High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence

Humanin is a novel, 24‐mer residue bioactive peptide, which antagonizes Alzheimer's disease (AD) related neurotoxicity and offers a hope for developing new therapeutics against AD. Access to adequate amounts of pure humanin is a prerequisite for further, thorough, investigation of the pharmacol...

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Veröffentlicht in:	Journal of peptide science 2004-10, Vol.10 (10), p.631-635
Hauptverfasser:	Evangelou, Alexandra, Zikos, Christos, Livaniou, Evangelia, Evangelatos, Gregory P.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Cl-tritylamidomethyl polystyrene resin Alzheimer Disease - drug therapy Alzheimer's disease Combinatorial Chemistry Techniques difficult sequence Fmoc-deprotection humanin Humans Intracellular Signaling Peptides and Proteins Neuroprotective Agents - chemical synthesis Peptides - chemical synthesis Proteins - chemical synthesis solid-phase peptide synthesis
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