Nondopaminergic mechanisms in levodopa-induced dyskinesia

It has become increasingly apparent that Parkinson's disease involves many transmitter systems other than dopamine. This nondopaminergic involvement impacts on the generation of symptoms, on the neurodegenerative process, but, most tellingly, in the generation of side effects of current treatme...

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Veröffentlicht in:	Movement disorders 2005-08, Vol.20 (8), p.919-931
1. Verfasser:	Brotchie, Jonathan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiparkinson Agents - adverse effects basal ganglia circuitry Biogenic Monoamines - classification Biogenic Monoamines - metabolism Biological and medical sciences Brain - cytology Brain - drug effects Brain - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Dopamine - metabolism Drug toxicity and drugs side effects treatment Dyskinesia, Drug-Induced - metabolism Dyskinesia, Drug-Induced - physiopathology globus pallidus Humans Levodopa - adverse effects levodopa-induced dyskinesia Medical sciences Neurology Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - physiopathology Pharmacology. Drug treatments postsynaptic signaling subthalamic nucleus Synaptic Transmission - physiology Toxicity: nervous system and muscle
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