Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia
Background Alcohol abuse and dependence have important clinical implications for managing patients with schizophrenia. Alcoholism in schizophrenia patients can interfere with the course and prognosis of the schizophrenic illness. Objective The purpose of the present study was to compare the cognitiv...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2006-08, Vol.21 (8), p.711-718 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Mohamed, S. Bondi, M. W. Kasckow, J. W. Golshan, S. Jeste, D. V. |
| description | Background
Alcohol abuse and dependence have important clinical implications for managing patients with schizophrenia. Alcoholism in schizophrenia patients can interfere with the course and prognosis of the schizophrenic illness.
Objective
The purpose of the present study was to compare the cognitive status, symptom profile and quality of life of middle aged and older patients (>44 years old) with schizophrenia and alcohol abuse/dependence vs those without alcohol abuse/dependence. We initially hypothesized that more males in this age group with schizophrenia would exhibit alcoholism. We also examined the characteristics of the 45–54 year age group with those of the ≥ 55 year old group and hypothesized that comorbidity with alcohol would be associated with worse cognition and quality of life in later life.
Methods
Data were obtained from a database from the Center for Services and Interventions research at the University of California, San Diego. Patients had diagnoses of schizophrenia or schizoaffective disorder. Data collected included demographic characteristics, cognitive status (tested with the Mattis Dementia Rating Scale learning, the Figural and Story Memory Test of the Wechsler Memory Scale‐Revised and the California Verbal Learning Test [CVLT]). In addition, patients had undergone psychopathologic assessment and were screened for quality of life using the Quality of Well Being scale.
Results
We demonstrated that the older aged patients with alcoholism had worse scores assessing cognition relative to the same aged group without alcoholism. In addition, they had worse cognitive scores relative to the younger group (45–54 year old) with alcoholism. There was no significant difference with regards to quality of life. In addition, more males than females exhibited alcoholism.
Conclusion
The results are consistent with the premise that the higher cognitive function in the younger schizophrenia patients with alcoholism appear to mask the effects of alcohol use on cognition at that age. However, for the older group of schizophrenia patients, the effects of alcohol use on neuropsychological functioning appear to be deleterious. Copyright © 2006 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/gps.1528 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_21145332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1130518881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4458-cd2382a6ec1002624fd6ba113b17d1edd6df99c92d6f4680bf3c1c3f954598f73</originalsourceid><addsrcrecordid>eNp10d1rFDEQAPAgir1Wwb9AFkHxZWs-NtnsY6l6CvUUWhF8Cbl87KXmkm2y23r-9ea8xYLg0wTmx8xkBoBnCJ4iCPGbfsiniGL-ACwQ7LoaIcYeggXknNYME3gEjnO-hrDkEH8MjhDjDDPIFuBmZaYUVeyDG92tqewU1OhicKGvXKj0JL3fVdrJPsRsdLV1WntTyb68ZdCV8dqkIgY5OhPGXN25cVNJr-Imepe3f1BWG_crDptkgpNPwCMrfTZP53gCvr5_d3X-ob74vPx4fnZRq6ahvFYaE44lM2r_Q4Ybq9laIkTWqNXIaM207TrVYc1swzhcW6KQIrajDe24bckJeHWoO6R4M5k8iq3Lyngvg4lTFhihhhKCC3zxD7yOUwplNoExpGWVTVfQ6wNSKeacjBVDcluZdgJBsZ9QlBuI_Q0KfT7Xm9Zbo-_hvPQCXs5AZiW9TTIol-8dh6TFHS2uPrg7583uvw3F8svl3Hj2Lo_m518v0w_BWtJS8W21FFfwE6eXq7fiO_kNRfmtwQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220516649</pqid></control><display><type>article</type><title>Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Mohamed, S. ; Bondi, M. W. ; Kasckow, J. W. ; Golshan, S. ; Jeste, D. V.</creator><creatorcontrib>Mohamed, S. ; Bondi, M. W. ; Kasckow, J. W. ; Golshan, S. ; Jeste, D. V.</creatorcontrib><description>Background
Alcohol abuse and dependence have important clinical implications for managing patients with schizophrenia. Alcoholism in schizophrenia patients can interfere with the course and prognosis of the schizophrenic illness.
Objective
The purpose of the present study was to compare the cognitive status, symptom profile and quality of life of middle aged and older patients (>44 years old) with schizophrenia and alcohol abuse/dependence vs those without alcohol abuse/dependence. We initially hypothesized that more males in this age group with schizophrenia would exhibit alcoholism. We also examined the characteristics of the 45–54 year age group with those of the ≥ 55 year old group and hypothesized that comorbidity with alcohol would be associated with worse cognition and quality of life in later life.
Methods
Data were obtained from a database from the Center for Services and Interventions research at the University of California, San Diego. Patients had diagnoses of schizophrenia or schizoaffective disorder. Data collected included demographic characteristics, cognitive status (tested with the Mattis Dementia Rating Scale learning, the Figural and Story Memory Test of the Wechsler Memory Scale‐Revised and the California Verbal Learning Test [CVLT]). In addition, patients had undergone psychopathologic assessment and were screened for quality of life using the Quality of Well Being scale.
Results
We demonstrated that the older aged patients with alcoholism had worse scores assessing cognition relative to the same aged group without alcoholism. In addition, they had worse cognitive scores relative to the younger group (45–54 year old) with alcoholism. There was no significant difference with regards to quality of life. In addition, more males than females exhibited alcoholism.
Conclusion
The results are consistent with the premise that the higher cognitive function in the younger schizophrenia patients with alcoholism appear to mask the effects of alcohol use on cognition at that age. However, for the older group of schizophrenia patients, the effects of alcohol use on neuropsychological functioning appear to be deleterious. Copyright © 2006 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.1528</identifier><identifier>PMID: 16862606</identifier><identifier>CODEN: IJGPES</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Alcoholism ; Alcoholism - complications ; Alcoholism - physiopathology ; Alcoholism and acute alcohol poisoning ; Biological and medical sciences ; California ; Cognition ; Cognition & reasoning ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Cross-Sectional Studies ; dependence ; Diagnosis, Dual (Psychiatry) ; Female ; Fundamental and applied biological sciences. Psychology ; Geriatric psychiatry ; Geriatrics ; Humans ; late life ; Male ; Medical sciences ; Middle age ; Middle Aged ; Neuropsychological Tests ; Older people ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Quality of Life ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - physiopathology ; Toxicology</subject><ispartof>International journal of geriatric psychiatry, 2006-08, Vol.21 (8), p.711-718</ispartof><rights>Copyright © 2006 John Wiley & Sons, Ltd.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright John Wiley and Sons, Limited Aug 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4458-cd2382a6ec1002624fd6ba113b17d1edd6df99c92d6f4680bf3c1c3f954598f73</citedby><cites>FETCH-LOGICAL-c4458-cd2382a6ec1002624fd6ba113b17d1edd6df99c92d6f4680bf3c1c3f954598f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.1528$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.1528$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18037295$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16862606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed, S.</creatorcontrib><creatorcontrib>Bondi, M. W.</creatorcontrib><creatorcontrib>Kasckow, J. W.</creatorcontrib><creatorcontrib>Golshan, S.</creatorcontrib><creatorcontrib>Jeste, D. V.</creatorcontrib><title>Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Background
Alcohol abuse and dependence have important clinical implications for managing patients with schizophrenia. Alcoholism in schizophrenia patients can interfere with the course and prognosis of the schizophrenic illness.
Objective
The purpose of the present study was to compare the cognitive status, symptom profile and quality of life of middle aged and older patients (>44 years old) with schizophrenia and alcohol abuse/dependence vs those without alcohol abuse/dependence. We initially hypothesized that more males in this age group with schizophrenia would exhibit alcoholism. We also examined the characteristics of the 45–54 year age group with those of the ≥ 55 year old group and hypothesized that comorbidity with alcohol would be associated with worse cognition and quality of life in later life.
Methods
Data were obtained from a database from the Center for Services and Interventions research at the University of California, San Diego. Patients had diagnoses of schizophrenia or schizoaffective disorder. Data collected included demographic characteristics, cognitive status (tested with the Mattis Dementia Rating Scale learning, the Figural and Story Memory Test of the Wechsler Memory Scale‐Revised and the California Verbal Learning Test [CVLT]). In addition, patients had undergone psychopathologic assessment and were screened for quality of life using the Quality of Well Being scale.
Results
We demonstrated that the older aged patients with alcoholism had worse scores assessing cognition relative to the same aged group without alcoholism. In addition, they had worse cognitive scores relative to the younger group (45–54 year old) with alcoholism. There was no significant difference with regards to quality of life. In addition, more males than females exhibited alcoholism.
Conclusion
The results are consistent with the premise that the higher cognitive function in the younger schizophrenia patients with alcoholism appear to mask the effects of alcohol use on cognition at that age. However, for the older group of schizophrenia patients, the effects of alcohol use on neuropsychological functioning appear to be deleterious. Copyright © 2006 John Wiley & Sons, Ltd.</description><subject>Alcoholism</subject><subject>Alcoholism - complications</subject><subject>Alcoholism - physiopathology</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Biological and medical sciences</subject><subject>California</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Cross-Sectional Studies</subject><subject>dependence</subject><subject>Diagnosis, Dual (Psychiatry)</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geriatric psychiatry</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>late life</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Quality of Life</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - physiopathology</subject><subject>Toxicology</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10d1rFDEQAPAgir1Wwb9AFkHxZWs-NtnsY6l6CvUUWhF8Cbl87KXmkm2y23r-9ea8xYLg0wTmx8xkBoBnCJ4iCPGbfsiniGL-ACwQ7LoaIcYeggXknNYME3gEjnO-hrDkEH8MjhDjDDPIFuBmZaYUVeyDG92tqewU1OhicKGvXKj0JL3fVdrJPsRsdLV1WntTyb68ZdCV8dqkIgY5OhPGXN25cVNJr-Imepe3f1BWG_crDptkgpNPwCMrfTZP53gCvr5_d3X-ob74vPx4fnZRq6ahvFYaE44lM2r_Q4Ybq9laIkTWqNXIaM207TrVYc1swzhcW6KQIrajDe24bckJeHWoO6R4M5k8iq3Lyngvg4lTFhihhhKCC3zxD7yOUwplNoExpGWVTVfQ6wNSKeacjBVDcluZdgJBsZ9QlBuI_Q0KfT7Xm9Zbo-_hvPQCXs5AZiW9TTIol-8dh6TFHS2uPrg7583uvw3F8svl3Hj2Lo_m518v0w_BWtJS8W21FFfwE6eXq7fiO_kNRfmtwQ</recordid><startdate>200608</startdate><enddate>200608</enddate><creator>Mohamed, S.</creator><creator>Bondi, M. W.</creator><creator>Kasckow, J. W.</creator><creator>Golshan, S.</creator><creator>Jeste, D. V.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope></search><sort><creationdate>200608</creationdate><title>Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia</title><author>Mohamed, S. ; Bondi, M. W. ; Kasckow, J. W. ; Golshan, S. ; Jeste, D. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4458-cd2382a6ec1002624fd6ba113b17d1edd6df99c92d6f4680bf3c1c3f954598f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alcoholism</topic><topic>Alcoholism - complications</topic><topic>Alcoholism - physiopathology</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Biological and medical sciences</topic><topic>California</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Cross-Sectional Studies</topic><topic>dependence</topic><topic>Diagnosis, Dual (Psychiatry)</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Geriatric psychiatry</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>late life</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle age</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Older people</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Quality of Life</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - physiopathology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed, S.</creatorcontrib><creatorcontrib>Bondi, M. W.</creatorcontrib><creatorcontrib>Kasckow, J. W.</creatorcontrib><creatorcontrib>Golshan, S.</creatorcontrib><creatorcontrib>Jeste, D. V.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed, S.</au><au>Bondi, M. W.</au><au>Kasckow, J. W.</au><au>Golshan, S.</au><au>Jeste, D. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int. J. Geriat. Psychiatry</addtitle><date>2006-08</date><risdate>2006</risdate><volume>21</volume><issue>8</issue><spage>711</spage><epage>718</epage><pages>711-718</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><coden>IJGPES</coden><abstract>Background
Alcohol abuse and dependence have important clinical implications for managing patients with schizophrenia. Alcoholism in schizophrenia patients can interfere with the course and prognosis of the schizophrenic illness.
Objective
The purpose of the present study was to compare the cognitive status, symptom profile and quality of life of middle aged and older patients (>44 years old) with schizophrenia and alcohol abuse/dependence vs those without alcohol abuse/dependence. We initially hypothesized that more males in this age group with schizophrenia would exhibit alcoholism. We also examined the characteristics of the 45–54 year age group with those of the ≥ 55 year old group and hypothesized that comorbidity with alcohol would be associated with worse cognition and quality of life in later life.
Methods
Data were obtained from a database from the Center for Services and Interventions research at the University of California, San Diego. Patients had diagnoses of schizophrenia or schizoaffective disorder. Data collected included demographic characteristics, cognitive status (tested with the Mattis Dementia Rating Scale learning, the Figural and Story Memory Test of the Wechsler Memory Scale‐Revised and the California Verbal Learning Test [CVLT]). In addition, patients had undergone psychopathologic assessment and were screened for quality of life using the Quality of Well Being scale.
Results
We demonstrated that the older aged patients with alcoholism had worse scores assessing cognition relative to the same aged group without alcoholism. In addition, they had worse cognitive scores relative to the younger group (45–54 year old) with alcoholism. There was no significant difference with regards to quality of life. In addition, more males than females exhibited alcoholism.
Conclusion
The results are consistent with the premise that the higher cognitive function in the younger schizophrenia patients with alcoholism appear to mask the effects of alcohol use on cognition at that age. However, for the older group of schizophrenia patients, the effects of alcohol use on neuropsychological functioning appear to be deleterious. Copyright © 2006 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16862606</pmid><doi>10.1002/gps.1528</doi><tpages>8</tpages></addata></record> |
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| subjects | Alcoholism Alcoholism - complications Alcoholism - physiopathology Alcoholism and acute alcohol poisoning Biological and medical sciences California Cognition Cognition & reasoning Cognition Disorders - diagnosis Cognition Disorders - etiology Cross-Sectional Studies dependence Diagnosis, Dual (Psychiatry) Female Fundamental and applied biological sciences. Psychology Geriatric psychiatry Geriatrics Humans late life Male Medical sciences Middle age Middle Aged Neuropsychological Tests Older people Psychoanalysis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Quality of Life Schizophrenia Schizophrenia - complications Schizophrenia - physiopathology Toxicology |
| title | Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia |
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