HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity

Synthesis, physicochemical and biological properties and preliminary anticancer activity of new star-shaped polymer–doxorubicin (DOX) conjugates targeted with anti-CD20 monoclonal antibody were investigated. Mild reduction of antibody (Ab) with dithiothreitol (DTT) resulted in introduction of thiol...

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Veröffentlicht in:	Journal of controlled release 2009-11, Vol.140 (1), p.18-26
Hauptverfasser:	Etrych, Tomáš, Strohalm, Jiří, Kovář, Lubomír, Kabešová, Martina, Říhová, Blanka, Ulbrich, Karel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - chemistry Animals Antibiotics, Antineoplastic - chemistry Antibodies, Monoclonal - immunology Antitumor activity Antitumor agents Biological and medical sciences Burkitt Lymphoma - drug therapy Burkitt Lymphoma - metabolism Cancer Cell Line, Tumor Cell membranes Controlled release Copolymers Cytostatic Agents - metabolism Dithiothreitol Doxorubicin Doxorubicin - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug delivery Drug Delivery Systems Drug development Drug Evaluation, Preclinical Drug targeting Flow cytometry General pharmacology HPMA copolymers Humans Hydrogen-Ion Concentration Hydrolysis Lymphoma, T-Cell - drug therapy Lymphoma, T-Cell - metabolism Lysosomal enzymes Male Medical sciences Methacrylates - chemistry Mice Models, Chemical Molecular Weight Monoclonal anti-CD20 antibody Monoclonal antibodies Oligopeptides pH effects Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers - chemistry Solubility Thiols Tumor cell lines Water - chemistry
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