Towards quantitative and multiplexed in vivo functional cancer genomics

Large-scale sequencing of human tumours has uncovered a vast array of genomic alterations. Genetically engineered mouse models recapitulate many features of human cancer and have been instrumental in assigning biological meaning to specific cancer-associated alterations. However, their time, cost an...

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Veröffentlicht in:	Nature reviews. Genetics 2018-12, Vol.19 (12), p.741-755
Hauptverfasser:	Winters, Ian P., Murray, Christopher W., Winslow, Monte M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1511 631/1647/334/1874/345 631/1647/767/70 631/208/2489/144/68 631/208/4041/3196 631/208/69 Agriculture Animal Genetics and Genomics Animal models Biomedical and Life Sciences Biomedicine Cancer Cancer genetics Cancer Research CRISPR Gene editing Gene Function Genes Genetic engineering Genetically modified organisms Genomes Genomics Human Genetics Review Article Tumors
Online-Zugang:	Volltext
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