Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability
Background Focal nodular hyperplasia and hepatic adenoma are rare liver tumors in which specific features on contrast-enhanced ultrasound (US) have been reported but are little known in children. Objective To assess the interobserver agreement in diagnosing and differentiating focal nodular hyperpla...
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| Veröffentlicht in: | Pediatric radiology 2019-01, Vol.49 (1), p.82-90 |
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| creator | Fang, Cheng Bernardo, Silvia Sellars, Maria E. Deganello, Annamaria Sidhu, Paul S. |
| description | Background
Focal nodular hyperplasia and hepatic adenoma are rare liver tumors in which specific features on contrast-enhanced ultrasound (US) have been reported but are little known in children.
Objective
To assess the interobserver agreement in diagnosing and differentiating focal nodular hyperplasia and hepatic adenoma in children using established adult contrast-enhanced US characteristics.
Materials and methods
Thirty children with a definite or probable diagnosis of focal nodular hyperplasia or hepatic adenoma on magnetic resonance imaging (MRI)/histology who underwent contrast-enhanced US studies were included. Typical and additional contrast-enhanced US features of focal nodular hyperplasia and hepatic adenoma were included. The lesions were classified as definite/probable focal nodular hyperplasia, definite/probably hepatic adenoma or unclassified. The interobserver kappa of contrast-enhanced US characteristics was calculated.
Results
Focal nodular hyperplasia and hepatic adenoma in children demonstrate contrast-enhanced US characteristics similar to those in adults. Among the nine lesions with confirmed histological diagnosis, correct diagnosis was made in 7 (77.8%) based on contrast-enhanced US criteria. Two lesions were unclassified by both observers due to a mixed arterial filling pattern. Interobserver kappa for contrast-enhanced US diagnosis was 0.64 (
P |
| doi_str_mv | 10.1007/s00247-018-4250-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2114697981</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2114697981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-1c5060e7f15ebe97472c05823377c44dad02252b63ccf0b4e34a19c87549fd913</originalsourceid><addsrcrecordid>eNp1kU2L1TAUhoMoznX0B7iRgBs3dU6-msadXPyCgdnMrEuans7N0JvUJBXu2j9uyh0VBFchyfO-58BDyGsG7xmAvsoAXOoGWNdIrqBRT8iOScEbZkz3lOxAAGtASnNBXuT8AABCMfGcXAjgrWat2pGf-xhKsrk0GA42OBzpOm8PcQ0j9YGWA9LR2_sQs880TnTBei3JOzpFZ2ca4rjONtHDacG0zDZ7S23NHnCxpVJ2xBCP9kMtK5jikDH9wEQTzt4Ofvbl9JI8m-yc8dXjeUnuPn-63X9trm--fNt_vG6c0Lw0zCloAfXEFA5otNTcgeq4EFo7KUc7AueKD61wboJBopCWGddpJc00GiYuybtz75Li9xVz6Y8-O5xnGzCuueeMydZo023o23_Qh7imULfbKKGhbmQqxc6USzHnhFO_JH-06dQz6DdD_dlQXw31m6Fe1cybx-Z1OOL4J_FbSQX4Gcj1K9xj-jv6_62_AEsQnRY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2113703729</pqid></control><display><type>article</type><title>Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability</title><source>Springer Nature - Complete Springer Journals</source><creator>Fang, Cheng ; Bernardo, Silvia ; Sellars, Maria E. ; Deganello, Annamaria ; Sidhu, Paul S.</creator><creatorcontrib>Fang, Cheng ; Bernardo, Silvia ; Sellars, Maria E. ; Deganello, Annamaria ; Sidhu, Paul S.</creatorcontrib><description>Background
Focal nodular hyperplasia and hepatic adenoma are rare liver tumors in which specific features on contrast-enhanced ultrasound (US) have been reported but are little known in children.
Objective
To assess the interobserver agreement in diagnosing and differentiating focal nodular hyperplasia and hepatic adenoma in children using established adult contrast-enhanced US characteristics.
Materials and methods
Thirty children with a definite or probable diagnosis of focal nodular hyperplasia or hepatic adenoma on magnetic resonance imaging (MRI)/histology who underwent contrast-enhanced US studies were included. Typical and additional contrast-enhanced US features of focal nodular hyperplasia and hepatic adenoma were included. The lesions were classified as definite/probable focal nodular hyperplasia, definite/probably hepatic adenoma or unclassified. The interobserver kappa of contrast-enhanced US characteristics was calculated.
Results
Focal nodular hyperplasia and hepatic adenoma in children demonstrate contrast-enhanced US characteristics similar to those in adults. Among the nine lesions with confirmed histological diagnosis, correct diagnosis was made in 7 (77.8%) based on contrast-enhanced US criteria. Two lesions were unclassified by both observers due to a mixed arterial filling pattern. Interobserver kappa for contrast-enhanced US diagnosis was 0.64 (
P
<0.0001).
Conclusion
There is a good interobserver kappa for separating focal nodular hyperplasia from hepatic adenoma in children using established adult contrast-enhanced US features.</description><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-018-4250-5</identifier><identifier>PMID: 30267165</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenoma ; Adults ; Children ; Diagnosis ; Histology ; Hyperplasia ; Imaging ; Lesions ; Liver ; Liver cancer ; Magnetic resonance imaging ; Medical diagnosis ; Medical imaging ; Medicine ; Medicine & Public Health ; Neuroradiology ; NMR ; Nuclear magnetic resonance ; Nuclear Medicine ; Oncology ; Original Article ; Pediatrics ; Radiology ; Tumors ; Ultrasonic imaging ; Ultrasound</subject><ispartof>Pediatric radiology, 2019-01, Vol.49 (1), p.82-90</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Pediatric Radiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-1c5060e7f15ebe97472c05823377c44dad02252b63ccf0b4e34a19c87549fd913</citedby><cites>FETCH-LOGICAL-c372t-1c5060e7f15ebe97472c05823377c44dad02252b63ccf0b4e34a19c87549fd913</cites><orcidid>0000-0001-9649-8904</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00247-018-4250-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00247-018-4250-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30267165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Cheng</creatorcontrib><creatorcontrib>Bernardo, Silvia</creatorcontrib><creatorcontrib>Sellars, Maria E.</creatorcontrib><creatorcontrib>Deganello, Annamaria</creatorcontrib><creatorcontrib>Sidhu, Paul S.</creatorcontrib><title>Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><addtitle>Pediatr Radiol</addtitle><description>Background
Focal nodular hyperplasia and hepatic adenoma are rare liver tumors in which specific features on contrast-enhanced ultrasound (US) have been reported but are little known in children.
Objective
To assess the interobserver agreement in diagnosing and differentiating focal nodular hyperplasia and hepatic adenoma in children using established adult contrast-enhanced US characteristics.
Materials and methods
Thirty children with a definite or probable diagnosis of focal nodular hyperplasia or hepatic adenoma on magnetic resonance imaging (MRI)/histology who underwent contrast-enhanced US studies were included. Typical and additional contrast-enhanced US features of focal nodular hyperplasia and hepatic adenoma were included. The lesions were classified as definite/probable focal nodular hyperplasia, definite/probably hepatic adenoma or unclassified. The interobserver kappa of contrast-enhanced US characteristics was calculated.
Results
Focal nodular hyperplasia and hepatic adenoma in children demonstrate contrast-enhanced US characteristics similar to those in adults. Among the nine lesions with confirmed histological diagnosis, correct diagnosis was made in 7 (77.8%) based on contrast-enhanced US criteria. Two lesions were unclassified by both observers due to a mixed arterial filling pattern. Interobserver kappa for contrast-enhanced US diagnosis was 0.64 (
P
<0.0001).
Conclusion
There is a good interobserver kappa for separating focal nodular hyperplasia from hepatic adenoma in children using established adult contrast-enhanced US features.</description><subject>Adenoma</subject><subject>Adults</subject><subject>Children</subject><subject>Diagnosis</subject><subject>Histology</subject><subject>Hyperplasia</subject><subject>Imaging</subject><subject>Lesions</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Magnetic resonance imaging</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Radiology</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kU2L1TAUhoMoznX0B7iRgBs3dU6-msadXPyCgdnMrEuans7N0JvUJBXu2j9uyh0VBFchyfO-58BDyGsG7xmAvsoAXOoGWNdIrqBRT8iOScEbZkz3lOxAAGtASnNBXuT8AABCMfGcXAjgrWat2pGf-xhKsrk0GA42OBzpOm8PcQ0j9YGWA9LR2_sQs880TnTBei3JOzpFZ2ca4rjONtHDacG0zDZ7S23NHnCxpVJ2xBCP9kMtK5jikDH9wEQTzt4Ofvbl9JI8m-yc8dXjeUnuPn-63X9trm--fNt_vG6c0Lw0zCloAfXEFA5otNTcgeq4EFo7KUc7AueKD61wboJBopCWGddpJc00GiYuybtz75Li9xVz6Y8-O5xnGzCuueeMydZo023o23_Qh7imULfbKKGhbmQqxc6USzHnhFO_JH-06dQz6DdD_dlQXw31m6Fe1cybx-Z1OOL4J_FbSQX4Gcj1K9xj-jv6_62_AEsQnRY</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Fang, Cheng</creator><creator>Bernardo, Silvia</creator><creator>Sellars, Maria E.</creator><creator>Deganello, Annamaria</creator><creator>Sidhu, Paul S.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9649-8904</orcidid></search><sort><creationdate>20190101</creationdate><title>Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability</title><author>Fang, Cheng ; Bernardo, Silvia ; Sellars, Maria E. ; Deganello, Annamaria ; Sidhu, Paul S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-1c5060e7f15ebe97472c05823377c44dad02252b63ccf0b4e34a19c87549fd913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenoma</topic><topic>Adults</topic><topic>Children</topic><topic>Diagnosis</topic><topic>Histology</topic><topic>Hyperplasia</topic><topic>Imaging</topic><topic>Lesions</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Magnetic resonance imaging</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroradiology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Radiology</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Cheng</creatorcontrib><creatorcontrib>Bernardo, Silvia</creatorcontrib><creatorcontrib>Sellars, Maria E.</creatorcontrib><creatorcontrib>Deganello, Annamaria</creatorcontrib><creatorcontrib>Sidhu, Paul S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Cheng</au><au>Bernardo, Silvia</au><au>Sellars, Maria E.</au><au>Deganello, Annamaria</au><au>Sidhu, Paul S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability</atitle><jtitle>Pediatric radiology</jtitle><stitle>Pediatr Radiol</stitle><addtitle>Pediatr Radiol</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>49</volume><issue>1</issue><spage>82</spage><epage>90</epage><pages>82-90</pages><issn>0301-0449</issn><eissn>1432-1998</eissn><abstract>Background
Focal nodular hyperplasia and hepatic adenoma are rare liver tumors in which specific features on contrast-enhanced ultrasound (US) have been reported but are little known in children.
Objective
To assess the interobserver agreement in diagnosing and differentiating focal nodular hyperplasia and hepatic adenoma in children using established adult contrast-enhanced US characteristics.
Materials and methods
Thirty children with a definite or probable diagnosis of focal nodular hyperplasia or hepatic adenoma on magnetic resonance imaging (MRI)/histology who underwent contrast-enhanced US studies were included. Typical and additional contrast-enhanced US features of focal nodular hyperplasia and hepatic adenoma were included. The lesions were classified as definite/probable focal nodular hyperplasia, definite/probably hepatic adenoma or unclassified. The interobserver kappa of contrast-enhanced US characteristics was calculated.
Results
Focal nodular hyperplasia and hepatic adenoma in children demonstrate contrast-enhanced US characteristics similar to those in adults. Among the nine lesions with confirmed histological diagnosis, correct diagnosis was made in 7 (77.8%) based on contrast-enhanced US criteria. Two lesions were unclassified by both observers due to a mixed arterial filling pattern. Interobserver kappa for contrast-enhanced US diagnosis was 0.64 (
P
<0.0001).
Conclusion
There is a good interobserver kappa for separating focal nodular hyperplasia from hepatic adenoma in children using established adult contrast-enhanced US features.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30267165</pmid><doi>10.1007/s00247-018-4250-5</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9649-8904</orcidid></addata></record> |
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| ispartof | Pediatric radiology, 2019-01, Vol.49 (1), p.82-90 |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Adenoma Adults Children Diagnosis Histology Hyperplasia Imaging Lesions Liver Liver cancer Magnetic resonance imaging Medical diagnosis Medical imaging Medicine Medicine & Public Health Neuroradiology NMR Nuclear magnetic resonance Nuclear Medicine Oncology Original Article Pediatrics Radiology Tumors Ultrasonic imaging Ultrasound |
| title | Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability |
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