Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with stable coronary artery disease (CAD) is still unclear. We enrolled 500 patients undergoing elective percutaneous coronary intervention (PCI). Blood samples were drawn prior to PCI for...
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| Veröffentlicht in: | Journal of cardiovascular translational research 2018-12, Vol.11 (6), p.517-523 |
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| creator | Bressi, Edoardo Mangiacapra, Fabio Ricottini, Elisabetta Cavallari, Ilaria Colaiori, Iginio Di Gioia, Giuseppe Creta, Antonio Capuano, Marialessia Viscusi, Michele Mattia Di Sciascio, Germano |
| description | The prognostic role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with stable coronary artery disease (CAD) is still unclear. We enrolled 500 patients undergoing elective percutaneous coronary intervention (PCI). Blood samples were drawn prior to PCI for NLR and PLR calculation. Major adverse clinical events (MACE), which included death, myocardial infarction (MI), and target vessel revascularization (TVR), were recorded up to 5 years. Patients in the higher tertile of NLR presented higher Kaplan–Meier estimates of MACE (26.0% vs. 16.9% in tertile 2 vs. 14.3% in tertile 1;
p
= 0.042) and death (12.0% vs 6.9% in tertile 2 vs. 4.6% in tertile 1;
p
= 0.040), whereas there were no significant differences in the estimates of MI and TVR. NLR in the higher tertile was an independent predictor of MACE (HR 1.65, 95% CI 1.07–2.55,
p
= 0.024). No significant difference was observed across tertiles of PLR. Unlike PLR, elevated pre-procedural NLR is associated with an increased risk of 5-year clinical adverse events. |
| doi_str_mv | 10.1007/s12265-018-9829-6 |
| format | Article |
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p
= 0.042) and death (12.0% vs 6.9% in tertile 2 vs. 4.6% in tertile 1;
p
= 0.040), whereas there were no significant differences in the estimates of MI and TVR. NLR in the higher tertile was an independent predictor of MACE (HR 1.65, 95% CI 1.07–2.55,
p
= 0.024). No significant difference was observed across tertiles of PLR. Unlike PLR, elevated pre-procedural NLR is associated with an increased risk of 5-year clinical adverse events.</description><identifier>ISSN: 1937-5387</identifier><identifier>EISSN: 1937-5395</identifier><identifier>DOI: 10.1007/s12265-018-9829-6</identifier><identifier>PMID: 30276618</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Biomarkers - blood ; Biomedical Engineering and Bioengineering ; Biomedicine ; Cardiology ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - mortality ; Coronary Artery Disease - surgery ; Female ; Human Genetics ; Humans ; Lymphocyte Count ; Lymphocytes ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neutrophils ; Original Article ; Percutaneous Coronary Intervention - adverse effects ; Percutaneous Coronary Intervention - mortality ; Predictive Value of Tests ; Prospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome</subject><ispartof>Journal of cardiovascular translational research, 2018-12, Vol.11 (6), p.517-523</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-8b17f4f9cae576f1eb77e1432d035a9323c9d5d24e5c5da790b960dc751035c03</citedby><cites>FETCH-LOGICAL-c344t-8b17f4f9cae576f1eb77e1432d035a9323c9d5d24e5c5da790b960dc751035c03</cites><orcidid>0000-0002-3505-0716</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12265-018-9829-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12265-018-9829-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30276618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bressi, Edoardo</creatorcontrib><creatorcontrib>Mangiacapra, Fabio</creatorcontrib><creatorcontrib>Ricottini, Elisabetta</creatorcontrib><creatorcontrib>Cavallari, Ilaria</creatorcontrib><creatorcontrib>Colaiori, Iginio</creatorcontrib><creatorcontrib>Di Gioia, Giuseppe</creatorcontrib><creatorcontrib>Creta, Antonio</creatorcontrib><creatorcontrib>Capuano, Marialessia</creatorcontrib><creatorcontrib>Viscusi, Michele Mattia</creatorcontrib><creatorcontrib>Di Sciascio, Germano</creatorcontrib><title>Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention</title><title>Journal of cardiovascular translational research</title><addtitle>J. of Cardiovasc. Trans. Res</addtitle><addtitle>J Cardiovasc Transl Res</addtitle><description>The prognostic role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with stable coronary artery disease (CAD) is still unclear. We enrolled 500 patients undergoing elective percutaneous coronary intervention (PCI). Blood samples were drawn prior to PCI for NLR and PLR calculation. Major adverse clinical events (MACE), which included death, myocardial infarction (MI), and target vessel revascularization (TVR), were recorded up to 5 years. Patients in the higher tertile of NLR presented higher Kaplan–Meier estimates of MACE (26.0% vs. 16.9% in tertile 2 vs. 14.3% in tertile 1;
p
= 0.042) and death (12.0% vs 6.9% in tertile 2 vs. 4.6% in tertile 1;
p
= 0.040), whereas there were no significant differences in the estimates of MI and TVR. NLR in the higher tertile was an independent predictor of MACE (HR 1.65, 95% CI 1.07–2.55,
p
= 0.024). No significant difference was observed across tertiles of PLR. Unlike PLR, elevated pre-procedural NLR is associated with an increased risk of 5-year clinical adverse events.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Cardiology</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary Artery Disease - surgery</subject><subject>Female</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Original Article</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Percutaneous Coronary Intervention - mortality</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1937-5387</issn><issn>1937-5395</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURSMEoqXwAWyQl2wMthPH8bIaWhhpREdAF6wsj_My48qxg-0UzT_yUXiUUjaI1bPkc6_e06mq15S8o4SI94ky1nJMaIdlxyRun1TnVNYC81ryp4_vTpxVL1K6I6RlRIjn1VlNmGhb2p1Xv9bjpE1GYUCfYc4xTAfrcA54cxynQzDHDOiLzjYg7Xu0dTqDg_xPIHjE8XfQEa2c9dZoh27mbMII6VS_LRD4nNBPmw_oa9Y7B2gVYvA6HtFlzFDGB5tAJ0C3voe4D9bv0ZUDk-09oC1EM2ftIczpb3DtS_C-FNvgX1bPBu0SvHqYF9Xt9dW31Se8ufm4Xl1usKmbJuNuR8XQDNJo4KIdKOyEANrUrCc117JmtZE971kD3PBeC0l2siW9EZwWwJD6onq79E4x_JghZTXaZMC5ZTnFKOWCk07KgtIFNTGkFGFQU7RjWVxRok4S1SJRFYnqJFG1JfPmoX7ejdA_Jv5YKwBbgFS-_B6iugtz9OXk_7T-BgNTrGI</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Bressi, Edoardo</creator><creator>Mangiacapra, Fabio</creator><creator>Ricottini, Elisabetta</creator><creator>Cavallari, Ilaria</creator><creator>Colaiori, Iginio</creator><creator>Di Gioia, Giuseppe</creator><creator>Creta, Antonio</creator><creator>Capuano, Marialessia</creator><creator>Viscusi, Michele Mattia</creator><creator>Di Sciascio, Germano</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3505-0716</orcidid></search><sort><creationdate>20181201</creationdate><title>Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention</title><author>Bressi, Edoardo ; Mangiacapra, Fabio ; Ricottini, Elisabetta ; Cavallari, Ilaria ; Colaiori, Iginio ; Di Gioia, Giuseppe ; Creta, Antonio ; Capuano, Marialessia ; Viscusi, Michele Mattia ; Di Sciascio, Germano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-8b17f4f9cae576f1eb77e1432d035a9323c9d5d24e5c5da790b960dc751035c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Cardiology</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary Artery Disease - surgery</topic><topic>Female</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Original Article</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Percutaneous Coronary Intervention - mortality</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bressi, Edoardo</creatorcontrib><creatorcontrib>Mangiacapra, Fabio</creatorcontrib><creatorcontrib>Ricottini, Elisabetta</creatorcontrib><creatorcontrib>Cavallari, Ilaria</creatorcontrib><creatorcontrib>Colaiori, Iginio</creatorcontrib><creatorcontrib>Di Gioia, Giuseppe</creatorcontrib><creatorcontrib>Creta, Antonio</creatorcontrib><creatorcontrib>Capuano, Marialessia</creatorcontrib><creatorcontrib>Viscusi, Michele Mattia</creatorcontrib><creatorcontrib>Di Sciascio, Germano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular translational research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bressi, Edoardo</au><au>Mangiacapra, Fabio</au><au>Ricottini, Elisabetta</au><au>Cavallari, Ilaria</au><au>Colaiori, Iginio</au><au>Di Gioia, Giuseppe</au><au>Creta, Antonio</au><au>Capuano, Marialessia</au><au>Viscusi, Michele Mattia</au><au>Di Sciascio, Germano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention</atitle><jtitle>Journal of cardiovascular translational research</jtitle><stitle>J. of Cardiovasc. Trans. Res</stitle><addtitle>J Cardiovasc Transl Res</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>11</volume><issue>6</issue><spage>517</spage><epage>523</epage><pages>517-523</pages><issn>1937-5387</issn><eissn>1937-5395</eissn><abstract>The prognostic role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with stable coronary artery disease (CAD) is still unclear. We enrolled 500 patients undergoing elective percutaneous coronary intervention (PCI). Blood samples were drawn prior to PCI for NLR and PLR calculation. Major adverse clinical events (MACE), which included death, myocardial infarction (MI), and target vessel revascularization (TVR), were recorded up to 5 years. Patients in the higher tertile of NLR presented higher Kaplan–Meier estimates of MACE (26.0% vs. 16.9% in tertile 2 vs. 14.3% in tertile 1;
p
= 0.042) and death (12.0% vs 6.9% in tertile 2 vs. 4.6% in tertile 1;
p
= 0.040), whereas there were no significant differences in the estimates of MI and TVR. NLR in the higher tertile was an independent predictor of MACE (HR 1.65, 95% CI 1.07–2.55,
p
= 0.024). No significant difference was observed across tertiles of PLR. Unlike PLR, elevated pre-procedural NLR is associated with an increased risk of 5-year clinical adverse events.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30276618</pmid><doi>10.1007/s12265-018-9829-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3505-0716</orcidid></addata></record> |
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| subjects | Aged Biomarkers - blood Biomedical Engineering and Bioengineering Biomedicine Cardiology Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - mortality Coronary Artery Disease - surgery Female Human Genetics Humans Lymphocyte Count Lymphocytes Male Medicine Medicine & Public Health Middle Aged Neutrophils Original Article Percutaneous Coronary Intervention - adverse effects Percutaneous Coronary Intervention - mortality Predictive Value of Tests Prospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome |
| title | Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention |
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