Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives
The reaction of thiophene-2-carbonyl isothiocyanate 2 with thioglycolic acid gave 2-(thiophene-2-carbonylcarbamothioylthio)acetic acid 3. Compound 3 was subjected to some selected reactions with sulphuric acid as well as benzaldehyde, piperonal and isatin under different reaction conditions. The pro...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2018/10/01, Vol.66(10), pp.992-998 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | El-Mawgoud, Heba Kamal Abd Atta-Allah, Saad Ramadan Hemdan, Magdy Mohamed |
| description | The reaction of thiophene-2-carbonyl isothiocyanate 2 with thioglycolic acid gave 2-(thiophene-2-carbonylcarbamothioylthio)acetic acid 3. Compound 3 was subjected to some selected reactions with sulphuric acid as well as benzaldehyde, piperonal and isatin under different reaction conditions. The products obtained were new derivatives of thiazole and annulated thiazole derivatives bearing thiophene moiety in some cases. The structures of the new synthesized compounds were confirmed on the basis of their microanalytical and spectral properties. Some compounds were tested for their antimicrobial activity against six selected microorganisms using the standard antibacterial Gentamycin and antifungal Ketoconazole as references. |
| doi_str_mv | 10.1248/cpb.c18-00482 |
| format | Article |
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Compound 3 was subjected to some selected reactions with sulphuric acid as well as benzaldehyde, piperonal and isatin under different reaction conditions. The products obtained were new derivatives of thiazole and annulated thiazole derivatives bearing thiophene moiety in some cases. The structures of the new synthesized compounds were confirmed on the basis of their microanalytical and spectral properties. Some compounds were tested for their antimicrobial activity against six selected microorganisms using the standard antibacterial Gentamycin and antifungal Ketoconazole as references.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.c18-00482</identifier><identifier>PMID: 30270245</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Acetic acid ; Acids ; Antifungal agents ; Antimicrobial activity ; Antimicrobial agents ; Benzaldehyde ; Carbonyls ; Derivatives ; Fungicides ; fused thiazole ; Gentamicin ; indole ; Isothiocyanate ; Ketoconazole ; Microorganisms ; Molecular Structure ; Piperonal ; Sulfuric acid ; thiazole ; Thiazoles - chemical synthesis ; Thiazoles - chemistry ; Thioglycolic acid ; thiophene-2-carbonyl isothiocyanate ; Thiophenes - chemistry</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2018/10/01, Vol.66(10), pp.992-998</ispartof><rights>2018 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-2c51d10315471f1b953b75dd042f9d252d1d1ccd1fabd6eb4825e6961256c5473</citedby><cites>FETCH-LOGICAL-c659t-2c51d10315471f1b953b75dd042f9d252d1d1ccd1fabd6eb4825e6961256c5473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30270245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Mawgoud, Heba Kamal Abd</creatorcontrib><creatorcontrib>Atta-Allah, Saad Ramadan</creatorcontrib><creatorcontrib>Hemdan, Magdy Mohamed</creatorcontrib><creatorcontrib>Science and Education</creatorcontrib><creatorcontrib>aDepartment of Chemistry</creatorcontrib><creatorcontrib>bDepartment of Chemistry</creatorcontrib><creatorcontrib>Faculty of Science</creatorcontrib><creatorcontrib>Faculty of Women for Arts</creatorcontrib><creatorcontrib>Ain Shams University</creatorcontrib><title>Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>The reaction of thiophene-2-carbonyl isothiocyanate 2 with thioglycolic acid gave 2-(thiophene-2-carbonylcarbamothioylthio)acetic acid 3. Compound 3 was subjected to some selected reactions with sulphuric acid as well as benzaldehyde, piperonal and isatin under different reaction conditions. The products obtained were new derivatives of thiazole and annulated thiazole derivatives bearing thiophene moiety in some cases. The structures of the new synthesized compounds were confirmed on the basis of their microanalytical and spectral properties. Some compounds were tested for their antimicrobial activity against six selected microorganisms using the standard antibacterial Gentamycin and antifungal Ketoconazole as references.</description><subject>Acetic acid</subject><subject>Acids</subject><subject>Antifungal agents</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Benzaldehyde</subject><subject>Carbonyls</subject><subject>Derivatives</subject><subject>Fungicides</subject><subject>fused thiazole</subject><subject>Gentamicin</subject><subject>indole</subject><subject>Isothiocyanate</subject><subject>Ketoconazole</subject><subject>Microorganisms</subject><subject>Molecular Structure</subject><subject>Piperonal</subject><subject>Sulfuric acid</subject><subject>thiazole</subject><subject>Thiazoles - chemical synthesis</subject><subject>Thiazoles - chemistry</subject><subject>Thioglycolic acid</subject><subject>thiophene-2-carbonyl isothiocyanate</subject><subject>Thiophenes - chemistry</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUU2P0zAUjBCILQtHrsgSl-XgxR-x0xyrLhSkFRx292w59gtxldjFThaVP8LfxWmXVuLynuQZz4zeFMVbSq4pK5cfza65NnSJCSmX7FmxoLyssGCMPy8WhJAaMy75RfEqpS0hTJCKvywuOGEVYaVYFH8eEiQUWsTw1X3nwq4DD5hho2MT_L6ftx7CmKF9P88P2sDoDFoZZ5FOSKNNCBbd7f3YBY_aENE6-DTGyYwuP2TpuzAA-ga_UDbQv0MPSHuLVt5PvR7Bnp9vILpHPbpHSK-LF63uE7x52pfFw-dP9-sv-Pb75ut6dYuNFPWImRHUUsKpKCva0qYWvKmEtaRkbW2ZYDbDxlja6sZKaPKNBMhaUiakyX_4ZXF11N3F8HOCNKrBJQN9rz2EKSlGqWAVlfVMff8fdRum6HM6lc9NlxWlZZ1Z-MgyMaQUoVW76AYd94oSNTemcmMqN6YOjWX-uyfVqRnAntj_KsqEzZGQUWd0H3zvPJy9TapMB4NTjBxEpcxGhFJF6prNY5mvk-PPSjdHpW0a9Q84WemYC-3hEEzKOWeep4RnuNNRged_AaAxwII</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>El-Mawgoud, Heba Kamal Abd</creator><creator>Atta-Allah, Saad Ramadan</creator><creator>Hemdan, Magdy Mohamed</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20181001</creationdate><title>Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives</title><author>El-Mawgoud, Heba Kamal Abd ; Atta-Allah, Saad Ramadan ; Hemdan, Magdy Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-2c51d10315471f1b953b75dd042f9d252d1d1ccd1fabd6eb4825e6961256c5473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acetic acid</topic><topic>Acids</topic><topic>Antifungal agents</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Benzaldehyde</topic><topic>Carbonyls</topic><topic>Derivatives</topic><topic>Fungicides</topic><topic>fused thiazole</topic><topic>Gentamicin</topic><topic>indole</topic><topic>Isothiocyanate</topic><topic>Ketoconazole</topic><topic>Microorganisms</topic><topic>Molecular Structure</topic><topic>Piperonal</topic><topic>Sulfuric acid</topic><topic>thiazole</topic><topic>Thiazoles - chemical synthesis</topic><topic>Thiazoles - chemistry</topic><topic>Thioglycolic acid</topic><topic>thiophene-2-carbonyl isothiocyanate</topic><topic>Thiophenes - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Mawgoud, Heba Kamal Abd</creatorcontrib><creatorcontrib>Atta-Allah, Saad Ramadan</creatorcontrib><creatorcontrib>Hemdan, Magdy Mohamed</creatorcontrib><creatorcontrib>Science and Education</creatorcontrib><creatorcontrib>aDepartment of Chemistry</creatorcontrib><creatorcontrib>bDepartment of Chemistry</creatorcontrib><creatorcontrib>Faculty of Science</creatorcontrib><creatorcontrib>Faculty of Women for Arts</creatorcontrib><creatorcontrib>Ain Shams University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Mawgoud, Heba Kamal Abd</au><au>Atta-Allah, Saad Ramadan</au><au>Hemdan, Magdy Mohamed</au><aucorp>Science and Education</aucorp><aucorp>aDepartment of Chemistry</aucorp><aucorp>bDepartment of Chemistry</aucorp><aucorp>Faculty of Science</aucorp><aucorp>Faculty of Women for Arts</aucorp><aucorp>Ain Shams University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>66</volume><issue>10</issue><spage>992</spage><epage>998</epage><pages>992-998</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>The reaction of thiophene-2-carbonyl isothiocyanate 2 with thioglycolic acid gave 2-(thiophene-2-carbonylcarbamothioylthio)acetic acid 3. Compound 3 was subjected to some selected reactions with sulphuric acid as well as benzaldehyde, piperonal and isatin under different reaction conditions. The products obtained were new derivatives of thiazole and annulated thiazole derivatives bearing thiophene moiety in some cases. The structures of the new synthesized compounds were confirmed on the basis of their microanalytical and spectral properties. Some compounds were tested for their antimicrobial activity against six selected microorganisms using the standard antibacterial Gentamycin and antifungal Ketoconazole as references.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>30270245</pmid><doi>10.1248/cpb.c18-00482</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Acetic acid Acids Antifungal agents Antimicrobial activity Antimicrobial agents Benzaldehyde Carbonyls Derivatives Fungicides fused thiazole Gentamicin indole Isothiocyanate Ketoconazole Microorganisms Molecular Structure Piperonal Sulfuric acid thiazole Thiazoles - chemical synthesis Thiazoles - chemistry Thioglycolic acid thiophene-2-carbonyl isothiocyanate Thiophenes - chemistry |
| title | Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives |
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