Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor
Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a cal...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2018-10, Vol.29 (10), p.151-8, Article 151 |
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| creator | Sugiura, Yuki Munar, Melvin L. Ishikawa, Kunio |
| description | Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 ± 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 ± 4.5% and, 69.0 ± 1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes. |
| doi_str_mv | 10.1007/s10856-018-6162-1 |
| format | Article |
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In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 ± 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 ± 4.5% and, 69.0 ± 1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-018-6162-1</identifier><identifier>PMID: 30264167</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biomaterials ; Biomaterials Synthesis and Characterization ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Bone biomaterials ; Bone Regeneration ; Bone Substitutes - chemistry ; Calcium ; Calcium phosphates ; Calcium Phosphates - chemistry ; Calcium sulfate ; Calcium Sulfate - chemistry ; Calcium sulfate hemihydrate ; Ceramics ; Chemical precipitation ; Chemistry and Materials Science ; Collagen ; Collagen - chemistry ; Composites ; Dissolution ; Durapatite - chemistry ; Fabrication ; Feasibility Studies ; Gelatin ; Glass ; Hydroxyapatite ; Implantation ; Macroporosity ; Male ; Materials Science ; Microporosity ; Natural Materials ; Octacalcium phosphate ; Osteogenesis ; Polymer Sciences ; Powder ; Precursors ; Rabbits ; Regenerative Medicine/Tissue Engineering ; Saline solutions ; Solubility ; Substitute bone ; Surfaces and Interfaces ; Surgical implants ; Tensile Strength ; Thin Films</subject><ispartof>Journal of materials science. Materials in medicine, 2018-10, Vol.29 (10), p.151-8, Article 151</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Journal of Materials Science: Materials in Medicine is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-16049962a5cb611797d7529b6b85247bebc45e81f6cb953f5d864d86109069883</citedby><cites>FETCH-LOGICAL-c372t-16049962a5cb611797d7529b6b85247bebc45e81f6cb953f5d864d86109069883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-018-6162-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-018-6162-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30264167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugiura, Yuki</creatorcontrib><creatorcontrib>Munar, Melvin L.</creatorcontrib><creatorcontrib>Ishikawa, Kunio</creatorcontrib><title>Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 ± 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 ± 4.5% and, 69.0 ± 1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes.</description><subject>Animals</subject><subject>Biomaterials</subject><subject>Biomaterials Synthesis and Characterization</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Bone biomaterials</subject><subject>Bone Regeneration</subject><subject>Bone Substitutes - chemistry</subject><subject>Calcium</subject><subject>Calcium phosphates</subject><subject>Calcium Phosphates - chemistry</subject><subject>Calcium sulfate</subject><subject>Calcium Sulfate - chemistry</subject><subject>Calcium sulfate hemihydrate</subject><subject>Ceramics</subject><subject>Chemical precipitation</subject><subject>Chemistry and Materials Science</subject><subject>Collagen</subject><subject>Collagen - chemistry</subject><subject>Composites</subject><subject>Dissolution</subject><subject>Durapatite - chemistry</subject><subject>Fabrication</subject><subject>Feasibility Studies</subject><subject>Gelatin</subject><subject>Glass</subject><subject>Hydroxyapatite</subject><subject>Implantation</subject><subject>Macroporosity</subject><subject>Male</subject><subject>Materials Science</subject><subject>Microporosity</subject><subject>Natural Materials</subject><subject>Octacalcium phosphate</subject><subject>Osteogenesis</subject><subject>Polymer Sciences</subject><subject>Powder</subject><subject>Precursors</subject><subject>Rabbits</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Saline solutions</subject><subject>Solubility</subject><subject>Substitute bone</subject><subject>Surfaces and Interfaces</subject><subject>Surgical implants</subject><subject>Tensile Strength</subject><subject>Thin 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugiura, Yuki</au><au>Munar, Melvin L.</au><au>Ishikawa, Kunio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>29</volume><issue>10</issue><spage>151</spage><epage>8</epage><pages>151-8</pages><artnum>151</artnum><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 ± 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 ± 4.5% and, 69.0 ± 1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30264167</pmid><doi>10.1007/s10856-018-6162-1</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biomaterials Biomaterials Synthesis and Characterization Biomedical Engineering and Bioengineering Biomedical materials Bone biomaterials Bone Regeneration Bone Substitutes - chemistry Calcium Calcium phosphates Calcium Phosphates - chemistry Calcium sulfate Calcium Sulfate - chemistry Calcium sulfate hemihydrate Ceramics Chemical precipitation Chemistry and Materials Science Collagen Collagen - chemistry Composites Dissolution Durapatite - chemistry Fabrication Feasibility Studies Gelatin Glass Hydroxyapatite Implantation Macroporosity Male Materials Science Microporosity Natural Materials Octacalcium phosphate Osteogenesis Polymer Sciences Powder Precursors Rabbits Regenerative Medicine/Tissue Engineering Saline solutions Solubility Substitute bone Surfaces and Interfaces Surgical implants Tensile Strength Thin Films |
| title | Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor |
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