Ox40 regulates the conversion and suppressive function of double-negative regulatory T cells

Naïve CD4 T cells can be converted to double-negative regulatory T cells (DNT) by mature dendritic cells (mDCs) and IL-2 stimulation, with IL-2 enhancing the proliferation and Perforin expression of DNT. However, the molecules that affect the conversion of DNT are still not clear. Here, we investiga...

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Veröffentlicht in:	International immunopharmacology 2018-12, Vol.65, p.16-22
Hauptverfasser:	Liu, Kai, Ye, Huichu, Zhou, Jin, Tian, Yue, Xu, Hufeng, Sun, Xuelian, Zhang, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Apoptosis Apoptosis - physiology CD160 CD30 CD30 antigen CD4 antigen Cell growth Cell Proliferation Conversion CXCR3 CXCR3 protein Dendritic cells Double negative T cells Down-regulation FasL protein Gene Expression Regulation - drug effects Granzyme B Immunoregulation Interleukin 2 Lymphocytes Lymphocytes T Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred Strains Mice, Knockout Ox40 Perforin T cell receptors T-Lymphocytes, Regulatory - classification T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism Tumor Necrosis Factors - genetics Tumor Necrosis Factors - metabolism
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