microRNA-125b Regulates Apoptosis by Targeting Bone Morphogenetic Protein Receptor 1B in Yak Granulosa Cells

The intronic microRNA, miR-125b, plays a vital role in promyelocytic and hematopoietic stem cells, and in the development and apoptosis of cancer cells. In this study, we showed that miR-125b regulates granulosa cell (GC) apoptosis in the yak ovary. Bioinformatic analyses and luciferase reporter ass...

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Veröffentlicht in:	DNA and cell biology 2018-11, Vol.37 (11), p.878-887
Hauptverfasser:	Yao, Yilong, Niu, Jiaqiang, Sizhu, Suolang, Li, Bojiang, Chen, Yun, Li, Rongyang, Yangzong, Qiangba, Li, Qifa, Xu, Yefen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagomirs - genetics Antagomirs - metabolism Apoptosis Apoptosis - genetics Base Sequence Bax protein bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Binding Sites Bone Morphogenetic Protein Receptors, Type I - antagonists & inhibitors Bone Morphogenetic Protein Receptors, Type I - genetics Bone Morphogenetic Protein Receptors, Type I - metabolism Cancer Cattle Female Gene expression Gene Expression Regulation Granulosa cells Granulosa Cells - cytology Granulosa Cells - metabolism Hematopoietic stem cells MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism miRNA mRNA Primary Cell Culture Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Ribonucleic acid RNA RNA, Small Interfering - genetics RNA, Small Interfering - metabolism siRNA Stem cells
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