Current prospects for mRNA gene delivery

Replication-deficient viruses have been used most successfully in the field of gene therapy because of their high transfection efficiency. However, the risk of insertional mutagenesis and induction of unwanted immune responses remains still critical for their safe application. On the other hand, non...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2009-03, Vol.71 (3), p.484-489
Hauptverfasser:	Yamamoto, Ayako, Kormann, Michael, Rosenecker, Joseph, Rudolph, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport DNA - administration & dosage DNA - immunology Gene delivery Gene therapy Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors Humans mRNA Plasmids - administration & dosage RNA, Messenger - administration & dosage RNA, Messenger - immunology
Online-Zugang:	Volltext
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