Pain Behavior Measures to Quantitate Joint Pain and Response to Neurotoxin Treatment in Murine Models of Arthritis

ABSTRACT Objective. To evaluate the validity of newly developed pain behavior measures in two murine models of inflammatory arthritis and to determine the ability of these measures to evaluate the analgesic effectiveness of intra‐articular (IA) botulinum toxin type A (BoNT/A) for treatment of arthr...

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Veröffentlicht in:	Pain medicine (Malden, Mass.) Mass.), 2009-10, Vol.10 (7), p.1218-1228
Hauptverfasser:	Krug, Hollis E., Frizelle, Sandra, McGarraugh, Pari, Mahowald, Maren L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthralgia - diagnosis Arthralgia - drug therapy Arthralgia - etiology Arthritis Arthritis - complications Arthritis - diagnosis Arthritis - drug therapy Behavior, Animal - drug effects Botulinum Toxins, Type A - administration & dosage Disease Models, Animal Female Mice Mice, Inbred C57BL Neurotoxin Neurotoxins - administration & dosage Pain Pain Measurement - drug effects Reproducibility of Results Sensitivity and Specificity Treatment Outcome
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