Investigation of Survivin Gene Polymorphism and Serum Survivin Levels in Patients with Brain Tumors

The single nucleotide polymorphism -31C/G identified in the survivin gene promoter seems to be associated with over-expression of survivin, an anti-apoptotic protein. In gliomas, increased survivin expression correlated with decreased survival. The aim of the study was to investigate whether survivi...

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Veröffentlicht in:	Anticancer research 2018-10, Vol.38 (10), p.5991-5998
Hauptverfasser:	Kafadar, Didem, Yaylim, Ilhan, Kafadar, Ali Metin, Cacina, Canan, Ergen, Arzu, Kaynar, Mehmet Yasar, Isbir, Turgay
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Benign Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Brain Brain cancer Brain Neoplasms - blood Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumors Case-Control Studies Enzyme-linked immunosorbent assay Female Follow-Up Studies Gene expression Gene polymorphism Genetic Predisposition to Disease Glioma Humans Inhibitor of Apoptosis Proteins - blood Inhibitor of Apoptosis Proteins - genetics Male Middle Aged Overexpression Patients Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide Prognosis Proteins Restriction fragment length polymorphism Serum levels Single-nucleotide polymorphism Survivin Tumors
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