Inference for a RPW-Type Clinical Trial with Repeated Monitoring for the Treatment of Rheumatoid Arthritis
The present paper describes a controlled clinical trial to investigate the effect of Pulsed Electro‐Magnetic Field for the treatment of sequentially entering patients with Rheumatoid Arthritis. According to the study design, repeated monitorings of the patients are carried out to assess their clinic...
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Veröffentlicht in: | Biometrical journal 2004-12, Vol.46 (6), p.769-779 |
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description | The present paper describes a controlled clinical trial to investigate the effect of Pulsed Electro‐Magnetic Field for the treatment of sequentially entering patients with Rheumatoid Arthritis. According to the study design, repeated monitorings of the patients are carried out to assess their clinical status. The allocation of the entering patients to either a therapy group or a placebo group is done using a newly designed adaptive allocation rule termed as randomized longitudinal play‐the‐winner rule. A discussion of some inference procedures is followed by the analysis of a real data, which shows a clear preference of the therapy over the placebo. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) |
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subjects | Adaptive design Applications Biology, psychology, social sciences Exact sciences and technology Experimental design Longitudinal observations Mathematics Medical sciences Probability and statistics Pulsed electro-magnetic field Randomized play-the-winner rule Sciences and techniques of general use Statistics Urn models |
title | Inference for a RPW-Type Clinical Trial with Repeated Monitoring for the Treatment of Rheumatoid Arthritis |
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