Effect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis
To determine the effect of paternal age on semen parameters and the live birth rate from in-vitro fertilisation (IVF) treatment. We performed a retrospective cohort study of couples undergoing a first IVF cycle between 2004 and 2014 in a tertiary assisted reproduction centre in Hong Kong. We analyse...
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| Veröffentlicht in: | Hong Kong medical journal = Xianggang yi xue za zhi 2018-10, Vol.24 (5), p.444-450 |
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| container_title | Hong Kong medical journal = Xianggang yi xue za zhi |
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| creator | Lai, S F Li, R Hw Yeung, W Sb Ng, E Hy |
| description | To determine the effect of paternal age on semen parameters and the live birth rate from in-vitro fertilisation (IVF) treatment.
We performed a retrospective cohort study of couples undergoing a first IVF cycle between 2004 and 2014 in a tertiary assisted reproduction centre in Hong Kong.
We analysed 3549 cases. Paternal age ≥40 years was negatively correlated with semen volume, progressive motility, total motility and total normal motile count (P |
| doi_str_mv | 10.12809/hkmj177111 |
| format | Article |
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We performed a retrospective cohort study of couples undergoing a first IVF cycle between 2004 and 2014 in a tertiary assisted reproduction centre in Hong Kong.
We analysed 3549 cases. Paternal age ≥40 years was negatively correlated with semen volume, progressive motility, total motility and total normal motile count (P<0.005) and positively correlated with sperm concentration (P<0.001). There was no correlation with sperm count, normal morphology, or total motile count. Subgroup analyses in Chinese men only and in men with normal versus abnormal semen parameters showed the same correlations. Paternal age was positively associated with maternal age (P<0.001) and miscarriage (P=0.006), and negatively associated with ongoing pregnancy and live birth (P<0.001). Logistic regression showed that maternal age, total number of oocytes retrieved, and number of embryos transferred were significant factors which independently predicted the likelihood of live birth from IVF (all P<0.001).
Paternal age was negatively correlated with some semen parameters, which showed a significant decline after age 40 years. However, paternal age is not predictive of the live birth from IVF treatment.</description><identifier>ISSN: 1024-2708</identifier><identifier>EISSN: 2226-8707</identifier><identifier>DOI: 10.12809/hkmj177111</identifier><identifier>PMID: 30262678</identifier><language>eng</language><publisher>China: Hong Kong Academy of Medicine</publisher><subject>Adult ; Age ; Birth rate ; Embryos ; Female ; Fertilization in Vitro ; Hong Kong ; Humans ; Live Birth ; Male ; Maternal Age ; Miscarriage ; Morphology ; Motility ; Ovaries ; Ovulation ; Paternal Age ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Semen - physiology ; Sperm ; Ultrasonic imaging</subject><ispartof>Hong Kong medical journal = Xianggang yi xue za zhi, 2018-10, Vol.24 (5), p.444-450</ispartof><rights>2018. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2691-1c5901de97afcd8eaf5b2f31994c5cdd9fe6b0cc85de8fdcd9458edef6b031d53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30262678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, S F</creatorcontrib><creatorcontrib>Li, R Hw</creatorcontrib><creatorcontrib>Yeung, W Sb</creatorcontrib><creatorcontrib>Ng, E Hy</creatorcontrib><creatorcontrib>Department of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam, Hong Kong</creatorcontrib><title>Effect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis</title><title>Hong Kong medical journal = Xianggang yi xue za zhi</title><addtitle>Hong Kong Med J</addtitle><description>To determine the effect of paternal age on semen parameters and the live birth rate from in-vitro fertilisation (IVF) treatment.
We performed a retrospective cohort study of couples undergoing a first IVF cycle between 2004 and 2014 in a tertiary assisted reproduction centre in Hong Kong.
We analysed 3549 cases. Paternal age ≥40 years was negatively correlated with semen volume, progressive motility, total motility and total normal motile count (P<0.005) and positively correlated with sperm concentration (P<0.001). There was no correlation with sperm count, normal morphology, or total motile count. Subgroup analyses in Chinese men only and in men with normal versus abnormal semen parameters showed the same correlations. Paternal age was positively associated with maternal age (P<0.001) and miscarriage (P=0.006), and negatively associated with ongoing pregnancy and live birth (P<0.001). Logistic regression showed that maternal age, total number of oocytes retrieved, and number of embryos transferred were significant factors which independently predicted the likelihood of live birth from IVF (all P<0.001).
Paternal age was negatively correlated with some semen parameters, which showed a significant decline after age 40 years. However, paternal age is not predictive of the live birth from IVF treatment.</description><subject>Adult</subject><subject>Age</subject><subject>Birth rate</subject><subject>Embryos</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Hong Kong</subject><subject>Humans</subject><subject>Live Birth</subject><subject>Male</subject><subject>Maternal Age</subject><subject>Miscarriage</subject><subject>Morphology</subject><subject>Motility</subject><subject>Ovaries</subject><subject>Ovulation</subject><subject>Paternal Age</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Retrospective Studies</subject><subject>Semen - physiology</subject><subject>Sperm</subject><subject>Ultrasonic imaging</subject><issn>1024-2708</issn><issn>2226-8707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkctLAzEQxoMotlZP3iXgRZDVJPtKvEmpDyh40fOSTSY2dR81yRYK_vGm1gd4Gpj5fd8k8yF0SskVZZyI68Vbu6RlSSndQ2PGWJHwkpT7aEwJyxJWEj5CR94vCWE8F-QQjVLCClaUfIw-ZsaACrg3eCUDuE42WL4C7jvsoYUudp1sIU48lp3GjV0Drq0LC-wiv9XZLlnb4HpswAXbWC-DjfLgQIboEG6wxA4i4Fdx01Yv45aNt_4YHRjZeDj5rhP0cjd7nj4k86f7x-ntPFGsEDShKr6aahClNEpzkCavmUmpEJnKldbCQFETpXiugRuttMhyDhpM7KZU5-kEXex8V65_H8CHqrVeQdPIDvrBV4zSrBBFmqcRPf-HLvthe5VIlTwejeRUROpyR6n4K-_AVCtnW-k2FSXVVyjVXyiRPvv2HOoW9C_7k0L6CRagioc</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Lai, S F</creator><creator>Li, R Hw</creator><creator>Yeung, W Sb</creator><creator>Ng, E Hy</creator><general>Hong Kong Academy of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20181001</creationdate><title>Effect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis</title><author>Lai, S F ; Li, R Hw ; Yeung, W Sb ; Ng, E Hy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2691-1c5901de97afcd8eaf5b2f31994c5cdd9fe6b0cc85de8fdcd9458edef6b031d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Age</topic><topic>Birth rate</topic><topic>Embryos</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Hong Kong</topic><topic>Humans</topic><topic>Live Birth</topic><topic>Male</topic><topic>Maternal Age</topic><topic>Miscarriage</topic><topic>Morphology</topic><topic>Motility</topic><topic>Ovaries</topic><topic>Ovulation</topic><topic>Paternal Age</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Retrospective Studies</topic><topic>Semen - physiology</topic><topic>Sperm</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, S F</creatorcontrib><creatorcontrib>Li, R Hw</creatorcontrib><creatorcontrib>Yeung, W Sb</creatorcontrib><creatorcontrib>Ng, E Hy</creatorcontrib><creatorcontrib>Department of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam, Hong Kong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Hong Kong medical journal = Xianggang yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, S F</au><au>Li, R Hw</au><au>Yeung, W Sb</au><au>Ng, E Hy</au><aucorp>Department of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam, Hong Kong</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis</atitle><jtitle>Hong Kong medical journal = Xianggang yi xue za zhi</jtitle><addtitle>Hong Kong Med J</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>24</volume><issue>5</issue><spage>444</spage><epage>450</epage><pages>444-450</pages><issn>1024-2708</issn><eissn>2226-8707</eissn><abstract>To determine the effect of paternal age on semen parameters and the live birth rate from in-vitro fertilisation (IVF) treatment.
We performed a retrospective cohort study of couples undergoing a first IVF cycle between 2004 and 2014 in a tertiary assisted reproduction centre in Hong Kong.
We analysed 3549 cases. Paternal age ≥40 years was negatively correlated with semen volume, progressive motility, total motility and total normal motile count (P<0.005) and positively correlated with sperm concentration (P<0.001). There was no correlation with sperm count, normal morphology, or total motile count. Subgroup analyses in Chinese men only and in men with normal versus abnormal semen parameters showed the same correlations. Paternal age was positively associated with maternal age (P<0.001) and miscarriage (P=0.006), and negatively associated with ongoing pregnancy and live birth (P<0.001). Logistic regression showed that maternal age, total number of oocytes retrieved, and number of embryos transferred were significant factors which independently predicted the likelihood of live birth from IVF (all P<0.001).
Paternal age was negatively correlated with some semen parameters, which showed a significant decline after age 40 years. However, paternal age is not predictive of the live birth from IVF treatment.</abstract><cop>China</cop><pub>Hong Kong Academy of Medicine</pub><pmid>30262678</pmid><doi>10.12809/hkmj177111</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Birth rate Embryos Female Fertilization in Vitro Hong Kong Humans Live Birth Male Maternal Age Miscarriage Morphology Motility Ovaries Ovulation Paternal Age Pregnancy Pregnancy Rate Retrospective Studies Semen - physiology Sperm Ultrasonic imaging |
| title | Effect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis |
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