Signature of Aberrantly Expressed microRNAs in the Striatum of Rotenone-Induced Parkinsonian Rats

Parkinson’s disease (PD) is a highly complex brain disorder regarding clinical presentation, pathogenesis, and therapeutics. The cardinal motor signs, i.e., rigidity, bradykinesia, and unilateral tremors, arise in consequence of a progressive neuron death during the prodromal phase. Although multipl...

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Veröffentlicht in:	Neurochemical research 2018-11, Vol.43 (11), p.2132-2140
Hauptverfasser:	Horst, Camila Hillesheim, Schlemmer, Franciele, de Aguiar Montenegro, Natália, Domingues, Ana Carolina Martins, Ferreira, Gabriel Ginani, da Silva Ribeiro, Cínthia Yara, de Andrade, Rafael Rocha, Del Bel Guimarães, Elaine, Titze-de-Almeida, Simoneide Souza, Titze-de-Almeida, Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal ganglia Biochemistry Biomedical and Life Sciences Biomedicine Brain Cell Biology Cell death Central nervous system diseases Corpus Striatum - drug effects Corpus Striatum - metabolism Disease Models, Animal Dopamine receptors Dopaminergic Neurons - metabolism Male MicroRNAs MicroRNAs - drug effects MicroRNAs - metabolism miRNA Molecular modelling Motors Movement disorders Neostriatum Neostriatum - drug effects Neostriatum - metabolism Nervous system Neurochemistry Neurodegeneration Neurodegenerative diseases Neurology Neuroprotection Neuroprotective Agents - pharmacology Neurosciences Original Paper Parkinson Disease - metabolism Parkinson's disease Parkinsonian Disorders - metabolism Pathogenesis Patients Rats Rats, Wistar Rigidity Rodents Rotenone Rotenone - pharmacology Substantia Nigra - drug effects Substantia Nigra - metabolism Tremors
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