or α‐tocopherol could positively impact the therapeutic profile of pregabalin, because they might be useful for reducing motor incoordination associated to pregabalin in patients with peripheral neuropathy.</description><identifier>ISSN: 0272-4391</identifier><identifier>EISSN: 1098-2299</identifier><identifier>DOI: 10.1002/ddr.21473</identifier><identifier>PMID: 30276837</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Acids ; allodynia, diabetes, isobologram, motor performance, pregabalin, thioctic acid ; alpha-Tocopherol - administration & dosage ; Analgesics - administration & dosage ; Animals ; Animals, Newborn ; Antioxidants - administration & dosage ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - physiopathology ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Filaments ; Hyperalgesia - drug therapy ; Hyperalgesia - physiopathology ; Lipoic acid ; Motor task performance ; Motors ; Neonates ; Nervous system ; Pain perception ; Peripheral neuropathy ; Pregabalin - administration & dosage ; Psychomotor Performance - drug effects ; Psychomotor Performance - physiology ; Rats ; Rats, Wistar ; Rodents ; Side effects ; Streptozocin ; Tactile ; Tactile stimuli ; Therapy ; Thioctic Acid - administration & dosage ; Tocopherol ; Vitamin E ; α‐tocopherol</subject><ispartof>Drug development research, 2018-11, Vol.79 (7), p.362-369</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-f347652bf5296c8de3f5e9a9f88b6748ea55f54156c6dfe9c70d0835e5d205513</citedby><cites>FETCH-LOGICAL-c3533-f347652bf5296c8de3f5e9a9f88b6748ea55f54156c6dfe9c70d0835e5d205513</cites><orcidid>0000-0002-3199-5683 ; 0000-0002-7524-9375</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fddr.21473$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fddr.21473$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30276837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruz‐Álvarez, Lidia Elizabeth de la</creatorcontrib><creatorcontrib>Zúñiga‐Romero, Ángel</creatorcontrib><creatorcontrib>Huerta‐Cruz, Juan Carlos</creatorcontrib><creatorcontrib>Flores‐Murrieta, Francisco Javier</creatorcontrib><creatorcontrib>Reyes‐García, Juan Gerardo</creatorcontrib><creatorcontrib>Araiza‐Saldaña, Claudia Ivonne</creatorcontrib><creatorcontrib>Rocha‐González, Héctor Isaac</creatorcontrib><title>Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats</title><title>Drug development research</title><addtitle>Drug Dev Res</addtitle><description>Painful peripheral neuropathy can be associated with nerve damage caused by diabetes mellitus. Although pregabalin is the first‐line therapy for peripheral neuropathy, it shows substantial discontinuation rates, mainly because of nervous system side effects as motor incoordination. Multimodal therapy may improve the motor side effect profile of pregabalin. The aim of this study was to evaluate the interaction of pregabalin + thioctic acid or pregabalin + α‐tocopherol on allodynia and motor performance in neonatal streptozotocin‐induced diabetic rats. Efficacy of drugs separately or in combination was tested by tactile allodynia using von Frey filaments. Isobolographic and interaction index analysis were used to determine the antiallodynic interaction between pregabalin and either thioctic acid or α‐tocopherol. Motor performance was measured using a rotarod test. Pregabalin, thioctic acid, and α‐tocopherol reduced, in a dose‐dependent fashion, tactile allodynia. Pregabalin + thioctic acid and pregabalin + α‐tocopherol combinations also dose‐dependently reduced allodynic behavior in diabetic rats. Isobolographic analysis revealed an additive interaction for both combinations. Consistently, the interaction indices confirmed the additive effect between pregabalin + thioctic acid and pregabalin + α‐tocopherol. In addition, the administration of either combination improved motor incoordination induced by pregabalin. Data suggests that thioctic acid or α‐tocopherol could positively impact the therapeutic profile of pregabalin, because they might be useful for reducing motor incoordination associated to pregabalin in patients with peripheral neuropathy.</description><subject>Acids</subject><subject>allodynia, diabetes, isobologram, motor performance, pregabalin, thioctic acid</subject><subject>alpha-Tocopherol - administration & dosage</subject><subject>Analgesics - administration & dosage</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antioxidants - administration & dosage</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Therapy, Combination</subject><subject>Filaments</subject><subject>Hyperalgesia - drug therapy</subject><subject>Hyperalgesia - physiopathology</subject><subject>Lipoic acid</subject><subject>Motor task performance</subject><subject>Motors</subject><subject>Neonates</subject><subject>Nervous system</subject><subject>Pain perception</subject><subject>Peripheral neuropathy</subject><subject>Pregabalin - administration & dosage</subject><subject>Psychomotor Performance - drug effects</subject><subject>Psychomotor Performance - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Side effects</subject><subject>Streptozocin</subject><subject>Tactile</subject><subject>Tactile stimuli</subject><subject>Therapy</subject><subject>Thioctic Acid - administration & dosage</subject><subject>Tocopherol</subject><subject>Vitamin E</subject><subject>α‐tocopherol</subject><issn>0272-4391</issn><issn>1098-2299</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd1qFTEUhYNY7LF64QtIwBu9mJ78TDIzl6X1DwqFotdDJtnxpMwkY5KhHK_6CH0SwRfxIXwSc3qqSMGrzWZ_a60NC6EXlBxTQtjamHjMaN3wR2hFSddWjHXdY7QirGFVzTt6iJ6mdEUIpXXbPkGHvFxky5sV-n7is1PjGMzWO42dzxCVzi54rLzBU8gh4hmiDXFSXgMOFucN4DnCFzWo0fl13rhQFBor7cyd6p_jzx-_bm5z0GHeQAwj1mEanFe7gFTSsIdQNjXilCPMOXwrgdr5InLeLBoMNk4NsLOPKqdn6MCqMcHz-3mEPr97--n0Q3V-8f7j6cl5pbngvLK8bqRggxWsk7o1wK2ATnW2bQfZ1C0oIayoqZBaGgudboghLRcgDCNCUH6EXu995xi-LpByP7mkYRxVeXhJPaNUNEKSmhX01QP0KizRl-8KxSljRNayUG_2lI4hpQi2n6ObVNz2lPS7EvtSYn9XYmFf3jsuwwTmL_mntQKs98C1G2H7f6f-7Oxyb_kbDtCs3Q</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Cruz‐Álvarez, Lidia Elizabeth de la</creator><creator>Zúñiga‐Romero, Ángel</creator><creator>Huerta‐Cruz, Juan Carlos</creator><creator>Flores‐Murrieta, Francisco Javier</creator><creator>Reyes‐García, Juan Gerardo</creator><creator>Araiza‐Saldaña, Claudia Ivonne</creator><creator>Rocha‐González, Héctor Isaac</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3199-5683</orcidid><orcidid>https://orcid.org/0000-0002-7524-9375</orcidid></search><sort><creationdate>201811</creationdate><title>Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats</title><author>Cruz‐Álvarez, Lidia Elizabeth de la ; Zúñiga‐Romero, Ángel ; Huerta‐Cruz, Juan Carlos ; Flores‐Murrieta, Francisco Javier ; Reyes‐García, Juan Gerardo ; Araiza‐Saldaña, Claudia Ivonne ; Rocha‐González, Héctor Isaac</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-f347652bf5296c8de3f5e9a9f88b6748ea55f54156c6dfe9c70d0835e5d205513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acids</topic><topic>allodynia, diabetes, isobologram, motor performance, pregabalin, thioctic acid</topic><topic>alpha-Tocopherol - administration & dosage</topic><topic>Analgesics - administration & dosage</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antioxidants - administration & dosage</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Therapy, Combination</topic><topic>Filaments</topic><topic>Hyperalgesia - drug therapy</topic><topic>Hyperalgesia - physiopathology</topic><topic>Lipoic acid</topic><topic>Motor task performance</topic><topic>Motors</topic><topic>Neonates</topic><topic>Nervous system</topic><topic>Pain perception</topic><topic>Peripheral neuropathy</topic><topic>Pregabalin - administration & dosage</topic><topic>Psychomotor Performance - drug effects</topic><topic>Psychomotor Performance - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Side effects</topic><topic>Streptozocin</topic><topic>Tactile</topic><topic>Tactile stimuli</topic><topic>Therapy</topic><topic>Thioctic Acid - administration & dosage</topic><topic>Tocopherol</topic><topic>Vitamin E</topic><topic>α‐tocopherol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruz‐Álvarez, Lidia Elizabeth de la</creatorcontrib><creatorcontrib>Zúñiga‐Romero, Ángel</creatorcontrib><creatorcontrib>Huerta‐Cruz, Juan Carlos</creatorcontrib><creatorcontrib>Flores‐Murrieta, Francisco Javier</creatorcontrib><creatorcontrib>Reyes‐García, Juan Gerardo</creatorcontrib><creatorcontrib>Araiza‐Saldaña, Claudia Ivonne</creatorcontrib><creatorcontrib>Rocha‐González, Héctor Isaac</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cruz‐Álvarez, Lidia Elizabeth de la</au><au>Zúñiga‐Romero, Ángel</au><au>Huerta‐Cruz, Juan Carlos</au><au>Flores‐Murrieta, Francisco Javier</au><au>Reyes‐García, Juan Gerardo</au><au>Araiza‐Saldaña, Claudia Ivonne</au><au>Rocha‐González, Héctor Isaac</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats</atitle><jtitle>Drug development research</jtitle><addtitle>Drug Dev Res</addtitle><date>2018-11</date><risdate>2018</risdate><volume>79</volume><issue>7</issue><spage>362</spage><epage>369</epage><pages>362-369</pages><issn>0272-4391</issn><eissn>1098-2299</eissn><abstract>Painful peripheral neuropathy can be associated with nerve damage caused by diabetes mellitus. Although pregabalin is the first‐line therapy for peripheral neuropathy, it shows substantial discontinuation rates, mainly because of nervous system side effects as motor incoordination. Multimodal therapy may improve the motor side effect profile of pregabalin. The aim of this study was to evaluate the interaction of pregabalin + thioctic acid or pregabalin + α‐tocopherol on allodynia and motor performance in neonatal streptozotocin‐induced diabetic rats. Efficacy of drugs separately or in combination was tested by tactile allodynia using von Frey filaments. Isobolographic and interaction index analysis were used to determine the antiallodynic interaction between pregabalin and either thioctic acid or α‐tocopherol. Motor performance was measured using a rotarod test. Pregabalin, thioctic acid, and α‐tocopherol reduced, in a dose‐dependent fashion, tactile allodynia. Pregabalin + thioctic acid and pregabalin + α‐tocopherol combinations also dose‐dependently reduced allodynic behavior in diabetic rats. Isobolographic analysis revealed an additive interaction for both combinations. Consistently, the interaction indices confirmed the additive effect between pregabalin + thioctic acid and pregabalin + α‐tocopherol. In addition, the administration of either combination improved motor incoordination induced by pregabalin. Data suggests that thioctic acid or α‐tocopherol could positively impact the therapeutic profile of pregabalin, because they might be useful for reducing motor incoordination associated to pregabalin in patients with peripheral neuropathy.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30276837</pmid><doi>10.1002/ddr.21473</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3199-5683</orcidid><orcidid>https://orcid.org/0000-0002-7524-9375</orcidid></addata></record> |
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| subjects | Acids allodynia, diabetes, isobologram, motor performance, pregabalin, thioctic acid alpha-Tocopherol - administration & dosage Analgesics - administration & dosage Animals Animals, Newborn Antioxidants - administration & dosage Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - physiopathology Dose-Response Relationship, Drug Drug Therapy, Combination Filaments Hyperalgesia - drug therapy Hyperalgesia - physiopathology Lipoic acid Motor task performance Motors Neonates Nervous system Pain perception Peripheral neuropathy Pregabalin - administration & dosage Psychomotor Performance - drug effects Psychomotor Performance - physiology Rats Rats, Wistar Rodents Side effects Streptozocin Tactile Tactile stimuli Therapy Thioctic Acid - administration & dosage Tocopherol Vitamin E α‐tocopherol |
| title | Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats |
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