The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation

Cytopenia represents a significant complication after chemotherapy, irradiation before bone marrow (BM) transplantation or as a therapy for cancer. The mechanisms that determine the pace of BM recovery are not fully understood. During the recovery phase after chemotherapy or irradiation, the signals...

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Veröffentlicht in:	Leukemia 2009-08, Vol.23 (8), p.1378-1388
Hauptverfasser:	Abraham, M, Beider, K, Wald, H, Weiss, I D, Zipori, D, Galun, E, Nagler, A, Eizenberg, O, Peled, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone marrow Bone Marrow - drug effects Bone Marrow - radiation effects Bone marrow transplantation Cancer Cancer Research Care and treatment Cell Division - drug effects Cell proliferation Chemotherapy Coculture Techniques Colony-Forming Units Assay Critical Care Medicine CXCR4 protein Cyclophosphamide - pharmacology Cytopenia Drug Evaluation, Preclinical Female Graft Survival - drug effects Hematologic and hematopoietic diseases Hematology Hematopoiesis Hematopoietic Stem Cell Mobilization - methods Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Heterocyclic Compounds - pharmacology Heterocyclic Compounds - therapeutic use Integrin alpha4beta1 - biosynthesis Intensive Internal Medicine Irradiation Leukemia Leukocytes Matrix Metalloproteinase 9 - metabolism Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred C57BL Neutropenia - drug therapy Neutropenia - etiology Oncology original-article Peptides - pharmacology Peptides - therapeutic use Physiological aspects Progenitor cells Radiation Radiation Chimera Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - physiology Recovery Recovery (Medical) Recovery of Function - drug effects Specific Pathogen-Free Organisms Stem cells Stroma Stromal Cells - physiology Transplantation
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