Inhibitors of cyclic nucleotide phosphodiesterase PDE3 as adjunct therapy for dilated cardiomyopathy

PDE3 cyclic nucleotide phosphodiesterases are important in cyclic AMP (cAMP) and possibly cyclic GMP-mediated signalling in cardiac and vascular smooth muscle myocytes. Drugs that inhibit these enzymes have inotropic and vasodilatory actions that have proven useful in the short-term treatment of con...

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Veröffentlicht in:	Expert opinion on investigational drugs 2002-11, Vol.11 (11), p.1529-1536
Hauptverfasser:	Movsesian, Matthew A, Alharethi, Rami
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-AMP Phosphodiesterases - metabolism Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Animals cardiomyopathy Cardiomyopathy, Dilated - drug therapy Cardiomyopathy, Dilated - enzymology cyclic AMP cyclic GMP cyclic nucleotide phosphodiesterases Cyclic Nucleotide Phosphodiesterases, Type 3 dilated heart failure Humans inotropy myocardium Phosphodiesterase Inhibitors - pharmacology Phosphodiesterase Inhibitors - therapeutic use Receptors, Adrenergic, beta - metabolism Signal Transduction - drug effects Signal Transduction - physiology
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