Autophagic Gene Polymorphisms in Liquid Biopsies and Outcome of Patients with Metastatic Clear Cell Renal Cell Carcinoma

Autophagy has been shown to be involved in cancer development and response to cancer therapy. In this study, genotypes of autophagic genes were analyzed to assess their correlation with the risk of clear cell renal cell carcinoma (ccRCC) and the outcome of patients treated with pazopanib for metasta...

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Veröffentlicht in:	Anticancer research 2018-10, Vol.38 (10), p.5773-5782
Hauptverfasser:	Santoni, Matteo, Piva, Francesco, De Giorgi, Ugo, Mosca, Alessandra, Basso, Umberto, Santini, Daniele, Buti, Sebastiano, Lolli, Cristian, Terrone, Carlo, Maruzzo, Marco, Iuliani, Michele, Bersanelli, Melissa, Conti, Alessandro, Mazzucchelli, Roberta, Montironi, Rodolfo, Burattini, Luciano, Berardi, Rossana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Inhibitors - therapeutic use Autophagy Autophagy-Related Proteins - genetics Biomarkers, Tumor - genetics Cancer Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - secondary Clear cell-type renal cell carcinoma Correlation analysis Female Follow-Up Studies Genes Genotypes Humans Kidney cancer Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics Kidney Neoplasms - mortality Kidney Neoplasms - pathology Liquid Biopsy Male Metastases Metastasis Middle Aged Neoplasm Invasiveness Neoplasm Metastasis Patients Phagocytosis Polymorphism, Genetic Prognosis Pyrimidines - therapeutic use Rank tests Retrospective Studies Single-nucleotide polymorphism Sulfonamides - therapeutic use Survival Rate
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