Histamine H3 receptor agonists reduce L-dopa-induced chorea, but not dystonia, in the MPTP-lesioned nonhuman primate model of Parkinson's disease

L‐dopa–induced dyskinesia (LID) remains a major complication of the treatment of Parkinson's disease. The neural mechanisms underlying LID are thought to involve overactivity of striatal glutamatergic neurotransmission, with resultant underactivation of the output regions of the basal ganglia....

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Veröffentlicht in:	Movement disorders 2006-06, Vol.21 (6), p.839-846
Hauptverfasser:	Gomez-Ramirez, Jordi, Johnston, Tom H., Visanji, Naomi P., Fox, Susan H., Brotchie, Jonathan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Callithrix Chorea - chemically induced Chorea - prevention & control Disease Models, Animal Female Histamine Agonists - pharmacology histamine H3 receptor agonist L-dopa-induced dyskinesia Levodopa - adverse effects MPTP-lesioned marmoset Parkinson Disease - drug therapy Parkinson Disease - physiopathology Parkinson's disease Primates Receptors, Histamine H3 - physiology
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